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Items where Division is "05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molekulare Pharmazie (Ricklin)"

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Number of items at this level: 69.

2021

Bechtler, Clément and Lamers, Christina. (2021) Macrocyclization strategies for cyclic peptides and peptidomimetics. RSC Medicinal Chemistry, 12 (8). pp. 1325-1351.

Wahl, Joel. Quantifying the Role of Water in Ligand-Protein Binding Processes. 2021, Doctoral Thesis, University of Basel, Faculty of Science.

14 December 2020

Hevey, Rachel. (2020) Sugar-coating the search for new therapeutics.

2020

Baas, Inge and Delvasto-Nuñez, Laura and Ligthart, Peter and Brouwer, Conny and Folman, Claudia and Reis, Edimara S. and Ricklin, Daniel and Lambris, John D. and Wouters, Diana and de Haas, Masja and Jongerius, Ilse and Zeerleder, Sacha S.. (2020) Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells. Haematologica, 105 (2). e57-e60.

Cramer, Jonathan and Jiang, Xiaohua and Schönemann, Wojciech and Silbermann, Marleen and Zihlmann, Pascal and Siegrist, Stefan and Fiege, Brigitte and Jakob, Roman Peter and Rabbani, Said and Maier, Timm and Ernst, Beat. (2020) Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding. RSC Chemical Biology, 1 (4). pp. 281-287.

Don, Charleen Gerogette. Pharmacogenetic modeling of human cytochrome P450 2D6; On the force of variation in inducing toxicity. 2020, Doctoral Thesis, University of Basel, Faculty of Science.

Hevey, Rachel. (2020) The role of fluorine in glycomimetic drug design. Chemistry - A European Journal, 27 (7). pp. 2240-2253.

Hughes, Sarah and Gumas, Justin and Lee, Rebecca and Rumano, Merita and Berger, Nadja and Gautam, Avneesh Kumar and Sfyroera, Georgia and Chan, Anna Lorena and Gnanaguru, Gopalan and Connor, Kip M. and Kim, Benjamin J. and Dunaief, Joshua L. and Ricklin, Daniel and Hajishengallis, George and Yancopoulou, Despina and Reis, Edimara S. and Mastellos, Dimitrios C. and Lambris, John D.. (2020) Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates. Clinical Immunology, 214. p. 108391.

Olcina, Monica M. and Kim, Ryan K. and Balanis, Nikolas G. and Li, Caiyun Grace and von Eyben, Rie and Graeber, Thomas G. and Ricklin, Daniel and Stucki, Manuel and Giaccia, Amato J.. (2020) Intracellular C4BPA Levels Regulate NF-κB-Dependent Apoptosis. iScience, 23 (10). p. 101594.

12 January 2019

Epper, Bettina. (12 January 2019) Dossier "Wirkstoffe" - Vom Molekül zum Medikament. Drogistenstern, (12/19-1/20). pp. 6-16.

2019

Hevey, Rachel. (2019) Bioisosteres of Carbohydrate Functional Groups in Glycomimetic Design. Biomimetics, 4 (3). p. 53.

Hevey, Rachel. (2019) Strategies for the Development of Glycomimetic Drug Candidates. Pharmaceuticals, 12 (2). p. 55.

Lombardi, Elisabetta and Matte, Alessandro and Risitano, Antonio M. and Ricklin, Daniel and Lambris, John D. and De Zanet, Denise and Jokiranta, Sakari T. and Martinelli, Nicola and Scambi, Cinzia and Salvagno, Gianluca and Bisoffi, Zeno and Colato, Chiara and Siciliano, Angela and Bortolami, Oscar and Mazzuccato, Mario and Zorzi, Francesco and De Marco, Luigi and De Franceschi, Lucia. (2019) Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule. Haematologica, 104 (5). pp. 919-928.

Mastellos, Dimitrios C. and Blom, Anna M. and Connolly, E. Sander and Daha, Mohamed R. and Geisbrecht, Brian V. and Ghebrehiwet, Berhane and Gros, Piet and Hajishengallis, George and Holers, V. Michael and Huber-Lang, Markus and Kinoshita, Taroh and Mollnes, Tom E. and Montgomery, Robert A. and Morgan, B. Paul and Nilsson, Bo and Pio, Ruben and Ricklin, Daniel and Risitano, Antonio M. and Taylor, Ronald P. and Mantovani, Alberto and Ioannidis, John P. A. and Lambris, John D.. (2019) 'Stealth' corporate innovation: an emerging threat for therapeutic drug development. Nature immunology, 20 (11). pp. 1409-1413.

