Items where Author is "Krähenbühl, Stephan"

2022

Roos, Noëmi Johanna and Mancuso, Riccardo Vincenzo and Sanvee, Gerda Mawududzi and Bouitbir, Jamal and Krähenbühl, Stephan. (2022) Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food and Chemical Toxicology, 162. p. 112869.

Bouitbir, Jamal and Panajatovic, Miljenko V. and Krähenbühl, Stephan. (2022) Mitochondrial Toxicity Associated with Imatinib and Sorafenib in Isolated Rat Heart Fibers and the Cardiomyoblast H9c2 Cell Line. International journal of molecular sciences, 23 (4). p. 2282.

2021

Leuppi-Taegtmeyer, Anne B. and Reinau, Daphne and Yilmaz, Stella and Rüegg, Stephan and Krähenbühl, Stephan and Jick, Susan S. and Leuppi, Jörg D. and Meier, Christoph R.. (2021) Antiseizure drugs and risk of developing smoking-related chronic obstructive pulmonary disease or lung cancer: A population-based case-control study. British Journal of Clinical Pharmacology, 87 (3). pp. 1253-1263.

Blaser, Lea S. and Duthaler, Urs and Bouitbir, Jamal and Leuppi-Taegtmeyer, Anne B. and Liakoni, Evangelia and Dolf, Reto and Mayr, Michael and Drewe, Jürgen and Krähenbühl, Stephan and Haschke, Manuel. (2021) Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study. Frontiers in Pharmacology, 12. p. 620635.

Panajatovic, Miljenko V. and Singh, Francois and Krähenbühl, Stephan and Bouitbir, Jamal. (2021) Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression. International Journal of Molecular Siences, 22 (9). p. 4950.

Bachmann, Fabio and Duthaler, Urs and Meyer Zu Schwabedissen, Henriette E. and Puchkov, Maxim and Huwyler, Jörg and Haschke, Manuel and Krähenbühl, Stephan. (2021) Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2. Clinical Pharmacology and Therapeutics, 109 (6). pp. 1505-1516.

Witzigmann, Dominik and Grossen, Philip and Quintavalle, Cristina and Lanzafame, Manuela and Schenk, Susanne H. and Tran, Xue-Ting and Englinger, Bernhard and Hauswirth, Patrick and Grünig, David and van Schoonhoven, Sushilla and Krähenbühl, Stephan and Terracciano, Luigi M. and Berger, Walter and Piscuoglio, Salvatore and Quagliata, Luca and Rommelaere, Jean and Nüesch, Jürg P. F. and Huwyler, Jörg. (2021) Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma. Journal of Controlled Release, 334. pp. 138-152.

Mueller, Alexandra M. and Liakoni, Evangelia and Schneider, Cornelia and Burkard, Theresa and Jick, Susan S. and Krähenbühl, Stephan and Meier, Christoph R. and Spoendlin, Julia. (2021) The Risk of Muscular Events Among New Users of Hydrophilic and Lipophilic Statins: an Observational Cohort Study. Journal of General Internal Medicine, 36 (9). pp. 2639-2647.

Duthaler, Urs and Weber, Michael and Hofer, Lorenz and Chaccour, Carlos and Maia, Marta and Müller, Pie and Krähenbühl, Stephan and Hammann, Felix. (2021) The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes. PLoS Pathogens, 17 (3). e1009382.

2020

Mancuso, Riccardo V. and Casper, Jens and Schmidt, Albrecht G. and Krähenbühl, Stephan and Weitz-Schmidt, Gabriele. (2020) Anti-αLβ2 antibodies reveal novel endocytotic cross-modulatory functionality. British Journal of Pharmacology, 177 (12). pp. 2696-2711.

Zhou, Xun and Bouitbir, Jamal and Liechti, Matthias E. and Krähenbühl, Stephan and Mancuso, Riccardo V.. (2020) Hyperthermia Increases Neurotoxicity Associated with Novel Methcathinones. Cells, 9 (4). p. 965.

Bouitbir, Jamal and Panajatovic, Miljenko Valentin and Frechard, Theo and Roos, Noëmi Johanna and Krähenbühl, Stephan. (2020) Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells. Frontiers in Pharmacology, 11. p. 1106.

Roos, Noëmi Johanna and Aliu, Diell and Bouitbir, Jamal and Krähenbühl, Stephan. (2020) Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells. Frontiers in pharmacology, 11. p. 944.

Bouitbir, Jamal and Alshaikhali, Abdallah and Panajatovic, Miljenko V. and Abegg, Vanessa F. and Paech, Franziska and Krähenbühl, Stephan. (2020) Mechanisms of Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in H9c2 Cells and Mice. European cardiology, 15. e33.

Panajatovic, Miljenko Valentin and Singh, François and Roos, Noëmi Johanna and Duthaler, Urs and Handschin, Christoph and Krähenbühl, Stephan and Bouitbir, Jamal. (2020) PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice. Acta physiologica (Oxford, England), 228 (4). e13402.

Zhou, Xun and Bouitbir, Jamal and Liechti, Matthias E. and Krähenbühl, Stephan and Mancuso, Riccardo V.. (2020) Para; -Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells. International journal of molecular sciences, 21 (8). p. 2841.

