Items where Author is "Gibhard, L."

2022

Mambwe, D. and Korkor, CM. and Mabhula, A. and Ngqumba, Z. and Cloete, C. and Kumar, M. and Barros, PL. and Leshabane, M. and Coertzen, D. and Taylor, D. and Gibhard, L. and Njoroge, M. and Lawrence, N. and Reader, J. and Moreira, DR. and Birkholtz, LM. and Wittlin, S. and Egan, TJ. and Chibale, K.. (2022) Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and; in vivo; efficacy in a; Plasmodium berghei; mouse malaria infection model. Journal of medicinal chemistry, 65 (24). pp. 16695-16715.

2021

Dziwornu, G. A. and Coertzen, D. and Leshabane, M. and Korkor, C. M. and Cloete, C. K. and Njoroge, M. and Gibhard, L. and Lawrence, N. and Reader, J. and van der Watt, M. and Wittlin, S. and Birkholtz, L. M. and Chibale, K.. (2021) Antimalarial benzimidazole derivatives incorporating phenolic mannich base side chains inhibit microtubule and hemozoin formation: structure-activity relationship and in vivo oral efficacy studies. Journal of medicinal chemistry, 64 (8). pp. 5198-5215.

Le Manach, C. and Dam, J. and Woodland, J. G. and Kaur, G. and Khonde, L. P. and Brunschwig, C. and Njoroge, M. and Wicht, K. J. and Horatscheck, A. and Paquet, T. and Boyle, G. A. and Gibhard, L. and Taylor, D. and Lawrence, N. and Yeo, T. and Mok, S. and Eastman, R. T. and Dorjsuren, D. and Talley, D. C. and Guo, H. and Simeonov, A. and Reader, J. and van der Watt, M. and Erlank, E. and Venter, N. and Zawada, J. W. and Aswat, A. and Nardini, L. and Coetzer, T. L. and Lauterbach, S. B. and Bezuidenhout, B. C. and Theron, A. and Mancama, D. and Koekemoer, L. L. and Birkholtz, L. M. and Wittlin, S. and Delves, M. and Ottilie, S. and Winzeler, E. A. and von Geldern, T. W. and Smith, D. and Fidock, D. A. and Street, L. J. and Basarab, G. S. and Duffy, J. and Chibale, K.. (2021) Identification and profiling of a novel diazaspiro[3.4]octane chemical series active against multiple stages of the human malaria parasite Plasmodium falciparum and optimization efforts. Journal of medicinal chemistry, 64 (4). pp. 2291-2309.

2020

Horatscheck, A. and Andrijevic, A. and Nchinda, A. T. and Le Manach, C. and Paquet, T. and Khonde, L. P. and Dam, J. and Pawar, K. and Taylor, D. and Lawrence, N. and Brunschwig, C. and Gibhard, L. and Njoroge, M. and Reader, J. and van der Watt, M. and Wicht, K. and de Sousa, A. C. C. and Okombo, J. and Maepa, K. and Egan, T. J. and Birkholtz, L. M. and Basarab, G. S. and Wittlin, S. and Fish, P. V. and Street, L. J. and Duffy, J. and Chibale, K.. (2020) Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast-killing kinetics and in vivo efficacy in the Plasmodium falciparum NSG mouse model. Journal of medicinal chemistry, 63 (21). pp. 13013-13030.