Items where Author is "Sharpe, Timothy"

2022

Collu, Gabriella and Bierig, Tobias and Krebs, Anna-Sophia and Engilberge, Sylvain and Varma, Niveditha and Guixà-González, Ramon and Sharpe, Timothy and Deupi, Xavier and Olieric, Vincent and Poghosyan, Emiliya and Benoit, Roger M.. (2022) Chimeric single α-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology. Structure, 30 (1). pp. 95-106.e7.

Abiko, Layara Akemi and Dias Teixeira, Raphael and Engilberge, Sylvain and Grahl, Anne and Mühlethaler, Tobias and Sharpe, Timothy and Grzesiek, Stephan. (2022) Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol. Nature Chemistry, 14 (10). pp. 1133-1141.

2021

Li-Blatter, Xiaochun and Zweifel, Ludovit and Sharpe, Timothy. (2021) A Familiar Protein-Ligand Interaction Revisited with Multiple Methods. Methods in Molecular Biology, 2263. pp. 47-79.

Cramer, Jonathan and Aliu, Butrint and Jiang, Xiaohua and Sharpe, Timothy and Pang, Lijuan and Hadorn, Adrian and Rabbani, Said and Ernst, Beat. (2021) Poly-l-lysine Glycoconjugates Inhibit DC-SIGN-mediated Attachment of Pandemic Viruses. ChemMedChem, 16 (15). pp. 2345-2353.

2020

Grahl, Anne and Abiko, Layara Akemi and Isogai, Shin and Sharpe, Timothy and Grzesiek, Stephan. (2020) A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR. Nature communications, 11 (1). p. 2216.

Fiedler, Thomas and Fabrice, Tohnyui Ndinyanka and Studer, Vera and Vinet, Adrien and Faltova, Lenka and Kammerer, Richard A. and Steinmetz, Michel O. and Sharpe, Timothy and Pieters, Jean. (2020) Homodimerization of coronin A through the C-terminal coiled-coil domain is essential for multicellular differentiation of Dictyostelium discoideum. FEBS Letters, 594 (13). pp. 2116-2127.

Mas, Guillaume and Burmann, Björn M. and Sharpe, Timothy and Claudi, Beatrice and Bumann, Dirk and Hiller, Sebastian. (2020) Regulation of chaperone function by coupled folding and oligomerization. Science advances, 6 (43). eabc5822.

Rath, Parthasarathi and Sharpe, Timothy and Hiller, Sebastian. (2020) The electrostatic core of the outer membrane protein X from E. coli. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1862 (1). p. 183031.

2019

Stress, Cedric J. and Sauter, Basilius and Schneider, Lukas A. and Sharpe, Timothy and Gillingham, Dennis. (2019) A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles. Angewandte Chemie International Edition, 58 (28). pp. 9570-9574.

Luther, Anatol and Urfer, Matthias and Zahn, Michael and Müller, Maik and Wang, Shuang-Yan and Mondal, Milon and Vitale, Alessandra and Hartmann, Jean-Baptiste and Sharpe, Timothy and Monte, Fabio Lo and Kocherla, Harsha and Cline, Elizabeth and Pessi, Gabriella and Rath, Parthasarathi and Modaresi, Seyed Majed and Chiquet, Petra and Stiegeler, Sarah and Verbree, Carolin and Remus, Tobias and Schmitt, Michel and Kolopp, Caroline and Westwood, Marie-Anne and Desjonquères, Nicolas and Brabet, Emile and Hell, Sophie and LePoupon, Karen and Vermeulen, Annie and Jaisson, Régis and Rithié, Virginie and Upert, Grégory and Lederer, Alexander and Zbinden, Peter and Wach, Achim and Moehle, Kerstin and Zerbe, Katja and Locher, Hans H. and Bernardini, Francesca and Dale, Glenn E. and Eberl, Leo and Wollscheid, Bernd and Hiller, Sebastian and Robinson, John A. and Obrecht, Daniel. (2019) Chimeric peptidomimetic antibiotics against Gram-negative bacteria. Nature, 576 (7787). pp. 452-458.