Suenderhauf, Claudia and Berger, Benjamin and Puchkov, Maxim and Schmid, Yasmin and Müller, Sabine and Huwyler, Jörg and Haschke, Manuel and Krähenbühl, Stephan and Duthaler, Urs. (2020) Pharmacokinetics and phenotyping properties of the "Basel" phenotyping cocktail combination capsule in healthy male adults. British journal of clinical pharmacology, 86 (2). pp. 352-361.

Rudin, Deborah and Schmutz, Maurice and Roos, Noëmi Johanna and Bouitbir, Jamal and Krähenbühl, Stephan. (2020) Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis. Biomedicines, 8 (7). p. 212.

Panajatovic, Miljenko V. and Singh, François and Duthaler, Urs and Krähenbühl, Stephan and Bouitbir, Jamal. (2020) Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced Myotoxicity. European cardiology, 15. e35.

Panajatovic, Miljenko Valentin and Singh, François and Krähenbühl, Stephan and Bouitbir, Jamal. (2020) Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle Expression. Biomedicines, 8 (9). p. 351.

Roos, Noëmi Johanna and Duthaler, Urs and Bouitbir, Jamal and Krähenbühl, Stephan. (2020) The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells. Free radical biology and medicine, 152. pp. 216-226.

2019

Brecht, Karin and Kirchhofer, Carla and Bouitbir, Jamal and Trapani, Francesca and Keiser, Jennifer and Krähenbühl, Stephan. (2019) Exogenous iron increases fasciocidal activity and hepatocellular toxicity of the synthetic endoperoxides OZ78 and MT04. International Journal of Molecular Sciences, 20 (19). p. 4880.

Bühler, Tim and Medinger, Michael and Bouitbir, Jamal and Krähenbühl, Stephan and Leuppi-Taegtmeyer, Anne. (2019) Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient. Frontiers in pharmacology, 10. p. 645.

Sanvee, Gerda M. and Bouitbir, Jamal and Krähenbühl, Stephan. (2019) Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells. Scientific reports, 9 (1). p. 7409.

Sanvee, Gerda M. and Panajatovic, Miljenko V. and Bouitbir, Jamal and Krähenbühl, Stephan. (2019) Mechanisms of insulin resistance by simvastatin in C2C12 myotubes and in mouse skeletal muscle. Biochemical pharmacology, 164. pp. 23-33.

Bouitbir, Jamal and Sanvee, Gerda M. and Panajatovic, Miljenko V. and Singh, François and Krähenbühl, Stephan. (2019) Mechanisms of statin-associated skeletal muscle-associated symptoms. Pharmacological research (154). p. 104201.

Rudin, Deborah and Spoendlin, Julia and Cismaru, Anca L. and Liakoni, Evangelia and Bonadies, Nicolas and Amstutz, Ursula and Meier, Christoph R. and Krähenbühl, Stephan and Haschke, Manuel. (2019) Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients. European journal of internal medicine, 68. pp. 36-43.

Kiene, Klara and Hayasi, Noriyuki and Burhenne, Jürgen and Uchitomi, Ryo and Sünderhauf, Claudia and Schmid, Yasmin and Haschke, Manuel and Haefeli, Walter Emil and Krähenbühl, Stephan and Mikus, Gerd and Inada, Hirohiko and Huwyler, Jörg. (2019) Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film. European Journal of Pharmaceutical Sciences, 135. pp. 77-82.

Bouitbir, Jamal and Alshaikhali, Abdallah and Panajatovic, Miljenko V. and Abegg, Vanessa F. and Paech, Franziska and Krähenbühl, Stephan. (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib: Running title: Sunitinib and oxidative stress in hearts. Toxicology, 426. p. 152281.

Zhou, Xun and Luethi, Dino and Sanvee, Gerda M. and Bouitbir, Jamal and Liechti, Matthias E. and Krähenbühl, Stephan. (2019) Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts. International journal of molecular sciences, 20 (7). p. 1561.

Rudin, Deborah and Lanzilotto, Angelo and Bachmann, Fabio and Housecroft, Catherine E. and Constable, Edwin C. and Drewe, Jürgen and Haschke, Manuel and Krähenbühl, Stephan. (2019) Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells. Biochemical Pharmacology, 163. pp. 345-356.

Malagnino, Vanessa and Duthaler, Urs and Seibert, Isabell and Krähenbühl, Stephan and Meyer Zu Schwabedissen, Henriette E.. (2019) OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe. Molecular Pharmacology, 96 (2). pp. 128-137.

Singh, François and Zoll, Joffrey and Duthaler, Urs and Charles, Anne-Laure and Panajatovic, Miljenko V. and Laverny, Gilles and McWilliams, Thomas G. and Metzger, Daniel and Geny, Bernard and Krähenbühl, Stephan and Bouitbir, Jamal. (2019) PGC-1β modulates statin-associated myotoxicity in mice. Archives of Toxicology, 93 (2). pp. 487-504.

Leuppi-Taegtmeyer, Anne and Duthaler, Urs and Hammann, Felix and Schmid, Yasmin and Dickenmann, Michael and Amico, Patricia and Jehle, Andreas W. and Kalbermatter, Stefan and Lenherr, Christoph and Meyer Zu Schwabedissen, Henriette E. and Haschke, Manuel and Liechti, Matthias E. and Krähenbühl, Stephan. (2019) Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions. Nephrology, Dialysis, Transplantation, 34 (4). pp. 692-702.

