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Items where Author is "Brun, R."

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Number of items: 185.

2019

Mufusama, J. P. and Feineis, D. and Mudodo, V. and Kaiser, M. and Brun, R. and Bringmann, G.. (2019) Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,80'-coupled monomeric alkaloids, ikelacongolines A-D, from a Congolese Ancistrocladus liana. RSC advances, 9 (21). pp. 12034-12046.

2018

Schies, C. and Seupel, R. and Feineis, D. and Gehrold, A. and Schraut, M. and Kaiser, M. and Brun, R. and Bringmann, G.. (2018) Biomimetic total synthesis of mbandakamine A and further antiplasmodial naphthylisoquinoline dimers. ChemistrySelect, 3. pp. 940-945.

Nefertiti, A. S. G. and Batista, M. M. and Da Silva, P. B. and Batista, D. G. J. and Da Silva, C. F. and Peres, R. B. and Torres-Santos, E. C. and Cunha-Junior, E. F. and Holt, E. and Boykin, D. W. and Brun, R. and Wenzler, T. and Soeiro, M. N. C.. (2018) In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines. Antimicrobial Agents and Chemotherapy, 62 (2). e01936-17.

Gysin, M. and Braissant, O. and Gillingwater, K. and Brun, R. and Mäser, P. and Wenzler, T.. (2018) Isothermal microcalorimetry - a quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time. International journal for parasitology. Drugs and drug resistance, 8 (2). pp. 159-164.

Lombe, B. K. and Feineis, D. and Mudogo, V. and Brun, R. and Awale, S. and Bringmann, G.. (2018) Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells. RSC advances, 8 (10). pp. 5243-5254.

Nefertiti, A. S. G. and Batista, M. M. and Da Silva, P. B. and Batista, D. G. J. and Da Silva, C. F. and Peres, R. B. and Torres-Santos, E. C. and Cunha-Junior, E. F. and Holt, E. and Boykin, D. W. and Brun, R. and Wenzler, T. and Soeiro, M. N. C.. (2018) The trypanocidal effect of novel quinolines: in vitro and in vivo studies. Antimicrobial agents and chemotherapy, 62 (2). e01936-17.

2017

Greve, H. L. and Kaiser, M. and Brun, R. and Schmidt, Tj. (2017) Erratum: terpenoids from the oleo-gum-resin of boswellia serrata and their antiplasmodial effects in vitro. Planta medica, 83 (14-15). E4.

Farahat, A. A. and Kumar, A. and Say, M. and Wenzler, T. and Brun, R. and Paul, A. and Wilson, D. W. and Boykin, D. W.. (2017) Exploration of DAPI analogues : synthesis, antitrypanosomal activity, DNA binding and fluorescence properties. European journal of medicinal chemistry, 128. pp. 70-78.

Akama, T. and Zhang, Y. K. and Freund, Y. R. and Berry, P. and Lee, J. and Easom, E. E. and Jacobs, R. T. and Plattner, J. J. and Witty, M. J. and Peter, R. and Rowan, T. G. and Gillingwater, K. and Brun, R. and Nare, B. and Mercer, L. and Xu, M. and Wang, J. and Liang, H.. (2017) Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). Bioorganic and Medicinal Chemistry Letters, 28. pp. 6-10.

2016

Vanden Eynde, J. J. and Mayence, A. and Mottamal, M. and Bacchi, C. J. and Yarlett, N. and Kaiser, M. and Brun, R. and Huang, T. L.. (2016) Alkanediamide-linked bisbenzamidines are promising antiparasitic agents. Pharmaceuticals, 9 (2). pp. 1-11.

Vahermo, M. and Krogerus, S. and Nasereddin, A. and Kaiser, M. and Brun, R. and Jaffe, C. L. and Yli-Kauhaluoma, J. and Moreira, V. M.. (2016) Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania denovani and Trypanosoma cruzi. MedChemComm, 7 (3). pp. 457-463.

Faist, J. and Seebacher, W. and Saf, R. and Brun, R. and Kaiser, M. and Weis, R.. (2016) New derivatives of bicyclic diamines with antiprotozoal activity. Monatshefte für Chemie, 147 (2). pp. 369-381.

Wolkinger, V. and Ahmad, S. and Seebacher, W. and Faist, J. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2016) New diaryl-substituted azabicyclo[3.2.2]nonanes and their antiprotozoal potencies. Monatshefte für Chemie, 147 (10). pp. 1721-1735.

