Items where Author is "Winzeler, E. A."

Article

Nguyen, W. and Dans, M. G. and Currie, I. and Awalt, J. K. and Bailey, B. L. and Lumb, C. and Ngo, A. and Favuzza, P. and Palandri, J. and Ramesh, S. and Penington, J. and Jarman, K. E. and Mukherjee, P. and Chakraborty, A. and Maier, A. G. and van Dooren, G. G. and Papenfuss, T. and Wittlin, S. and Churchyard, A. and Baum, J. and Winzeler, E. A. and Baud, D. and Brand, S. and Jackson, P. F. and Cowman, A. F. and Sleebs, B. E.. (2023) 7-N-substituted-3-oxadiazole quinolones with potent antimalarial activity target the cytochrome bc1 complex. ACS Infect Dis, 9 (3). pp. 668-691.

Imlay, L. S. and Lawong, A. K. and Gahalawat, S. and Kumar, A. and Xing, C. and Mittal, N. and Wittlin, S. and Churchyard, A. and Niederstrasser, H. and Crespo-Fernandez, B. and Posner, B. A. and Gamo, F. J. and Baum, J. and Winzeler, E. A. and Laleu, B. and Ready, J. M. and Phillips, M. A.. (2023) Fast-killing tyrosine amide ((S)-SW228703) with blood- and liver-stage antimalarial activity associated with the cyclic amine resistance locus (PfCARL). ACS Infect Dis, 9 (3). pp. 527-539.

Xie, S. C. and Metcalfe, R. D. and Dunn, E. and Morton, C. J. and Huang, S. C. and Puhalovich, T. and Du, Y. and Wittlin, S. and Nie, S. and Luth, M. R. and Ma, L. and Kim, M. S. and Pasaje, C. F. A. and Kumpornsin, K. and Giannangelo, C. and Houghton, F. J. and Churchyard, A. and Famodimu, M. T. and Barry, D. C. and Gillett, D. L. and Dey, S. and Kosasih, C. C. and Newman, W. and Niles, J. C. and Lee, M. C. S. and Baum, J. and Ottilie, S. and Winzeler, E. A. and Creek, D. J. and Williamson, N. and Parker, M. W. and Brand, S. and Langston, S. P. and Dick, L. R. and Griffin, M. D. W. and Gould, A. E. and Tilley, L.. (2022) Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science, 376 (6597). pp. 1074-1079.

Xie, S. C. and Metcalfe, R. D. and Mizutani, H. and Puhalovich, T. and Hanssen, E. and Morton, C. J. and Du, Y. and Dogovski, C. and Huang, S. C. and Ciavarri, J. and Hales, P. and Griffin, R. J. and Cohen, L. H. and Chuang, B. C. and Wittlin, S. and Deni, I. and Yeo, T. and Ward, K. E. and Barry, D. C. and Liu, B. and Gillett, D. L. and Crespo-Fernandez, B. F. and Ottilie, S. and Mittal, N. and Churchyard, A. and Ferguson, D. and Aguiar, A. C. C. and Guido, R. V. C. and Baum, J. and Hanson, K. K. and Winzeler, E. A. and Gamo, F. J. and Fidock, D. A. and Baud, D. and Parker, M. W. and Brand, S. and Dick, L. R. and Griffin, M. D. W. and Gould, A. E. and Tilley, L.. (2021) Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc Natl Acad Sci U S A, 118 (39). e2107213118.

Le Manach, C. and Dam, J. and Woodland, J. G. and Kaur, G. and Khonde, L. P. and Brunschwig, C. and Njoroge, M. and Wicht, K. J. and Horatscheck, A. and Paquet, T. and Boyle, G. A. and Gibhard, L. and Taylor, D. and Lawrence, N. and Yeo, T. and Mok, S. and Eastman, R. T. and Dorjsuren, D. and Talley, D. C. and Guo, H. and Simeonov, A. and Reader, J. and van der Watt, M. and Erlank, E. and Venter, N. and Zawada, J. W. and Aswat, A. and Nardini, L. and Coetzer, T. L. and Lauterbach, S. B. and Bezuidenhout, B. C. and Theron, A. and Mancama, D. and Koekemoer, L. L. and Birkholtz, L. M. and Wittlin, S. and Delves, M. and Ottilie, S. and Winzeler, E. A. and von Geldern, T. W. and Smith, D. and Fidock, D. A. and Street, L. J. and Basarab, G. S. and Duffy, J. and Chibale, K.. (2021) Identification and profiling of a novel diazaspiro[3.4]octane chemical series active against multiple stages of the human malaria parasite Plasmodium falciparum and optimization efforts. Journal of medicinal chemistry, 64 (4). pp. 2291-2309.