Schmid, Yasmin and Navarini, Alexander and Manjaly Thomas, Zita-Rose and Pfleiderer, Bettina and Krähenbühl, Stephan and Mueller, Simon M.. (2019) Sex differences in the pharmacology of itch therapies - a narrative review. Current Opinion in Pharmacology, 46. pp. 122-142.

2018

Berger, Benjamin and Bachmann, Fabio and Duthaler, Urs and Krähenbühl, Stephan and Haschke, Manuel. (2018) Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug. Frontiers in pharmacology, 9. p. 774.

Grünig, David and Duthaler, Urs and Krähenbühl, Stephan. (2018) Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells. Frontiers in pharmacology, 9. p. 257.

Grünig, David and Felser, Andrea and Duthaler, Urs and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicological sciences, 164 (2). pp. 477-488.

Paech, Franziska and Mingard, Cécile and Grünig, David and Abegg, Vanessa F. and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicology, 395. pp. 34-44.

Mingard, Cécile and Paech, Franziska and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines. Journal of applied toxicology : JAT, 38 (3). pp. 418-431.

Bachmann, Fabio and Duthaler, Urs and Rudin, Deborah and Krähenbühl, Stephan and Haschke, Manuel. (2018) N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 120. pp. 172-180.

Luethi, Dino and Kolaczynska, Karolina E. and Docci, Luca and Krähenbühl, Stephan and Hoener, Marius C. and Liechti, Matthias E.. (2018) Pharmacological profile of mephedrone analogs and related new psychoactive substances. Neuropharmacology, 134 (Part A). pp. 4-12.

Luethi, Dino and Kaeser, Philine J. and Brandt, Simon D. and Krähenbühl, Stephan and Hoener, Marius C. and Liechti, Matthias E.. (2018) Pharmacological profile of methylphenidate-based designer drugs. Neuropharmacology, 134 (Part A). pp. 133-140.

Duthaler, Urs and Suenderhauf, Claudia and Karlsson, Mats O. and Hussner, Janine and Meyer Zu Schwabedissen, Henriette and Krähenbühl, Stephan and Hammann, Felix. (2018) Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers. British journal of clinical pharmacology, 85 (3). pp. 626-633.

Paech, Franziska and Abegg, Vanessa F. and Duthaler, Urs and Terracciano, Luigi and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology, 409. pp. 13-23.

Duthaler, Urs and Berger, Benjamin and Erb, Stefan and Battegay, Manuel and Letang, Emili and Gaugler, Stefan and Natamatungiro, Alex and Mnzava, Dorcas and Donzelli, Massimiliano and Krähenbühl, Stephan and Haschke, Manuel. (2018) Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions. Journal of Antimicrobial Chemotherapy, 73 (10). pp. 2729-2737.

2017

Brueckner, David and Solokhina, Anna and Krähenbühl, Stephan and Braissant, Olivier. (2017) A combined application of tunable diode laser absorption spectroscopy and isothermal micro-calorimetry for calorespirometric analysis. Journal of Microbiological Methods, 139. pp. 210-214.

Brueckner, David and Krähenbühl, Stephan and Zuber, Ulrich and Bonkat, Gernot and Braissant, Olivier. (2017) An alternative sterility assessment for parenteral drug products using isothermal microcalorimetry. Journal of Applied Microbiology, 123 (3). pp. 773-779.

Duthaler, Urs and Berger, Benjamin and Erb, Stefan and Battegay, Manuel and Letang, Emilio and Gaugler, Stefan and Krähenbühl, Stephan and Haschke, Manuel. (2017) Automated high throughput analysis of antiretroviral drugs in dried blood spots. Journal of Mass Spectrometry, 52 (8). pp. 534-542.

Haegler, Patrizia and Grünig, David and Berger, Benjamin and Terracciano, Luigi and Krähenbühl, Stephan and Bouitbir, Jamal. (2017) Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice. PLoS One, 12 (1). e0171026.

Paech, Franziska and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis. Frontiers in Pharmacology, 8. p. 367.

Haegler, Patrizia and Joerin, Lorenz and Krähenbühl, Stephan and Bouitbir, Jamal. (2017) Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents. Toxicological sciences, 157 (1). pp. 183-195.

Bonifacio, Annalisa and Sanvee, Gerda M. and Brecht, Karin and Kratschmar, Denise V. and Odermatt, Alex and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes. Archives of Toxicology, 91 (5). pp. 2223-2234.

Krähenbühl, Stephan. (2017) Importance of the skeletal muscle carnitine stores in fuel selection. The Journal of Physiology, 595 (17). pp. 5727-5728.

Blaser, Lea and Hassna, Hala and Hofmann, Sarah and Holbro, Andreas and Haschke, Manuel and Rätz Bravo, Alexandra and Zeller, Andreas and Krähenbühl, Stephan and Taegtmeyer, Anne. (2017) Leucopenia associated with metamizole: a case-control study. Swiss medical weekly, 147. w14438.

Luethi, Dino and Liechti, Matthias E. and Krähenbühl, Stephan. (2017) Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones. Toxicology, 387. pp. 57-66.

Paech, Franziska and Messner, Simon and Spickermann, Jochen and Wind, Mathias and Schmitt-Hoffmann, Anne-Hortense and Witschi, Anne Therese and Howell, Brett A. and Church, Rachel J. and Woodhead, Jeff and Engelhardt, Marc and Krähenbühl, Stephan and Maurer, Martina. (2017) Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072. Archives of Toxicology, 91 (11). pp. 3647-3662.