Rath, Parthasarathi and Sharpe, Timothy and Kohl, Bastian and Hiller, Sebastian. (2019) Two-state folding of the outer membrane protein X into a lipid bilayer membrane. Angewandte Chemie International Edition, 58 (9). pp. 2665-2669.

2018

Zihlmann, Pascal and Silbermann, Marleen and Sharpe, Timothy and Jiang, Xiaohua and Mühlethaler, Tobias and Jakob, Roman P. and Rabbani, Said and Sager, Christoph P. and Frei, Priska and Pang, Lijuan and Maier, Timm and Ernst, Beat. (2018) KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists. Chemistry (Weinheim an der Bergstrasse, Germany), 24. pp. 1-10.

Kuenzl, Tilmann and Li-Blatter, Xiaochun and Srivastava, Puneet and Herdewijn, Piet and Sharpe, Timothy and Panke, Sven. (2018) Mutant Variants of the Substrate-Binding Protein DppA from Escherichia coli Enhance Growth on Nonstandard γ-Glutamyl Amide-Containing Peptides. Applied and Environmental Microbiology, 84 (13). e00340-18.

Johnson, Christopher and Sharpe, Timothy. (2018) Protein Folding, Energy Landscapes and Downhill Protein Folding Scenarios. In: Encyclopedia of Biophysics. Berlin, pp. 1-19.

2017

Morgado, Leonor and Burmann, Björn M. and Sharpe, Timothy and Mazur, Adam and Hiller, Sebastian. (2017) The dynamic dimer structure of the chaperone Trigger Factor. Nature Communications, 8. p. 1992.

2016

He, Lichun and Sharpe, Timothy and Mazur, Adam and Hiller, Sebastian. (2016) A molecular mechanism of chaperone–client recognition. Science Advances, 2 (11). e1601625.

Moschetti, Tommaso and Sharpe, Timothy and Fischer, Gerhard and Marsh, May E. and Ng, Hong Kin and Morgan, Matthew and Scott, Duncan E. and Blundell, Tom L. and R. Venkitaraman, Ashok and Skidmore, John and Abell, Chris and Hyvönen, Marko. (2016) Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. Journal of Molecular Biology, 428 (23). pp. 4589-4607.

Stanger, Frédéric V. and Burmann, Björn M. and Harms, Alexander and Aragão, Hugo and Mazur, Adam and Sharpe, Timothy and Dehio, Christoph and Hiller, Sebastian and Schirmer, Tilman. (2016) Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proceedings of the National Academy of Sciences of the United States of America, 113 (5). E529-E537.

Benjamin, Don and Colombi, Marco and Hindupur, Sravanth K. and Betz, Charles and Lane, Heidi A. and El-Shemerly, Mahmoud Y. M. and Lu, Min and Quagliata, Luca and Terracciano, Luigi and Moes, Suzette and Sharpe, Timothy and Wodnar-Filipowicz, Aleksandra and Moroni, Christoph and Hall, Michael N.. (2016) Syrosingopine sensitizes cancer cells to killing by metformin. Science Advances, 2 (12). e1601756.

2015

Kleeb, Simon and Pang, Lijuan and Mayer, Katharina and Eris, Deniz and Sigl, Anja and Preston, Roland C. and Zihlmann, Pascal and Sharpe, Timothy and Jakob, Roman P. and Abgottspon, Daniela and Hutter, Aline S. and Scharenberg, Meike and Jiang, Xiaohua and Navarra, Giulio and Rabbani, Said and Smiesko, Martin and Lüdin, Nathalie and Bezençon, Jacqueline and Schwardt, Oliver and Maier, Timm and Ernst, Beat. (2015) FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile. Journal of Medicinal Chemistry, 58 (5). pp. 2221-2239.

2014

Sundriyal, Amit and Massa, Claudia and Samoray, Dietrich and Zehender, Fabian and Sharpe, Timothy and Jenal, Urs and Schirmer, Tilman. (2014) Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP. Journal of Biological Chemistry, 289 (10). pp. 6978-6990.