Items where Author is "Vennerstrom, J. L."

2023

Biendl, S. and Häberli, C. and Chen, G. and Wang, W. and Zhong, L. and Saunders, J. and Pham, T. and Wang, X. and Wu, J. and Charman, S. A. and Vennerstrom, J. L. and Keiser, J.. (2023) In vitro; and; in vivo; antischistosomal activity profiling and pharmacokinetics of ozonide carboxylic acids. ACS Infect Dis, 9 (3). pp. 643-652.

2022

Ren, R. and Wang, X. and Leas, D. A. and Häberli, C. and Cal, M. and Dong, Y. and Kaiser, M. and Keiser, J. and Vennerstrom, J. L.. (2022) Antischistosomal tetrahydro-γ-carboline sulfonamides. Bioorganic & medicinal chemistry letters, 59. p. 128546.

Dong, Y. and Sonawane, Y. and Maher, S. P. and Zeeman, A. M. and Chaumeau, V. and Vantaux, A. and Cooper, C. A. and Chiu, F. C. K. and Ryan, E. and McLaren, J. and Chen, G. and Wittlin, S. and Witkowski, B. and Nosten, F. and Sriraghavan, K. and Kyle, D. E. and Kocken, C. H. M. and Charman, S. A. and Vennerstrom, J. L.. (2022) Metabolic, pharmacokinetic, and activity profile of the liver stage antimalarial (RC-12). ACS Omega, 7 (14). pp. 12401-12411.

2021

Shackleford, D. M. and Chiu, F. C. K. and Katneni, K. and Blundell, S. and McLaren, J. and Wang, X. and Zhou, L. and Sriraghavan, K. and Alker, A. M. and Hunziker, D. and Scheurer, C. and Zhao, Q. and Dong, Y. and Mohrle, J. J. and Abla, N. and Matile, H. and Wittlin, S. and Vennerstrom, J. L. and Charman, S. A.. (2021) Cytochrome P450-mediated metabolism and CYP Inhibition for the synthetic peroxide antimalarial OZ439. ACS Infect Dis, 7 (7). pp. 1885-1893.

Leas, D. A. and Sanford, A. G. and Wu, J. and Cal, M. and Kaiser, M. and Wittlin, S. and Hemsley, R. M. and Darner, E. B. and Lui, L. M. and Davis, P. H. and Vennerstrom, J. L.. (2021) Diaryl ureas as an antiprotozoal chemotype. ACS Infect Dis, 7 (6). pp. 1578-1583.

2019

Wang, X. and Cal, M. and Kaiser, M. and Buckner, F. S. and Lepesheva, G. I. and Sanford, A. G. and Wallick, A. I. and Davis, P. H. and Vennerstrom, J. L.. (2019) A new chemotype with promise against Trypanosoma cruzi. Bioorganic & medicinal chemistry letters, 30. p. 126778.

2015

Wang, X. and Dong, Y. and Cal, M. and Kasier, M. and Wittling, S. and Vennerstrom, J. L.. (2015) Antiprotozoal selectivity of diimidazoline N-phenylbenzamides. ACS infectious diseases, 1. pp. 135-139.

2013

Wang, X. and Dong, Y. and Wittlin, S. and Charman, S. A. and Chiu, F. C. and Chollet, J. and Katneni, K. and Mannila, J. and Morizzi, J. and Ryan, E. and Scheurer, C. and Steuten, J. and Santo, Tomas J. and Snyder, C. and Vennerstrom, J. L.. (2013) Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres. Journal of medicinal chemistry, 56 (6). pp. 2547-2555.

Moehrle, J. J. and Duparc, S. and Siethoff, C. and van Giersbergen, P. L. and Craft, J. C. and Arbe-Barnes, S. and Charman, S. A. and Gutierrez, M. and Wittlin, S. and Vennerstrom, J. L.. (2013) First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials. British journal of clinical pharmacology, Vol. 75, H. 2. pp. 535-548.

2011

Kirchhofer, C. and Vargas, M. and Braissant, O. and Dong, Y. and Wang, X. and Vennerstrom, J. L. and Keiser, J.. (2011) Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin, 118 (1). pp. 56-62.

Keiser, J. and Ingram, K. and Vargas, M. and Chollet, J. and Wang, X. and Dong, Y. and Vennerstrom, J. L.. (2011) In Vivo Activity of Aryl Ozonides against Schistosoma Species. Antimicrobial agents and chemotherapy, 56 (2). pp. 1090-1092.

Charman, S. A. and Arbe-Barnes S., and Bathurst, I. C. and Brun, R. and Campbell, M. and Charman, W. N. and Chiu, F. C. and Chollet, J. and Craft, J. C. and Creek, D. J. and Dong, Y. and Matile, H. and Maurer, M. and Morizzi, J. and Nguyen, T. and Papastogiannidis, P. and Scheurer, C. and Shackleford, D. M. and Sriraghavan, K. and Stingelin, L. and Tang, Y. and Urwyler, H. and Wang, X. and White, K. L. and Wittlin, S. and Zhou, L. and Vennerstrom, J. L.. (2011) Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 11. pp. 4400-4405.

2010

Keiser, J. and Vargas, M. and Vennerstrom, J. L.. (2010) Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice. The journal of antimicrobial chemotherapy, Vol. 65, H. 9. pp. 1991-1995.

Dong, Y. and Chollet, J. and Vargas, M. and Mansour, N. R. and Bickle, Q. and Alnouti, Y. and Huang, J. and Keiser, J. and Vennerstrom, J. L.. (2010) Praziquantel analogs with activity against juvenile Schistosoma mansoni. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 20, H. 8. pp. 2481-2484.

Tang, Y. and Wittlin, S. and Charman, S. A. and Chollet, J. and Chiu, F. C. and Morizzi, J. and Johnson, L. M. and Tomas, J. S. and Scheurer, C. and Snyder, C. and Zhou, L. and Dong, Y. and Charman, W. N. and Matile, H. and Urwyler, H. and Dorn, A. and Vennerstrom, J. L.. (2010) The comparative antimalarial properties of weak base and neutral synthetic ozonides. Bioorganic and Medicinal Chemistry Letters, Vol. 20, H. 2. pp. 563-566.

Dong, Y. and McCullough, K. J. and Wittlin, S. and Chollet, J. and Vennerstrom, J. L.. (2010) The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone. Bioorganic and Medicinal Chemistry Letters, Vol. 20, H. 22. pp. 6359-6361.

Dong, Y. and Wittlin, S. and Sriraghavan, K. and Chollet, J. and Charman, S. A. and Charman, W. N. and Scheurer, C. and Urwyler, H. and Santo, T. J. and Snyder, C. and Creek, D. J. and Morizzi, J. and Koltun, M. and Matile, H. and Wang, X. and Padmanilayam, M. and Tang, Y. and Dorn, A. and Brun, R. and Vennerstrom, J. L.. (2010) The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). Journal of Medicinal Chemistry, 53 (1). pp. 481-491.

2009

Wang, X. and Creek, D. J. and Schiaffo, C. E. and Dong, Y. and Chollet, J. and Scheurer, C. and Wittlin, S. and Charman, S. A. and Dussault, P. H. and Wood, J. K. and Vennerstrom, J. L.. (2009) Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs : relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 16. pp. 4542-4545.