Brecht, Karin and Riebel, Virginie and Couttet, Philippe and Paech, Franziska and Wolf, Armin and Chibout, Salah-Dine and Pognan, Francois and Krähenbühl, Stephan and Uteng, Marianne. (2017) Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Toxicology in Vitro, 40. pp. 55-65.

Krähenbühl, Stephan and Pichler, Werner J.. (2017) Medikamentöse Hepatopathien - Drug-induced liver injury. Therapeutische Umschau, 74 (3). pp. 123-130.

Drago, Sara and Imboden, Roger and Schlatter, Philipp and Buylaert, Mirabel and Krähenbühl, Stephan and Drewe, Juergen. (2017) Pharmacokinetics of Transdermal Etofenamate and Diclofenac in Healthy Volunteers. Basic and Clinical Pharmacology and Toxicology, 121 (5). pp. 423-429.

Parra-Guillen, Zinnia P. and Berger, Peter B. and Haschke, Manuel and Donzelli, Massimiliano and Winogradova, Daria and Pfister, Bogumila and Früh, Martin and Gillessen, Silke and Krähenbühl, Stephan and Kloft, Charlotte and Joerger, Markus. (2017) Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment. Basic and Clinical Pharmacology and Toxicology, 121 (4). pp. 309-315.

Grünig, David and Felser, Andrea and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells. Toxicology in Vitro, 42. pp. 337-347.

Brueckner, David and Roesti, David and Zuber, Ulrich and Sacher, Meik and Duncan, Derek and Krähenbühl, Stephan and Braissant, Olivier. (2017) Tunable diode laser absorption spectroscopy as method of choice for non-invasive and automated detection of microbial growth in media fills. Talanta, 167. pp. 21-29.

April 2016

Bloechliger, Marlene and Ceschi, Alessandro and Rüegg, Stephan and Kupferschmidt, Hugo and Krähenbühl, Stephan and Jick, Susan S. and Meier, Christoph R. and Bodmer, Michael. (2016) Risk of Seizures Associated with Antidepressant Use in Patients with Depressive Disorder: Follow-up Study with a Nested Case-Control Analysis Using the Clinical Practice Research Datalink. Drug Safety , 39 (4). pp. 307-321.

2016

Camblin, Marine and Berger, Benjamin and Haschke, Manuel and Krähenbühl, Stephan and Huwyler, Jörg and Puchkov, Maxim. (2016) CombiCap: A novel drug formulation for the basel phenotyping cocktail. International Journal of Pharmaceutics, 512 (1). pp. 253-261.

Mancuso, Riccardo V. and Welzenbach, Karl and Steinberger, Peter and Krähenbühl, Stephan and Weitz-Schmidt, Gabriele. (2016) Downstream effect profiles discern different mechanisms of integrin αLβ2 inhibition. Biochemical Pharmacology, 119. pp. 42-55.

Novakova, Katerina and Kummer, Oliver and Bouitbir, Jamal and Stoffel, Sonja D. and Hoerler-Koerner, Ulrike and Bodmer, Michael and Roberts, Paul and Urwyler, Albert and Ehrsam, Rolf and Krähenbühl, Stephan. (2016) Effect of l-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians. European Journal of Nutrition, 55 (1). pp. 207-217.

Bouitbir, Jamal and Haegler, Patrizia and Singh, François and Joerin, Lorenz and Felser, Andrea and Duthaler, Urs and Krähenbühl, Stephan. (2016) Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency. Frontiers in Physiology, 7. p. 345.

Kummer, Oliver and Hammann, Felix and Haschke, Manuel and Krähenbühl, Stephan. (2016) Reduction of hyperbilirubinemia with hypericum extract (St. John's Wort) in a patient with Crigler-Najjar syndrome type II. British Journal of Clinical Pharmacology, 81 (5). pp. 1002-1004.

Vogel, Marc and Bucher, Patricia and Strasser, Johannes and Liechti, Matthias E. and Krähenbühl, Stephan and Dürsteler, Kenneth M.. (2016) Similar and Different? Subjective Effects of Methylphenidate and Cocaine in Opioid-Maintained Patients. Journal of Psychoactive Drugs , 48 (2). pp. 93-100.

Bonifacio, Annalisa and Mullen, Peter J. and Mityko, Ileana Scurtu and Navegantes, Luiz C. and Bouitbir, Jamal and Krähenbühl, Stephan. (2016) Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo. Archives of Toxicology, 90 (1). pp. 203-215.

2 October 2015

Haegler, Patrizia and Grünig, David and Berger, Benjamin and Krähenbühl, Stephan and Bouitbir, Jamal. (2015) Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: a cell model for idiosyncratic toxicity. Toxicology, 336. pp. 48-58.

1 August 2015

Roberts, Paul A. and Bouitbir, Jamal and Bonifacio, Annalisa and Singh, François and Kaufmann, Priska and Urwyler, Albert and Krähenbühl, Stephan. (2015) Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiency. American Journal of Physiology. Endocrinology and Metabolism, 309 (3). E265-E274.

August 2015

Liakoni, Evangelia and Rätz Bravo, Alexandra E. and Krähenbühl, Stephan. (2015) Hepatotoxicity of New Oral Anticoagulants (NOACs). Drug safety, 38 (8). pp. 711-720.