Tasdemir, D. and Sen, R. and Bergonzi, M. C. and Demirci, B. and Bilia, A. R. and Baser, K. H. C. and Brun, R. and Chatterjee, M.. (2016) Rapid chemical analysis and antiprotozoal effect of the solvent extracts and the essential oil of Artemisia indica. Planta medica, 81 (16). pp. 1547-1548.

2015

De Mieri, M. and Kaiser, M. and Brun, R. and Thormann, U. and Imanidis, G. and Hamburger, M.. (2015) Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin. Bioorganic & medicinal chemistry, 23 (7). pp. 1521-1529.

Seebacher, W. and Faist, J. and Belaj, F. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2015) Synthesis of new tetrahydropyridinylidene ammonium salts and their antprotozoal potency. Monatshefte für Chemie, 146 (8). pp. 1299-1308.

2014

Hanna, J. N. and Ntie-Kang, F. and Kaiser, M. and Brun, R. and Efange, S. M. N.. (2014) 1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials : synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation. RSC advances, Vol. 4, H. 44 ,22856-22865.

Weis, R. and Seebacher, W. and Brun, R. and Kaiser, M. and Saf, R. and Faist, J.. (2014) 4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity. Monatshefte für Chemie, Vol. 145, H. 2. pp. 311-317.

Usuki, T. and Sato, M. and Hara, S. and Yoshimoto, Y. and Kondo, R. and Zimmermann, S. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2014) Antitrypanosomal structure-activity-relationship study of semisynthetic cynaropicrin derivatives. Bioorganic and Medicinal Chemistry Letters, 24 (3). pp. 794-798.

Burri, C. and Chappuis, F. and Brun, R.. (2014) Human African trypanosomiasis. In: Manson's Tropical Diseases. - 23rd ed.. [Edinburgh], pp. 606-621.

Hata, Y. and de Mieri, M. and Ebrahimi, S. N. and Mokoka, T. and Fouche, G. and Kaiser, M. and Brun, R. and Potterat, O. and Hamburger, M.. (2014) Identification of two new phenanthrenones and a saponin as antiprotozoal constituents of Drypetes gerrardii. Phytochemistry letters, Vol. 10. pp. 133-140.

Hata, Y. and De Mieri, M. and Ebrahimi, S. N. and Mokoka, T. and Fouche, G. and Kaiser, M. and Brun, R. and Potterat, O. and Hamburger, M.. (2014) Identification of two new phenathrenones and a saponin as antiprotozoal constituents of Drypetes gerrardii. Phytochemistry letters, Vol. 10. pp. 133-140.

Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Belaj, F. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2014) Synthesis of antiprotozoal diamines by regioselective insertion of nitrogen into a bicyclic ring system. Monatshefte für Chemie, Vol. 145, H. 8. pp. 1319-1327.

2013

Malebo, H. M. and Wenzler, T. and Cal, M. and Swaleh, S. M. and Omolo, M. O. and Hassanali, A. and Sequin, U. and Häussinger, D. and Dalsgaard, P. and Hamburger, M. and Brun, R. and Ndiege, I. O.. (2013) Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae). BMC complementary and alternative medicine, Vol. 13 , 48.

Mokoka, Tsholofelo A. and Xolani, Peter K. and Zimmermann, S. and Hata, Y. and Adams, M. and Kaiser, M. and Moodley, N. and Maharaj, Y. and Koorbanally, Neil A. and Hamburger, M. and Brun, R. and Fouche, G.. (2013) Antiprotozoal Screening of 60 South African Plants, and the Identification of the Antitrypanosomal Germacranolides Schkuhrin I and II. Planta medica, Vol. 79, H. 14. pp. 1380-1384.

Obbo, C. J. D. and Makanga, B. and Mulholland, D. A. and Coombes, P. H. and Brun, R.. (2013) Antiprotozoal activity of Khaya anthotheca, (Welv.) C.D.C. A plant used by chimpanzees for self medication. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 147, H. 1. pp. 220-223.

Molette, J. and Routier, J. and Abla, N. and Besson, D. and Bombrun, A. and Brun, R. and Burt, H. and Georgi, K. and Kaiser, M. and Nwaka, S. and Muzerelle, M. and Scheer, A.. (2013) Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties. ACS medicinal chemistry letters, Vol. 4, H. 11. pp. 1037-1041.

