Items where Author is "Sharpe, Timothy D."

2021

Scott, Duncan E. and Francis-Newton, Nicola J. and Marsh, May E. and Coyne, Anthony G. and Fischer, Gerhard and Moschetti, Tommaso and Bayly, Andrew R. and Sharpe, Timothy D. and Haas, Kalina T. and Barber, Lorraine and Valenzano, Chiara R. and Srinivasan, Rajavel and Huggins, David J. and Lee, Miyoung and Emery, Amy and Hardwick, Bryn and Ehebauer, Matthias and Dagostin, Claudio and Esposito, Alessandro and Pellegrini, Luca and Perrior, Trevor and McKenzie, Grahame and Blundell, Tom L. and Hyvönen, Marko and Skidmore, John and Venkitaraman, Ashok R. and Abell, Chris. (2021) A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell chemical biology, 28 (6). pp. 835-847.e5.

2018

Canning, Peter and Park, Kwangjin and Gonçalves, João and Li, Chunmei and Howard, Conor J. and Sharpe, Timothy D. and Holt, Liam J. and Pelletier, Laurence and Bullock, Alex N. and Leroux, Michel R.. (2018) CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Reports, 22 (4). pp. 885-894.

2017

Dixon-Clarke, Sarah E. and Shehata, Saifeldin N. and Krojer, Tobias and Sharpe, Timothy D. and von Delft, Frank and Sakamoto, Kei and Bullock, Alex N.. (2017) Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. Biochemical Journal, 474 (5). pp. 699-713.

2013

Smith, Clive A. and Li, Xin and Mize, Todd H. and Sharpe, Timothy D. and Graziani, Edmund I. and Abell, Chris and Huck, Wilhelm T. S.. (2013) Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry. Analytical Chemistry, 85 (8). pp. 3812-3816.

2012

Adams, Cassandra J. and Pike, Ashley C. W. and Maniam, Sandra and Sharpe, Timothy D. and Coutts, Amanda S. and Knapp, Stefan and La Thangue, Nicholas B. and Bullock, Alex N.. (2012) The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Proceedings of the National Academy of Sciences, 109 (10). pp. 3778-3783.

2010

Arbely, Eyal and Rutherford, Trevor J. and Neuweiler, Hannes and Sharpe, Timothy D. and Ferguson, Neil and Fersht, Alan R.. (2010) Carboxyl pK(a) values and acid denaturation of BBL. Journal of Molecular Biology, 403 (2). pp. 313-327.

Filippakopoulos, Panagis and Low, Andrew and Sharpe, Timothy D. and Uppenberg, Jonas and Yao, Shenggen and Kuang, Zhihe and Savitsky, Pavel and Lewis, Rowena S. and Nicholson, Sandra E. and Norton, Raymond S. and Bullock, Alex N.. (2010) Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. Journal of Molecular Biology, 401 (3). pp. 389-402.

Arbely, Eyal and Neuweiler, Hannes and Sharpe, Timothy D. and Johnson, Christopher M. and Fersht, Alan R.. (2010) The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces. Protein Science, 19 (9). pp. 1704-1713.

2009

Arbely, Eyal and Rutherford, Trevor J. and Sharpe, Timothy D. and Ferguson, Neil and Fersht, Alan R.. (2009) Downhill versus barrier-limited folding of BBL 1: energetic and structural perturbation effects upon protonation of a histidine of unusually low pKa. Journal of Molecular Biology, 387 (4). pp. 986-992.

Neuweiler, Hannes and Sharpe, Timothy D. and Johnson, Christopher M. and Teufel, Daniel P. and Ferguson, Neil and Fersht, Alan R.. (2009) Downhill versus barrier-limited folding of BBL 2: mechanistic insights from kinetics of folding monitored by independent tryptophan probes. Journal of Molecular Biology, 387 (4). pp. 975-985.

Neuweiler, Hannes and Sharpe, Timothy D. and Rutherford, Trevor J. and Johnson, Christopher M. and Allen, Mark D. and Ferguson, Neil and Fersht, Alan R.. (2009) The folding mechanism of BBL: Plasticity of transition-state structure observed within an ultrafast folding protein family. Journal of Molecular Biology, 390 (5). pp. 1060-1073.

2008

Sharpe, Timothy D. and Ferguson, Neil and Johnson, Christopher M. and Fersht, Alan R.. (2008) Conservation of transition state structure in fast folding peripheral subunit-binding domains. Journal of Molecular Biology, 383 (1). pp. 224-237.

2007

Huang, Fang and Sato, Satoshi and Sharpe, Timothy D. and Ying, Liming and Fersht, Alan R.. (2007) Distinguishing between cooperative and unimodal downhill protein folding. Proceedings of the National Academy of Sciences of the United States of America, 104 (1). pp. 123-127.

Ferguson, Neil and Sharpe, Timothy D. and Johnson, Christopher M. and Schartau, Pamela J. and Fersht, Alan R.. (2007) Structural biology: analysis of `downhill` protein folding. Nature, 445 (7129). E14-E15.

2006

Ferguson, Neil and Becker, Johanna and Tidow, Henning and Tremmel, Sandra and Sharpe, Timothy D. and Krause, Gerd and Flinders, Jeremy and Petrovich, Miriana and Berriman, John and Oschkinat, Hartmut and Fersht, Alan R.. (2006) General structural motifs of amyloid protofilaments. Proceedings of the National Academy of Sciences of the United States of America, 103 (44). pp. 16248-16253.

Ferguson, Neil and Sharpe, Timothy D. and Johnson, Christopher M. and Fersht, Alan R.. (2006) The transition state for folding of a peripheral subunit-binding domain contains robust and ionic-strength dependent characteristics. Journal of Molecular Biology, 356 (5). pp. 1237-1247.

2005

Ferguson, Neil and Sharpe, Timothy D. and Schartau, Pamela J. and Sato, Satoshi and Allen, Mark D. and Johnson, Christopher M. and Rutherford, Trevor J. and Fersht, Alan R.. (2005) Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family. Journal of Molecular Biology, 353 (2). pp. 427-446.

2004

Ferguson, Neil and Schartau, Pamela J. and Sharpe, Timothy D. and Sato, Satoshi and Fersht, Alan R.. (2004) One-state downhill versus conventional protein folding. Journal of Molecular Biology, 344 (2). pp. 295-301.

2003

Ferguson, Neil and Berriman, John and Petrovich, Miriana and Sharpe, Timothy D. and Finch, John T. and Fersht, Alan R.. (2003) Rapid amyloid fiber formation from the fast-folding WW domain FBP28. Proceedings of the National Academy of Sciences of the United States of America, 100 (17). pp. 9814-9819.