Bonifacio, Annalisa and Sanvee, Gerda M. and Bouitbir, Jamal and Krähenbühl, Stephan. (2015) The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity. Biochimica et biophysica acta. Molecular cell research, 1853 (8). pp. 1841-1849.

28 May 2015

Ceschi, Alessandro and Heistermann, Elja and Gros, Sonja and Reichert, Cornelia and Kupferschmidt, Hugo and Banner, Nicholas R. and Krähenbühl, Stephan and Taegtmeyer, Anne B.. (2015) Acute sirolimus overdose: a multicenter case series. PLoS ONE, 10 (5). e0128033.

March 2015

Seeland, Swen and Kettiger, Helene and Murphy, Mark and Treiber, Alexander and Giller, Jasmin and Kiss, Andrea and Sube, Romain and Krähenbühl, Stephan and Hafner, Mathias and Huwyler, Jörg. (2015) ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacology Research & Perspecitves, 3 (2). e00123.

Sidharta, Patricia N. and Krähenbühl, Stephan and Dingemanse, Jasper. (2015) Pharmacokinetic and pharmacodynamic evaluation of macitentan , a novel endothelin receptor antagonist for the treatment of pulmonary arterial hypertension. Expert opinion on drug metabolism & toxicology, 11 (3). pp. 437-449.

February 2015

Blaser, Lea S. and Tramonti, Alexandra and Egger, Pascal and Haschke, Manuel and Krähenbühl, Stephan and Rätz Bravo, Alexandra E.. (2015) Hematological safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports. European journal of clinical pharmacology, 71 (2). pp. 209-217.

2015

Welzenbach, Karl and Mancuso, Riccardo V. and Krähenbühl, Stephan and Weitz-Schmidt, Gabriele. (2015) A novel multi-parameter assay to dissect the pharmacological effects of different modes of integrin αLβ2 inhibition in whole blood. British Journal of Pharmacology, 172 (20). pp. 4875-4887.

Singh, François and Charles, Anne-Laure and Schlagowski, Anna-Isabel and Bouitbir, Jamal and Bonifacio, Annalisa and Piquard, François and Krähenbühl, Stephan and Geny, Bernard and Zoll, Joffrey. (2015) Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis. Biochimica et biophysica acta. Molecular cell research, 1853 (7). pp. 1574-1585.

2014

Taegtmeyer, Anne B. and Haschke, Manuel and Tchambaz, Lydia and Buylaert, Mirabel and Tschöpl, Martin and Beuers, Ulrich and Drewe, Jürgen and Krähenbühl, Stephan. (2014) A study of the relationship between serum bile acids and propranolol pharmacokinetics and pharmacodynamics in patients with liver cirrhosis and in healthy controls. PLoS ONE, Vol. 9, H. 6 , e97885.

Ceschi, Alessandro and Gregoriano, Claudia and Rauber-Lüthy, Christine and Kupferschmidt, Hugo and Banner, Nicholas R. and Krähenbühl, Stephan and Taegtmeyer, Anne B.. (2014) Acute mycophenolate overdose : case series and systematic literature analysis. Expert opinion on drug safety, Vol. 13, H. 5. pp. 525-534.

Gregoriano, Claudia and Ceschi, Alessandro and Rauber-Lüthy, Christine and Kupferschmidt, Hugo and Banner, Nicholas R. and Krähenbühl, Stephan and Taegtmeyer, Anne B.. (2014) Acute thiopurine overdose : analysis of reports to a National Poison Centre 1995-2013. PLoS ONE, Vol. 9, H. 1 , e86390.

Morand, Réjane and Bouitbir, Jamal and Felser, Andrea and Hench, Jürgen and Handschin, Christoph and Frank, Stephan and Krähenbühl, Stephan. (2014) Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. European journal of nutrition, 53 (6). pp. 1313-1325.

Felser, Andrea and Stoller, Andrea and Morand, Réjane and Schnell, Dominik and Donzelli, Massimiliano and Terracciano, Luigi and Bouitbir, Jamal and Krähenbühl, Stephan. (2014) Hepatic toxicity of dronedarone in mice: role of mitochondrial β-oxidation. Toxicology, 323. pp. 1-9.

Felser, Andrea and Lindinger, Peter W. and Schnell, Dominik and Kratschmar, Denise V. and Odermatt, Alex and Mies, Suzette and Jenö, Paul and Krähenbühl, Stephan. (2014) Hepatocellular toxicity of benzbromarone : Effects on mitochondrial function and structure. Toxicology, Vol. 324. pp. 136-146.

Detampel, Pascal and Witzigmann, Dominik and Krähenbühl, Stephan and Huwyler, Jörg. (2014) Hepatocyte targeting using pegylated asialofetuin-conjugated liposomes. Journal of drug targeting, Vol. 22, No. 3. pp. 232-241.

Liakoni, Evangelia and Rätz Bravo, Alexandra E. and Terracciano, Luigi and Heim, Markus and Krähenbühl, Stephan. (2014) Symptomatic hepatocellular liver injury with hyperbilirubinemia in two patients treated with rivaroxaban. JAMA internal medicine, Vol. 174, H. 10. pp. 1683-1686.