Mastellos, Dimitrios C. and Ricklin, Daniel and Lambris, John D.. (2019) Clinical promise of next-generation complement therapeutics. Nature reviews. Drug discovery, 18 (9). pp. 707-729.

Pouw, Richard B. and Brouwer, Mieke C. and de Gast, Marlon and van Beek, Anna E. and van den Heuvel, Lambertus P. and Schmidt, Christoph Q. and van der Ende, Arie and Sánchez-Corral, Pilar and Kuijpers, Taco W. and Wouters, Diana. (2019) Potentiation of complement regulator factor H protects human endothelial cells from complement attack in aHUS sera. Blood advances, 3 (4). pp. 621-632.

van Griensven, Martijn and Ricklin, Daniel and Denk, Stephanie and Halbgebauer, Rebecca and Braun, Christian K. and Schultze, Anke and Hönes, Felix and Koutsogiannaki, Sofia and Primikyri, Alexandra and Reis, Edimara and Messerer, David and Hafner, Sebastian and Radermacher, Peter and Biglarnia, Ali-Reza and Resuello, Ranillo R. G. and Tuplano, Joel V. and Mayer, Benjamin and Nilsson, Kristina and Nilsson, Bo and Lambris, John D. and Huber-Lang, Markus. (2019) Protective Effects of the Complement Inhibitor Compstatin CP40 in Hemorrhagic Shock. Shock, 51 (1). pp. 78-87.

2018

Devaurs, Didier and Papanastasiou, Malvina and Antunes, Dinler A. and Abella, Jayvee R. and Moll, Mark and Ricklin, Daniel and Lambris, John D. and Kavraki, Lydia E.. (2018) Native State of Complement Protein C3d Analysed via Hydrogen Exchange and Conformational Sampling. International journal of computational biology and drug design, 11 (1-2). pp. 90-113.

Harris, Claire L. and Pouw, Richard B. and Kavanagh, David and Sun, Ruyue and Ricklin, Daniel. (2018) Developments in anti-complement therapy; from disease to clinical trial. Molecular immunology, 102. pp. 89-119.

Pouw, Richard B. and Brouwer, Mieke C. and van Beek, Anna E. and Józsi, Mihály and Wouters, Diana and Kuijpers, Taco W.. (2018) Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4. Frontiers in Immunology, 9. p. 729.

Pouw, Richard B. and Gómez Delgado, Irene and López Lera, Alberto and Rodríguez de Córdoba, Santiago and Wouters, Diana and Kuijpers, Taco W. and Sánchez-Corral, Pilar. (2018) High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3*B. Frontiers in Immunology, 9. p. 848.

Reis, Edimara S. and Mastellos, Dimitrios C. and Ricklin, Daniel and Mantovani, Alberto and Lambris, John D.. (2018) Complement in cancer: untangling an intricate relationship. Nature reviews. Immunology, 18 (1). pp. 5-18.

Ricklin, Daniel and Mastellos, Dimitrios C. and Reis, Edimara S. and Lambris, John D.. (2018) The renaissance of complement therapeutics. Nature Reviews Nephrology , 14 (1). pp. 26-47.

Sánchez-Corral, Pilar and Pouw, Richard B. and López-Trascasa, Margarita and Józsi, Mihály. (2018) Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family. Frontiers in immunology, 9. p. 1607.

Yuan, Xiaopeng and Yang, Mingjuan and Chen, Xiang and Zhang, Xuhua and Sukhadia, Shrey and Musolino, Najia and Bao, Huijing and Chen, Tingtao and Xu, Chen and Wang, Qirui and Santoro, Stephen and Ricklin, Daniel and Hu, Jia and Lin, Ruihe and Yang, Wei and Li, Zhijun and Qin, Weijun and Zhao, Aizhi and Scholler, Nathalie and Coukos, George. (2018) Correction to: Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy. Cancer immunology, immunotherapy : CII, 67 (2). pp. 329-339.

2017

Blatt, Adam Z. and Saggu, Gurpanna and Cortes, Claudio and Herbert, Andrew P. and Kavanagh, David and Ricklin, Daniel and Lambris, John D. and Ferreira, Viviana P.. (2017) Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation. Frontiers in Immunology, 8. p. 1586.

Devaurs, Didier and Antunes, Dinler A. and Papanastasiou, Malvina and Moll, Mark and Ricklin, Daniel and Lambris, John D. and Kavraki, Lydia E.. (2017) Coarse-Grained Conformational Sampling of Protein Structure Improves the Fit to Experimental Hydrogen-Exchange Data. Frontiers in Molecular Biosciences, 4. p. 13.