Bringmann, G. and Zhang, G. and Büttner, T. and Bauckmann, G. and Kupfer, T. and Braunschweig, H. and Brun, R. and Mudogo, V.. (2013) Jozimine A2 : the first dimeric dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity. Chemistry : a European journal, Vol. 19, H. 3. pp. 916-923.

Friggeri, L. and Scipione, L. and Costi, R. and Kaiser, M. and Moraca, F. and Zamperini, C. and Botta, B. and Di Santo, R. and De Vita, D. and Brun, R. and Tortorella, S.. (2013) New promising compounds with in vitro nanomolar activity against Trypanosoma cruzi. ACS medicinal chemistry letters, Vol. 4, H. 6. pp. 538-541.

Hwang, J. Y. and Smithson, S. C. and Zhu, F. and Holbrook, G. and Connelly, M. C. and Kaiser, M. and Brun, R. and Guy, R. K.. (2013) Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for Human African Trypanosomiasis (HAT). Journal of medicinal chemistry, 56 (7). pp. 2850-2860.

Aureggi, V. and Ehmke, V. and Wieland, J. and Schweizer, W. B. and Bernet, B. and Bur, D. and Meyer, S. and Rottmann, M. and Freymond, C. and Brun, R. and Breit, B. and Diederich, F.. (2013) Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes. Chemistry : a European journal, Vol. 19, H. 1. pp. 155-164.

Brunner, R. and Ng, C. L. and Aissaoui, H. and Akabas, M. H. and Boss, C. and Brun, R. and Callaghan, P. S. and Corminboeuf, O. and Fidock, D. A. and Frame, I. J. and Heidmann, B. and Le Bihan, A. and Jeno, P. and Mattheis, C. and Moes, S. and Muller, I. B. and Paguio, M. and Roepe, P. D. and Siegrist, R. and Voss, Till S. and Welford, R. W. and Wittlin, S. and Binkert, C.. (2013) UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. Journal of biological chemistry, Vol. 288, H. 31. pp. 22576-22583.

2012

Gökbulut, A. and Kaiser, M. and Brun, R. and Sarer, E. and Schmidt, T. J.. (2012) 9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity. Planta medica, Vol. 78, H. 3. pp. 225-229.

Witschel, M. and Rottmann, M. and Kaiser, M. and Brun, R.. (2012) Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. PLoS neglected tropical diseases, Vol. 6, H. 10 , e1805.

Mäser, P. and Wittlin, S. and Rottmann, M. and Wenzler, T. and Kaiser, M. and Brun, R.. (2012) Antiparasitic agents : new drugs on the horizon. Current opinion in pharmacology, Vol. 12, H. 5. pp. 562-566.

Abiodun, O. O. and Gbotosho, G. O. and Ajaiyeoba, E. O. and Brun, R. and Oduola, A. M.. (2012) Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine. Parasitology research, Vol. 110, H. 2. pp. 521-526.

Lizzi, F. and Veronesi, G. and Belluti, F. and Bergamini, C. and Lopez-Sanchez, A. and Kaiser, M. and Brun, R. and Krauth-Siegel, R. L. and Hall, D. and Rivas, L. and Bolognesi, M. L.. (2012) Conjugation of quinones with natural polyamines : towards an expanded anti-trypanosomatid profile. Journal of medicinal chemistry, 55 (23). pp. 10490-10500.

Zimmermann, S. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2012) Cynaropicrin : the first natural product with in vivo activity against Trypanosoma bruce rhodesiense. Planta medica, Vol. 78, H. 6. pp. 553-556.

Carvalho, S. A. and Feitosa, L. O. and Soares, M. and Costa, T. E. and Henriques, M. G. and Salomao, K. and de Castro, S. L. and Kaiser, M. and Brun, R. and Wardell, J. L. and Wardell, S. M. and Trossini, G. H. and Andricopulo, A. D. and da Silva, E. F. and Fraga, C. A.. (2012) Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents. European journal of medicinal chemistry, 54. pp. 512-521.

Ahmad, S. and Weis, R. and Faist, J. and Wolkinger, V. and Saf, R. and Belaj, F. and Brun, R. and Kaiser, M. and Seebacher, W.. (2012) Diarylcyclohexanones : synthons for new bicyclic compounds. Monatshefte für Chemie, Vol. 143, H. 1. pp. 145-152.

