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Items where Author is "Brunschwig, Christel"

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Group by: Date | Item Type | Refereed
Jump to: 2019 | 2018 | 2017 | 2015
Number of items: 8.

2019

Okombo, John and Brunschwig, Christel and Singh, Kawaljit and Dziwornu, Godwin Akpeko and Barnard, Linley and Njoroge, Mathew and Wittlin, Sergio and Chibale, Kelly. (2019) Antimalarial pyrido[1,2-a]benzimidazole derivatives with mannich base side chains: synthesis, pharmacological evaluation and reactive metabolite trapping studies. ACS infectious diseases, 5 (3). pp. 372-384.

2018

Le Manach, Claire and Paquet, Tanya and Wicht, Kathryn and Nchinda, Aloysius T. and Brunschwig, Christel and Njoroge, Mathew and Gibhard, Liezl and Taylor, Dale and Lawrence, Nina and Wittlin, Sergio and Eyermann, Charles J. and Basarab, Gregory S. and Duffy, James and Fish, Paul V. and Street, Leslie J. and Chibale, Kelly. (2018) Antimalarial lead-optimization studies on a 2,6-imidazopyridine series within a constrained chemical space to circumvent atypical dose-response curves against multidrug resistant parasite strains. Journal of medicinal chemistry, 61 (20). pp. 9371-9385.

Nchinda, Aloysius T. and Le Manach, Claire and Paquet, Tanya and Gonzàlez Cabrera, Diego and Wicht, Kathryn J. and Brunschwig, Christel and Njoroge, Mathew and Abay, Efrem and Taylor, Dale and Lawrence, Nina and Wittlin, Sergio and Jiménez-Díaz, María-Belén and Santos Martínez, María and Ferrer, Santiago and Angulo-Barturen, Iñigo and Lafuente-Monasterio, Maria Jose and Duffy, James and Burrows, Jeremy and Street, Leslie J. and Chibale, Kelly. (2018) Identification of fast-acting 2,6-disubstituted imidazopyridines that are efficacious in the In Vivo humanized Plasmodium falciparum nodscidil2rgamma (null) mouse model of malaria. Journal of medicinal chemistry, 61 (9). pp. 4213-4227.

Gibhard, Liezl and Njoroge, Mathew and Paquet, Tanya and Brunschwig, Christel and Taylor, Dale and Lawrence, Nina and Abay, Efrem and Wittlin, Sergio and Wiesner, Lubbe and Street, Leslie J. and Chibale, Kelly and Basarab, Gregory S.. (2018) Investigating sulfoxide to sulfone conversion as a prodrug strategy for a PI4K inhibitor in a humanized mouse model of malaria. Antimicrobial agents and chemotherapy, 62 (12). e00261-18.

Brunschwig, Christel and Lawrence, Nina and Taylor, Dale and Abay, Efrem and Njoroge, Mathew and Basarab, Gregory S. and Le Manach, Claire and Paquet, Tanya and Cabrera, Diego Gonzàlez and Nchinda, Aloysius T. and de Kock, Carmen and Wiesner, Lubbe and Denti, Paolo and Waterson, David and Blasco, Benjamin and Leroy, Didier and Witty, Michael J. and Donini, Cristina and Duffy, James and Wittlin, Sergio and White, Karen L. and Charman, Susan A. and Jiménez-Díaz, Maria Belén and Angulo-Barturen, Iñigo and Herreros, Esperanza and Gamo, Francisco Javier and Rochford, Rosemary and Mancama, Dalu and Coetzer, Theresa L. and van der Watt, Mariëtte E. and Reader, Janette and Birkholtz, Lyn-Marie and Marsh, Kennan C. and Solapure, Suresh M. and Burke, John E. and McPhail, Jacob A. and Vanaerschot, Manu and Fidock, David A. and Fish, Paul V. and Siegl, Peter and Smith, Dennis A. and Wirjanata, Grennady and Noviyanti, Rintis and Price, Ric N. and Marfurt, Jutta and Silue, Kigbafori D. and Street, Leslie J. and Chibale, Kelly. (2018) UCT943, a next generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria. Antimicrobial agents and chemotherapy, 62 (9). e00012-e00018.

2017

Singh, Kawaljit and Okombo, John and Brunschwig, Christel and Ndubi, Ferdinand and Barnard, Linley and Wilkinson, Chad and Njogu, Peter M. and Njoroge, Mathew and Laing, Lizahn and Machado, Marta and Prudêncio, Miguel and Reader, Janette and Botha, Mariette and Nondaba, Sindisiwe and Birkholtz, Lyn-Marie and Lauterbach, Sonja and Churchyard, Alisje and Coetzer, Theresa L. and Burrows, Jeremy N. and Yeates, Clive and Denti, Paolo and Wiesner, Lubbe and Egan, Timothy J. and Wittlin, Sergio and Chibale, Kelly. (2017) Antimalarial pyrido[1,2-a]benzimidazoles : lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and in vivo oral efficacy in a mouse model. Journal of medicinal chemistry, 60 (4). pp. 1432-1448.

Okombo, John and Singh, Kawaljit and Mayoka, Godfrey and Ndubi, Ferdinand and Barnard, Linley and Njogu, Peter M. and Njoroge, Mathew and Gibhard, Liezl and Brunschwig, Christel and Vargas, Mireille and Keiser, Jennifer and Egan, Timothy J. and Chibale, Kelly. (2017) Antischistosomal activity of pyrido[1,2-a]benzimidazole derivatives and correlation with inhibition of beta-hematin formation. ACS Infectious Diseases, 3 (6). pp. 411-420.

2015

Le Manach, Claire and Paquet, Tanya and Brunschwig, Christel and Njoroge, Mathew and Han, Ze and Gonzàlez Cabrera, Diego and Bashyam, Sridevi and Dhinakaran, Rajkumar and Taylor, Dale and Reader, Janette and Botha, Mariette and Churchyard, Alisje and Lauterbach, Sonja and Coetzer, Theresa L. and Birkholtz, Lyn-Marie and Meister, Stephan and Winzeler, Elizabeth A. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Jiménez-Díaz, María-Belén and Santos Martínez, María and Ferrer, Santiago and Angulo-Barturen, Iñigo and Street, Leslie J. and Chibale, Kelly. (2015) A novel pyrazolopyridine with in vivo activity in Plasmodium berghei- and Plasmodium falciparum-infected mouse models from structure-activity relationship studies around the core of recently identified antimalarial imidazopyridazines. Journal of medicinal chemistry, 58 (21). pp. 8713-8722.

This list was generated on Tue Sep 22 13:58:28 2020 CEST.