Flesch, Daniel and Cheung, Sun-Yee and Schmidt, Jurema and Gabler, Matthias and Heitel, Pascal and Kramer, Jan and Kaiser, Astrid and Hartmann, Markus and Lindner, Mara and Lüddens-Dämgen, Kerstin and Heering, Jan and Lamers, Christina and Lüddens, Hartmut and Wurglics, Mario and Proschak, Ewgenij and Schubert-Zsilavecz, Manfred and Merk, Daniel. (2017) Nonacidic Farnesoid X Receptor Modulators. Journal of Medicinal Chemistry, 60 (16). pp. 7199-7205.

Hajishengallis, George and Reis, Edimara S. and Mastellos, Dimitrios C. and Ricklin, Daniel and Lambris, John D.. (2017) Novel mechanisms and functions of complement. Nature Immunology, 18 (12). pp. 1288-1298.

Harder, Markus J. and Kuhn, Nadine and Schrezenmeier, Hubert and Höchsmann, Britta and von Zabern, Inge and Weinstock, Christof and Simmet, Thomas and Ricklin, Daniel and Lambris, John D. and Skerra, Arne and Anliker, Markus and Schmidt, Christoph Q.. (2017) Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation. Blood, 129 (8). pp. 970-980.

Hevey, Rachel and Ling, Chang-Chun. (2017) Studies on the 6-homologation of β-D-idopyranosides. Carbohydrate Research, 445. pp. 65-74.

Mastellos, Dimitrios C. and Reis, Edimara S. and Ricklin, Daniel and Smith, Richard J. and Lambris, John D.. (2017) Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery. Trends in Immunology, 38 (6). pp. 383-394.

Papanastasiou, Malvina and Koutsogiannaki, Sophia and Sarigiannis, Yiannis and Geisbrecht, Brian V. and Ricklin, Daniel and Lambris, John D.. (2017) Structural Implications for the Formation and Function of the Complement Effector Protein iC3b. Journal of immunology (Baltimore, Md. : 1950), 198 (8). pp. 3326-3335.

Primikyri, Alexandra and Papanastasiou, Malvina and Sarigiannis, Yiannis and Koutsogiannaki, Sophia and Reis, Edimara S. and Tuplano, Joel V. and Resuello, Ranillo R. G. and Nilsson, Bo and Ricklin, Daniel and Lambris, John D.. (2017) Method development and validation for the quantitation of the complement inhibitor Cp40 in human and cynomolgus monkey plasma by UPLC-ESI-MS. Journal of Chromatography B, 1041-1042. pp. 19-26.

Ricklin, Daniel and Barratt-Due, Andreas and Mollnes, Tom Eirik. (2017) Complement in clinical medicine: Clinical trials, case reports and therapy monitoring. Molecular Immunology, 89. pp. 10-21.

Wang, HongBin and Ricklin, Daniel and Lambris, John D.. (2017) Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proceedings of the National Academy of Sciences of the United States of America, 114 (41). pp. 10948-10953.

Xue, Xiaoguang and Wu, Jin and Ricklin, Daniel and Forneris, Federico and Di Crescenzio, Patrizia and Schmidt, Christoph Q. and Granneman, Joke and Sharp, Thomas H. and Lambris, John D. and Gros, Piet. (2017) Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses. Nature Structural and Molecular Biology, 24. pp. 643-651.

Yuan, Xiaopeng and Yang, Mingjuan and Chen, Xiang and Zhang, Xuhua and Sukhadia, Shrey and Musolino, Najia and Bao, Huijing and Chen, Tingtao and Xu, Chen and Wang, Qirui and Santoro, Stephen and Ricklin, Daniel and Hu, Jia and Lin, Ruihe and Yang, Wei and Li, Zhijun and Qin, Weijun and Zhao, Aizhi. (2017) Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy. Cancer Immunology, Immunotherapy, 66 (3). pp. 367-378.

Zhang, Pengfei and Hevey, Rachel and Ling, Chang-Chun. (2017) Total Synthesis of β-d-ido-Heptopyranosides Related to Capsular Polysaccharides of Campylobacter jejuni HS:4. The Journal of Organic Chemistry, 82 (18). pp. 9662-9674.

van Beek, Anna E. and Pouw, Richard B. and Brouwer, Mieke C. and van Mierlo, Gerard and Geissler, Judy and Ooijevaar-de Heer, Pleuni and de Boer, Martin and van Leeuwen, Karin and Rispens, Theo and Wouters, Diana and Kuijpers, Taco W.. (2017) Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma. Frontiers in Immunology, 8. p. 1328.