Wuillemin, Natascha and Terracciano, Luigi and Beltraminelli, Helmut and Schlapbach, Christoph and Fontana, Stefano and Krähenbühl, Stephan and Pichler, Werner J. and Yerly, Daniel. (2014) T cells infiltrate the liver and kill hepatocytes in HLA-B(∗)57:01-associated floxacillin-induced liver injury. American journal of pathology, Vol. 184, no. 6. pp. 1677-1682.

Donzelli, Massimiliano and Derungs, Adrian and Serratore, Maria-Giovanna and Noppen, Christoph and Nezic, Lana and Krähenbühl, Stephan and Haschke, Manuel. (2014) The Basel Cocktail for Simultaneous Phenotyping of Human Cytochrome P450 Isoforms in Plasma, Saliva and Dried Blood Spots. Clinical pharmacokinetics, Vol. 53, H. 3. pp. 271-282.

Nezic, Lana and Derungs, Adrian and Bruggisser, Marcel and Tschudin-Sutter, Sarah and Krähenbühl, Stephan and Haschke, Manuel. (2014) Therapeutic drug monitoring of once daily aminoglycoside dosing : comparison of two methods and investigation of the optimal blood sampling strategy. European journal of clinical pharmacology, Vol. 70, H. 7. pp. 829-837.

2013

Franz, Carmen C. and Hildbrand, Carole and Born, Christa and Egger, Sabin and Rätz Bravo, Alexandra E. and Krähenbühl, Stephan. (2013) Dose adjustment in patients with liver cirrhosis : impact on adverse drug reactions and hospitalizations. European journal of clinical pharmacology, Vol. 69, H. 8. pp. 1565-1573.

Wuillemin, Natascha and Adam, Jacqueline and Fontana, Stefano and Krähenbühl, Stephan and Pichler, Werner J. and Yerly, Daniel. (2013) HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin. Journal of immunology, Vol. 190, H. 10. pp. 4956-4964.

Zahno, Anja and Bouitbir, Jamal and Maseneni, Swarma and Lindinger, Peter W. and Brecht, Karin and Krähenbühl, Stephan. (2013) Hepatocellular toxicity of clopidogrel: Mechanisms and risk factors. Free radical biology and medicine, 65. pp. 208-216.

Krähenbühl, Stephan. (2013) Leicht erhöhte Transaminasen. Therapeutische Umschau, Vol. 70, H. 5. pp. 284-288.

Felser, Andrea and Blum, Kim and Lindinger, Peter W. and Bouitbir, Jamal and Krähenbühl, Stephan. (2013) Mechanisms of hepatocellular toxicity associated with dronedarone--a comparison to amiodarone. Toxicological sciences, 131 (2). pp. 480-490.

Haschke, Manuel and Schuster, Manfred and Poglitsch, Marko and Loibner, Hans and Salzberg, Marc and Bruggisser, Marcel and Penninger, Joseph and Krähenbühl, Stephan. (2013) Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clinical pharmacokinetics, Vol. 52, H. 9. pp. 783-792.

Morand, Réjane and Donzelli, Massimiliano and Haschke, Manuel and Krähenbühl, Stephan. (2013) Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. Analytical and bioanalytical chemistry, Vol. 405, H. 27. pp. 8829-8836.

Caduff Good, Angela and Nobel, Daniel and Krähenbühl, Stephan and Geisen, Christof and Henz, Samuel. (2013) Randomised trial of a clinical dosing algorithm to start anticoagulation with phenprocoumon. Swiss medical weekly, Vol. 143 , w13709.

Giger-Pabst, Urs and Lange, Jochen and Maurer, Christoph and Bucher, Carine and Schreiber, Vital and Schlumpf, Rolf and Kocher, Thomas and Schweizer, Walter and Krähenbühl, Stephan and Krähenbühl, Lukas. (2013) Short-term preoperative supplementation of an immunoenriched diet does not improve clinical outcome in well-nourished patients undergoing abdominal cancer surgery. Nutrition, Vol. 29, H. 5. pp. 724-729.

Maseneni, Swarna and Donzelli, Massimiliano and Brecht, Karin and Krähenbühl, Stephan. (2013) Toxicity of thienopyridines on human neutrophil granulocytes and lymphocytes. Toxicology, 308. pp. 11-19.

2012

See, Hong Heng and Schmidt-Marzinkowski, Julia and Pormsila, Worapan and Morand, Réjane and Krähenbühl, Stephan and Hauser, Peter C.. (2012) Determination of creatine and phosphocreatine in muscle biopsy samples by capillary electrophoresis with contactless conductivity detection. Analytica Chimica Acta, 727. pp. 78-82.

Detampel, Pascal and Beck, Mareike and Krähenbühl, Stephan and Huwyler, Jörg. (2012) Drug interaction potential of resveratrol. Drug metabolism reviews, Vol. 44, H. 3. pp. 253-265.

Franz, Carmen C. and Egger, Sabin and Born, Christa and Rätz Bravo, Alexandra E. and Krähenbühl, Stephan. (2012) Potential drug-drug interactions and adverse drug reactions in patients with liver cirrhosis. European journal of clinical pharmacology, Vol. 68, H. 2. pp. 179-188.

Henkel, Verena and Casaulta, Flurina and Seemüller, Florian and Krähenbühl, Stephan and Obermeier, Michael and Hüsler, Jürg and Möller, Hans-Jürgen. (2012) Study design features affecting outcome in antidepressant trials. Journal of affective disorders, Vol. 141, H. 2-3. pp. 160-167.