Palmer, M. J. and Deng, X. and Watts, S. and Krilov, G. and Gerasyuto, A. and Kokkonda, S. and El Mazouni, F. and White, J. and White, K. L. and Striepen, J. and Bath, J. and Schindler, K. A. and Yeo, T. and Shackleford, D. M. and Mok, S. and Deni, I. and Lawong, A. and Huang, A. and Chen, G. and Wang, W. and Jayaseelan, J. and Katneni, K. and Patil, R. and Saunders, J. and Shahi, S. P. and Chittimalla, R. and Angulo-Barturen, I. and Jimenez-Diaz, M. B. and Wittlin, S. and Tumwebaze, P. K. and Rosenthal, P. J. and Cooper, R. A. and Aguiar, A. C. C. and Guido, R. V. C. and Pereira, D. B. and Mittal, N. and Winzeler, E. A. and Tomchick, D. R. and Laleu, B. and Burrows, J. N. and Rathod, P. K. and Fidock, D. A. and Charman, S. A. and Phillips, M. A.. (2021) Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series. Journal of medicinal chemistry, 64 (9). pp. 6085-6136.

Nagle, A. and Wu, T. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Liu, B. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Chuan, T. and Alper, P. B. and Fischli, C. and Brun, R. and Lakshminarayana, S. B. and Rottmann, M. and Diagana, T. T. and Winzeler, E. A. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2012) Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of medicinal chemistry, 55 (9). pp. 4244-4273.

Delves, M. and Plouffe, D. and Scheurer, C. and Meister, S. and Wittlin, S. and Winzeler, E. A. and Sinden, R. E. and Leroy, D.. (2012) The activities of current antimalarial drugs on the life cycle stages of Plasmodium : a comparative study with human and rodent parasites. PLoS medicine, Vol. 9, H. 2 , e1001169.

Meister, S. and Plouffe, D. M. and Kuhen, K. L. and Bonamy, G. M. and Wu, T. and Barnes, S. W. and Bopp, S. E. and Borboa, R. and Bright, A. T. and Che, J. and Cohen, S. and Dharia, N. V. and Gagaring, K. and Gettayacamin, M. and Gordon, P. and Groessl, T. and Kato, N. and Lee, M. C. and McNamara, C. W. and Fidock, D. A. and Nagle, A. and Nam, T. G. and Richmond, W. and Roland, J. and Rottmann, M. and Zhou, B. and Froissard, P. and Glynne, R. J. and Mazier, D. and Sattabongkot, J. and Schultz, P. G. and Tuntland, T. and Walker, J. R. and Zhou, Y. and Chatterjee, A. and Diagana, T. T. and Winzeler, E. A.. (2011) Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science, Vol. 334, H. 6061. pp. 1372-1377.

Rottmann, M. and McNamara, C. and Yeung, B. K. and Lee, M. C. and Zou, B. and Russell, B. and Seitz, P. and Plouffe, D. M. and Dharia, N. V. and Tan, J. and Cohen, S. B. and Spencer, K. R. and Gonzalez-Paez G. E., and Lakshminarayana, S. B. and Goh, A. and Suwanarusk, R. and Jegla, T. and Schmitt, E. K. and Beck, H. P. and Brun, R. and Nosten, F. and Renia, L. and Dartois, V. and Keller, T. H. and Fidock, D. A. and Winzeler, E. A. and Diagana, T. T.. (2010) Spiroindolones, a potent compound class for the treatment of malaria. Science, Vol. 329, no. 5996. pp. 1175-1180.

Yeung, B. K. and Zou, B. and Rottmann, M. and Lakshminarayana, S. B. and Ang, S. H. and Leong, S. Y. and Tan, J. and Wong, J. and Keller-Maerki S., and Fischli, C. and Goh, A. and Schmitt, E. K. and Krastel, P. and Francotte, E. and Kuhen, K. and Plouffe, D. and Henson, K. and Wagner, T. and Winzeler, E. A. and Petersen, F. and Brun, R. and Dartois, V. and Diagana, T. T. and Keller, T. H.. (2010) Spirotetrahydro beta-carbolines (spiroindolones) : a new class of potent and orally efficacious compounds for the treatment of malaria. Journal of Medicinal Chemistry, 53 (14). pp. 5155-5164.