2016

Blöcher, René and Lamers, Christina and Wittmann, Sandra K. and Merk, Daniel and Hartmann, Markus and Weizel, Lilia and Diehl, Olaf and Brüggerhoff, Astrid and Boß, Marcel and Kaiser, Astrid and Schader, Tim and Göbel, Tamara and Grundmann, Manuel and Angioni, Carlo and Heering, Jan and Geisslinger, Gerd and Wurglics, Mario and Kostenis, Evi and Brüne, Bernhard and Steinhilber, Dieter and Schubert-Zsilavecz, Manfred and Kahnt, Astrid S. and Proschak, Ewgenij. (2016) N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators. Journal of medicinal chemistry, 59 (1). pp. 61-81.

Lamers, Christina and Merk, Daniel and Gabler, Matthias and Flesch, Daniel and Kaiser, Astrid and Schubert-Zsilavecz, Manfred. (2016) SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound. Future medicinal chemistry, 8 (2). pp. 133-148.

Pouw, Richard B. and Brouwer, Mieke C. and Geissler, Judy and van Herpen, Laurens V. and Zeerleder, Sacha S. and Wuillemin, Walter A. and Wouters, Diana and Kuijpers, Taco W.. (2016) Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3. PLoS ONE, 11 (3). e0152164.

Ricklin, Daniel and Lambris, John D.. (2016) Preformed mediators of defense-Gatekeepers enter the spotlight. Immunological Reviews, 274 (1). pp. 5-8.

Ricklin, Daniel and Reis, Edimara S. and Mastellos, Dimitrios C. and Gros, Piet and Lambris, John D.. (2016) Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense. Immunological Reviews , 274 (1). pp. 33-58.

Schmidt, Christoph Q. and Lambris, John D. and Ricklin, Daniel. (2016) Protection of host cells by complement regulators. Immunological Reviews, 274 (1). pp. 152-171.

Schäfer, Nicole and Grosche, Antje and Reinders, Joerg and Hauck, Stefanie M. and Pouw, Richard B. and Kuijpers, Taco W. and Wouters, Diana and Ehrenstein, Boris and Enzmann, Volker and Zipfel, Peter F. and Skerka, Christine and Pauly, Diana. (2016) Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases. Frontiers in immunology, 7. p. 542.

2015

Flesch, Daniel and Ness, Julia and Lamers, Christina and Dehm, Friederike and Popella, Sven and Steri, Ramona and Ogorek, Isabella and Hieke, Martina and Dannhardt, Gerd and Werz, Oliver and Weggen, Sascha and Schubert-Zsilavecz, Manfred. (2015) SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease. Bioorganic and Medicinal Chemistry Letters, 25 (4). pp. 841-846.

Keizer, Mischa P. and Pouw, Richard B. and Kamp, Angela M. and Patiwael, Sanne and Marsman, Gerben and Hart, Margreet H. and Zeerleder, Sacha and Kuijpers, Taco W. and Wouters, Diana. (2015) TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2. European journal of immunology, 45 (2). pp. 544-550.

Merk, Daniel and Lamers, Christina and Weber, Julia and Flesch, Daniel and Gabler, Matthias and Proschak, Ewgenij and Schubert-Zsilavecz, Manfred. (2015) Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands. Bioorganic & medicinal chemistry, 23 (3). pp. 499-514.

Pouw, R. B. and Vredevoogd, D. W. and Kuijpers, T. W. and Wouters, D.. (2015) Of mice and men: The factor H protein family and complement regulation. Molecular immunology, 67 (1). pp. 12-20.

2014

Hanke, Thomas and Lamers, Christina and Gomez, Roberto Carrasco and Schneider, Gisbert and Werz, Oliver and Schubert-Zsilavecz, Manfred. (2014) Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition. Bioorganic and Medicinal Chemistry Letters, 24 (16). pp. 3757-3763.

Lamers, Christina and Dittrich, Michaela and Steri, Ramona and Proschak, Ewgenij and Schubert-Zsilavecz, Manfred. (2014) Molecular determinants for improved activity at PPARα: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα. Bioorganic and Medicinal Chemistry Letters, 24 (16). pp. 4048-4052.