Maseneni, Swarna and Donzelli, Massimiliano and Taegtmeyer, A. B. and Brecht, Karin and Krähenbühl, Stephan. (2012) Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites. Toxicology, 299 (2-3). pp. 139-145.

2011

Halter, Joerg and Schüpbach, W. M. Michael and Casali, Carlo and Elhasid, Ronit and Fay, K. and Hammans, S. and Illa, I. and Kappeler, Liliane and Krähenbühl, Stephan and Lehmann, T. and Mandel, H. and Marti, Ramon and Mattle, Heinrich P. and Orchard, Kim and Savage, David and Sue, Carolyn M. and Valcarcel, David and Gratwohl, Alois and Hirano, M.. (2011) Allogeneic hematopoietic SCT as treatment option for patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): a consensus conference proposal for a standardized approach. Bone marrow transplantation, 46 (3). pp. 330-337.

Pormsila, Worapan and Morand, Réjane and Krähenbühl, Stephan and Hauser, Peter C.. (2011) Capillary electrophoresis with contactless conductivity detection for the determination of carnitine and acylcarnitines in clinical samples. Journal of Chromatography B, 879 (13-14). pp. 921-926.

Kummer, Oliver and Hammann, Felix and Moser, Claudine and Schaller, Olivier and Drewe, Jürgen and Krähenbühl, Stephan. (2011) Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. European journal of clinical pharmacology, Vol. 67, H. 1. pp. 63-71.

Hoch, Matthias and Hoever, Petra and Haschke, Manuel and Krähenbühl, Stephan and Dingemanse, Jasper. (2011) Food effect and biocomparison of two formulations of the dual orexin receptor antagonist almorexant in healthy male subjects. The journal of clinical pharmacology, Vol. 51, H. 7. pp. 1116-1121.

Pormsila, Worapan and Morand, Réjane and Krähenbühl, Stephan and Hauser, Peter C.. (2011) Quantification of plasma lactate concentrations using capillary electrophoresis with contactless conductivity detection. Electrophoresis, 32 (8). pp. 884-889.

Mullen, Peter J. and Zahno, Anja and Lindinger, Peter and Maseneni, Swarma and Felser, Andrea and Krähenbühl, Stephan and Brecht, Karin. (2011) Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt. Biochimica et biophysica acta, Vol. 1813, H. 12. pp. 2079-2087.

Derungs, Adrian and Schietzel, Simeon and Meyer, Markus R. and Maurer, Hans H. and Krähenbühl, Stephan and Liechti, Matthias E.. (2011) Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone (naphthylpyrovalerone). Clinical toxicology, 49 (7). pp. 691-693.

Zahno, Anja and Brecht, Karin and Morand, Réjane and Maseneni, Swarna and Török, Michael and Lindinger, Peter W. and Krähenbühl, Stephan. (2011) The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells. Biochemical pharmacology, Vol. 81, Issue 3. pp. 432-441.

2010

Mullen, Peter James and Lüscher, Barbara and Scharnagl, Hubert and Krähenbühl, Stephan and Brecht, Karin. (2010) Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy. Biochemical pharmacology, 79 (8). pp. 1200-1209.

Zahno, Anja and Brecht, Karin and Bodmer, Michael and Bur, Daniel and Tsakiris, Dimitrios A. and Krähenbühl, Stephan. (2010) Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro. British journal of pharmacology, 161 (2). pp. 393-404.

Brauchli, Yolanda B. and Wais, Thomas and Gratwohl, Alois and Heim, Dominik and Schipf, Alexander and Diebold, Joachim and Krähenbühl, Stephan. (2010) Fatal myocardial infarction during nilotinib treatment in a 60-year-old male patient. Acta oncologica, Vol. 49, no. 4. pp. 523-525.

Bodmer, Michael and Meier, Christian and Krähenbühl, Stephan and Jick, Susan S. and Meier, Christoph R.. (2010) Long-term metformin use is associated with decreased risk of breast cancer. Diabetes care, Vol. 33, H. 6. pp. 1304-1308.

Krämer, Isabel and Rauber-Lüthy, Christine and Kupferschmidt, Hugo and Krähenbühl, Stephan and Ceschi, Alessandro. (2010) Minimal dose for severe poisoning and influencing factors in acute human clozapine intoxication : a 13-year retrospective study. Clinical neuropharmacology, Vol. 33, H. 5. pp. 230-234.

Haschke, Manuel and Suter, Katja and Hofmann, Sarah and Witschi, Robert and Fröhlich, Johannes and Imanidis, Georgios and Drewe, Jürgen and Briellmann, Thomas A. and Dussy, Franz E. and Krähenbühl, Stephan and Surber, Christian. (2010) Pharmacokinetics and pharmacodynamics of nasally delivered midazolam. British journal of clinical pharmacology, Vol. 69, H. 6. pp. 607-616.

Poller, Birk and Drewe, Jürgen and Krähenbühl, Stephan and Huwyler, Jörg and Gutmann, Heike. (2010) Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier. Cellular and Molecular Neurobiology, Vol. 30, No. 1. pp. 63-70.

Schürch, Regula and Todesco, Liliane and Novakova, Katarina and Mevissen, Meike and Stieger, Bruno and Krähenbühl, Stephan. (2010) The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats. European journal of pharmacology, Vol. 635, H. 1-3. pp. 171-176.