Brun, R. and Blum, J.. (2012) Human African trypanosomiasis. Infectious disease clinics of North America, Vol. 26, H. 2. pp. 261-273.

Farimani, M. M. and Taheri, S. and Ebrahimi, S. N. and Bahadori, M. B. and Khavasi, H. R. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2012) Hydrangenone, a new Isoprenoid with an unprecedented skeleton from Salvia hydrangea. Organic Letters, 14 (1). pp. 166-169.

Mombelli, P. and Witschel, M. C. and van Zijl, A. W. and Geist, J. G. and Rottmann, M. and Freymond, C. and Röhl, F. and Kaiser, M. and Illarionova, V. and Fischer, M. and Siepe, I. and Schweizer, W. B. and Brun, R. and Diederich, F.. (2012) Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates. ChemMedChem, Vol. 7, H. 1. pp. 151-158.

Brunner, R. and Aissaoui, H. and Boss, C. and Bozdech, Z. and Brun, R. and Corminboeuf, O. and Delahaye, S. and Fischli, C. and Heidmann, B. and Kaiser, M. and Kamber, J. and Meyer, S. and Papastogiannidis, P. and Siegrist, R. and Voss, Till S. and Welford, R. and Wittlin, S. and Binkert, C.. (2012) Identification of a new chemical class of antimalarials. Journal of infectious diseases, Vol. 206, no. 5. pp. 735-743.

Nagle, A. and Wu, T. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Liu, B. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Chuan, T. and Alper, P. B. and Fischli, C. and Brun, R. and Lakshminarayana, S. B. and Rottmann, M. and Diagana, T. T. and Winzeler, E. A. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2012) Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of medicinal chemistry, 55 (9). pp. 4244-4273.

Wenzler, T. and Steinhuber, A. and Wittlin, S. and Scheurer, C. and Brun, R. and Trampuz, A.. (2012) Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum. PLoS neglected tropical diseases, Vol. 6, H. 6 , e1668.

Schmidt, T. J. and Rzeppa, S. and Kaiser, M. and Brun, R.. (2012) Larrea tridentata - absolute configuration of its epoxylignans and investigations on its antiprotozoal activity. Phytochemistry letters, Vol. 5, H. 3. pp. 632-637.

Faist, J. and Seebacher, W. and Saf, R. and Brun, R. and Kaiser, M. and Weis, R.. (2012) New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds. European journal of medicinal chemistry, 47 (1). pp. 510-519.

Gemma, S. and Camodeca, C. and Sanna, Coccone and Joshi, B. P. and Bernetti, M. and Moretti, V. and Brogi, S. and Bonache, M. C. and Savini, L. and Taramelli, D. and Basilico, N. and Parapini, S. and Rottmann, M. and Brun, R. and Lamponi, S. and Caccia, S. and Guiso, G. and Summer, R. and Martin, R. and Saponara, S. and Gorelli, B. and Novellino, E. and Campiani, G. and Butini, S.. (2012) Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials : further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of medicinal chemistry, 55 (15). pp. 6948-6967.

Thuita, J. K. and Wang, M. Z. and Kagira, J. M. and Denton, C. L. and Paine, M. F. and Mdachi, R. E. and Murilla, G. A. and Ching, S. and Boykin, D. W. and Tidwell, R. R. and Hall, J. E. and Brun, R.. (2012) Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 6, H. 7 , e1734.

Ge, J. F. and Zhang, Q. Q. and Lu, J. M. and Kaiser, M. and Brun, R. and Ihara, M.. (2012) Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities. MedChemComm, Vol. 3, H. 11. pp. 1435-1442.

Banerjee, M. and Farahat, A. A. and Kumar, A. and Wenzler, T. and Brun, R. and Munde, M. M. and Wilson, W. D. and Zhu, X. and Werbovetz, K. A. and Boykin, D. W.. (2012) Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides. European journal of medicinal chemistry, 55. pp. 449-454.

Stec, J. and Huang, Q. and Pieroni, M. and Kaiser, M. and Fomovska, A. and Mui, E. and Witola, W. H. and Bettis, S. and McLeod, R. and Brun, R. and Kozikowski, A. P.. (2012) Synthesis, biological evaluation and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. Journal of medicinal chemistry, 55 (7). pp. 3088-3100.