Lamers, Christina and Schubert-Zsilavecz, Manfred and Merk, Daniel. (2014) Medicinal chemistry and pharmacological effects of Farnesoid X Receptor (FXR) antagonists. Current Topics in Medicinal Chemistry, 14 (19). pp. 2188-2205.

Merk, Daniel and Gabler, Matthias and Gomez, Roberto Carrasco and Flesch, Daniel and Hanke, Thomas and Kaiser, Astrid and Lamers, Christina and Werz, Oliver and Schneider, Gisbert and Schubert-Zsilavecz, Manfred. (2014) Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR). Bioorganic & medicinal chemistry, 22 (8). pp. 2447-2460.

Merk, Daniel and Lamers, Christina and Ahmad, Khalil and Carrasco Gomez, Roberto and Schneider, Gisbert and Steinhilber, Dieter and Schubert-Zsilavecz, Manfred. (2014) Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist. Journal of Medicinal Chemistry, 57 (19). pp. 8035-8055.

Reker, Daniel and Perna, Anna M. and Rodrigues, Tiago and Schneider, Petra and Reutlinger, Michael and Mönch, Bettina and Koeberle, Andreas and Lamers, Christina and Gabler, Matthias and Steinmetz, Heinrich and Müller, Rolf and Schubert-Zsilavecz, Manfred and Werz, Oliver and Schneider, Gisbert. (2014) Revealing the macromolecular targets of complex natural products. Nature Chemistry, 6 (12). pp. 1072-1078.

2013

Flesch, Daniel and Merk, Daniel and Lamers, Christina and Schubert-Zsilavecz, Manfred. (2013) Novel prostaglandin receptor modulators - part II: EP receptor modulators; a patent review (2002 - 2012). Expert opinion on therapeutic patents, 23 (2). pp. 233-267.

Hevey, Rachel and Chen, Xining and Ling, Chang-Chun. (2013) Role of the 4,6-O-acetal in the regio- and stereoselective conversion of 2,3-di-O-sulfonyl-β-D-galactopyranosides to D-idopyranosides. Carbohydrate Research, 376. pp. 37-48.

Hevey, Rachel and Ling, Chang-Chun. (2013) Evidence of cation-coordination involvement in directing the regioselective di-inversion reaction of vicinal di-sulfonate esters. Organic & Biomolecular Chemistry, 11 (11). pp. 1887-1895.

Hevey, Rachel and Ling, Chang-Chun. (2013) Recent advances toward the development of inhibitors to attenuate tumor metastasis via the interruption of lectin-ligand interactions. Advances in carbohydrate chemistry and biochemistry, 69. pp. 125-207.

Lamers, Christina and Flesch, Daniel and Schubert-Zsilavecz, Manfred and Merk, Daniel. (2013) Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators. Expert opinion on therapeutic patents, 23 (1). pp. 47-77.

2012

Hevey, Rachel and Ling, Chang-Chun. (2012) Global financial challenge: opportunities for strengthening R&D research in targeted drug delivery. Future Medicinal Chemistry, 4 (1). pp. 1-5.

Hevey, Rachel and Ling, Chang-Chun. (2012) Recent advances in developing synthetic carbohydrate-based vaccines for cancer immunotherapies. Future Medicinal Chemistry, 4 (4). pp. 545-584.

Hevey, Rachel and Morland, Alizée and Ling, Chang-Chun. (2012) A scalable approach to obtaining orthogonally protected β-D-idopyranosides. Journal of Organic Chemistry, 77 (16). pp. 6760-6772.

Lamers, Christina and Schubert-Zsilavecz, Manfred and Merk, Daniel. (2012) Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008-present). Expert opinion on therapeutic patents, 22 (7). pp. 803-841.

la Buscató, Estel and Blöcher, René and Lamers, Christina and Klingler, Franca-Maria and Hahn, Steffen and Steinhilber, Dieter and Schubert-Zsilavecz, Manfred and Proschak, Ewgenij. (2012) Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors. Journal of Medicinal Chemistry, 55 (23). pp. 10771-10775.

2011

Feng, Jianhao and Hevey, Rachel and Ling, Chang-Chun. (2011) Synthesis of a Forssman antigen derivative for use in a conjugate vaccine. Carbohydrate Research, 346 (17). pp. 2650-2662.

Lamers, Christina and Schubert-Zsilavecz, Manfred. (2011) Medizinische Chemie der β2‐Sympathomimetika. Erfolge in der Rezeptor‐Strukturaufklärung. Pharmazie in unserer Zeit, 40 (5). pp. 423-428.

This list was generated on Thu Dec 2 03:47:09 2021 CET.