2009

Kummer, Oliver and Haschke, Manuel and Hammann, Felix and Bodmer, Michael and Bruderer, Shirin and Regnault, Yann and Dingemanse, Jasper and Krähenbühl, Stephan. (2009) Comparison of the dissolution and pharmacokinetic profiles of two galenical formulations of the endothelin receptor antagonist macitentan. European journal of pharmaceutical sciences, Vol. 38, H. 4. pp. 384-388.

Rätz Bravo, Alexandra E. and Hofer, Silvia and Krähenbühl, Stephan and Ludwig, Christian. (2009) Fatal drug-drug interaction of brivudine and capecitabine. Acta oncologica, Vol. 48, no. 4. pp. 631-633.

Todesco, Liliane and Bodmer, Michael and Vonwil, Karin and Häussinger, Daniel and Krähenbühl, Stephan. (2009) Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2. Chemico-Biological Interactions , 180 (3). pp. 472-477.

Schlatter, Chantal and Egger, Sabin S. and Tchambaz, Lydia and Krähenbühl, Stephan. (2009) Pharmacokinetic changes of psychotropic drugs in patients with liver disease : implications for dose adaptation. Drug safety, Vol. 32, no. 7. pp. 561-578.

Bodmer, Michael and Brauchli, Yolanda B. and Krähenbühl, Stephan and Jick, Susan S. and Meier, Christoph R.. (2009) Statin use and risk of gallstone disease followed by cholecystectomy. JAMA : the journal of the American Medical Association, Vol. 302, H. 18. pp. 2001-2007.

2008

Brauchli, Yolanda B. and Gittermann, Matthias and Michot, Marc and Krähenbühl, Stephan and Gnehm, Hanspeter E.. (2008) A fatal tick bite occurring during the course of tick-borne encephalitis vaccination. Pediatric infectious disease journal, Vol. 27. pp. 363-365.

Botomino, Andrea and Bruppacher, Rudolf and Krähenbühl, Stephan and Hersberger, Kurt E.. (2008) Change of body weight and lifestyle of persons at risk for diabetes after screening and counselling in pharmacies. Pharmacy world & science, Vol. 30, H. 3. pp. 222-226.

Knapp, Andrea Caroline and Todesco, Liliane and Torok, Michael and Beier, Konstantin and Krähenbühl, Stephan. (2008) Effect of carnitine deprivation on carnitine homeostasis and energy metabolism in mice with systemic carnitine deficiency. Annals of nutrition and metabolism, Vol. 52, No. 2. pp. 136-144.

Vonbach, Priska and Dubied, André and Krähenbühl, Stephan and Beer, Jürg H.. (2008) Evaluation of frequently used drug interaction screening programs. Pharmacy world & science, Vol. 30, H. 4. pp. 367-374.

Lüde, Saskia and Török, Michael and Dieterle, Sandy and Jäggi, René and Büter, Karin Berger and Krähenbühl, Stephan. (2008) Hepatocellular toxicity of kava leaf and root extracts. Phytomedicine, Vol. 15, H. 1-2. pp. 120-131.

Waldhauser, Katri M. and Brecht, Karin and Hebeisen, S. and Ha, H. R. and Konrad, D. and Bur, Daniel and Krähenbühl, Stephan. (2008) Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues. British journal of pharmacology, 155 (4). pp. 585-595.

Aschmann, Yvonne Zysset and Kummer, Oliver and Linka, André and Wenk, Markus and Azzola, Andrea and Bodmer, Michael and Krähenbühl, Stephan and Haschke, Manuel. (2008) Pharmacokinetics and pharmacodynamics of sildenafil in a patient treated with human immunodeficiency virus protease inhibitors. Therapeutic drug monitoring, Vol. 30, H. 1. pp. 130-134.

Link, Bettina and Haschke, Manuel and Grignaschi, Nathalie and Bodmer, Michael and Aschmann, Yvonne Zysset and Wenk, Markus and Krähenbühl, Stephan. (2008) Pharmacokinetics of intravenous and oral midazolam in plasma and saliva in humans: usefulness of saliva as matrix for CYP3A phenotyping. British journal of clinical pharmacology, 66 (4). pp. 473-484.

Vonbach, Priska and Dubied, André and Krähenbühl, Stephan and Beer, Jürg H.. (2008) Prevalence of drug-drug interactions at hospital entry and during hospital stay of patients in internal medicine. European journal of internal medicine, Vol. 19, H. 6. pp. 413-420.

Brauchli, Yolanda B. and Scholer, André and Schwietert, Martin and Krähenbühl, Stephan. (2008) Undetectable phenytoin serum levels by an automated particle-enhanced turbidimetric inhibition immunoassay in a patient with monoclonal IgM lambda. Clinica chimica acta, Vol. 389, H. 1-2. pp. 174-176.

2006

Kaufmann, Priska and Török, Michael and Zahno, Anja and Waldhauser, Katri and Brecht, Karin and Krähenbühl, Stephan. (2006) Toxicity of statins on rat skeletal muscle mitochondria. Cellular and Molecular Life Sciences, 63 (19-20). pp. 2415-2425.

2005

Schnyder, Anita and Krähenbühl, Stephan and Drewe, Jürgen and Huwyler, Jörg. (2005) Targeting of daunomycin using biotinylated immunoliposomes: Pharmacokinetics, tissue distribution and in vitro pharmacological effects. Journal of Drug Targeting, 13 (5). pp. 325-335.