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Pitfalls in patient self-management of subcutaneous drug application : removal of rubber protection caps from ready-to-use syringes

Mengiardi, Seraina and Goepfert, Beat and Tsakiris, Dimitrios A. and Hersberger, Kurt E.. (2009) Pitfalls in patient self-management of subcutaneous drug application : removal of rubber protection caps from ready-to-use syringes. European journal of clinical pharmacology, Vol. 65, H. 10. S. 1061-1062.

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Official URL: http://edoc.unibas.ch/dok/A5253535

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Abstract

Outpatient subcutaneous therapies are becoming more and more common, such as the use of low-molecular-weight heparins (LMWH) for prophylaxis or for the therapeutic treatment of thromboembolisms, multiple sclerosis, arthritis, anemia, or female infertility. Based on reports from patients and nurses indicating that some ready-to-use syringes require a concerted effort to remove the rubber protection cap, we decided to evaluate cap removal forces of commercial LMWH pre-loaded syringes as we were unable to find an ISO-norm from such syringes nor studies on this topic. In conclusion, the mechanical cap-pull-off tests confirmed the results from self- and observer’s assessments, and importantdifferences between brands were observed. The pulloff forces correspond roughly to the force needed to hold a narrow-neck plastic flask containing 1–3 l of water by pinching the neck between a finger and thumb.Medical staff should be aware of these possibly crucial handling difficulties and their consequences for successful therapy and compliance.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Hämostaselabor (Marbet)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Hämostaselabor (Marbet)
05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Care (Hersberger)
UniBasel Contributors:Hersberger, Kurt E. and Tsakiris, Dimitrios A. and Göpfert, Beat and Mengiardi Nemec, Seraina
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0031-6970
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Sep 2014 08:02
Deposited On:22 Mar 2012 13:16

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