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Opposing roles for protein tyrosine phosphatases SHP2 and PTPN12 in breast cancer

Aceto, Nicola. Opposing roles for protein tyrosine phosphatases SHP2 and PTPN12 in breast cancer. 2011, PhD Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_9510

Abstract

Breast cancer is the most common malignancy among women. It is a very heterogeneous disease that progresses to metastasis, a usually fatal event. The cellular and biochemical mechanisms orchestrating this progression remain largely elusive. Therefore, the elucidation of the oncogenic and tumor-suppressive networks of cancer cells is fundamental to the development of targeted therapies for this presently incurable disease. We demonstrate a fundamental role for protein-tyrosine phosphatases SHP2 and PTPN12 in breast cancer. These results should lead to important therapeutic advances for the treatment of this disease.
Advisors:Bentires-Alj, Mohamed
Committee Members:Hynes, Nancy and Christofori, Gerhard M.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Spiess)
Item Type:Thesis
Thesis no:9510
Bibsysno:Link to catalogue
Number of Pages:146 S.
Language:English
Identification Number:
Last Modified:30 Jun 2016 10:42
Deposited On:20 Jul 2011 13:07

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