Schmidt, T. J. and Khalid, S. A. and Romanha, A. J. and Alves, T. Ma and Biavatti, M. W. and Brun, R. and Da Costa, F. B. and de Castro, S. L. and Ferreira, V. F. and de Lacerda, M. V. G. and Lago, J. H. G. and Leon, L. L. and Lopes, N. P. and das Neves Amorim, R. C. and Niehues, M. and Ogungbe, I. V. and Pohlit, A. M. and Scotti, M. T. and Setzer, W. N. and de N. C. Soeiro, M. and Steindel, M. and Tempone, A. G.. (2012) The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases : part I. Current medicinal chemistry, Vol. 19, H. 14. pp. 2128-2175.

Schmidt, T. J. and Khalid, S. A. and Romanha, A. J. and Alves, T. Ma and Biavatti, M. W. and Brun, R. and Da Costa, F. B. and de Castro, S. L. and Ferreira, V. F. and de Lacerda, M. V. G. and Lago, J. H. G. and Leon, L. L. and Lopes, N. P. and das Neves Amorim, R. C. and Niehues, M. and Ogungbe, I. V. and Pohlit, A. M. and Scotti, M. T. and Setzer, W. N. and de N. C. Soeiro, M. and Steindel, M. and Tempone, A. G.. (2012) The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases : part II. Current medicinal chemistry, Vol. 19, H. 14. pp. 2176-2228.

Ehmke, V. and Quinsaat, J. E. and Rivera-Fuentes, P. and Heindl, C. and Freymond, C. and Rottmann, M. and Brun, R. and Schirmeister, T. and Diederich, F.. (2012) Tuning and predicting biological affinity : aryl nitriles as cysteine protease inhibitors. Organic & biomolecular chemistry, Vol. 10, H. 30. pp. 5764-5768.

2011

Bourdin Trunz B., and Jedrysiak, R. and Tweats, D. and Brun, R. and Kaiser, M. and Suwinski, J. and Torreele, E.. (2011) 1-aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis. European journal of medicinal chemistry, 46 (5). pp. 1524-1535.

Maas, M. and Hensel, A. and Batista da Costa F., and Brun, R. and Kaiser, M. and Schmidt, T. J.. (2011) An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatorium perfoliatum. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 7. pp. 635-644.

Kaiser, M. and Bray, M. A. and Cal, M. and Trunz, B. B. and Torreele, E. and Brun, R.. (2011) Anti-trypanosomal activity of Fexinidazole: a new oral nitroimidazole drug candidate for the treatment of sleeping sickness. Antimicrobial agents and chemotherapy : AAC, Vol. 55, H. 12. pp. 5602-5608.

Chadwick, J. and Amewu, R. K. and Marti, F. and Bousejra-El Garah F., and Sharma, R. and Berry, N. G. and Stocks, P. A. and Burrell-Saward H., and Wittlin, S. and Rottmann, M. and Brun, R. and Taramelli, D. and Parapini, S. and Ward, S. A. and O'Neill P. M., . (2011) Antimalarial mannoxanes : hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 8. pp. 1357-1361.

Gachet, M. S. and Kunert, O. and Kaiser, M. and Brun, R. and Zehl, M. and Keller, W. and Munoz, R. A. and Bauer, R. and Schuehly, W.. (2011) Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. Journal of Natural Products, 74 (4). pp. 559-566.

Hata, Y. and Zimmermann, S. and Quitschau, M. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2011) Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids. Journal of agricultural and food chemistry, Vol. 59, H. 17. pp. 9172-9176.

Dua, V. K. and Verma, G. and Agarwal, D. D. and Kaiser, M. and Brun, R.. (2011) Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 136, H. 1. pp. 123-128.

Kirmizibekmez, H. and Atay, I. and Kaiser, M. and Brun, R. and Cartagena, M. M. and Carballeira, N. M. and Yesilada, E. and Tasdemir, D.. (2011) Antiprotozoal activity of Melampyrum arvense and its metabolites. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 25, H. 1. pp. 142-146.

Baragana, B. and McCarthy, O. and Sanchez, P. and Bosch-Navarrete C., and Kaiser, M. and Brun, R. and Whittingham, J. L. and Roberts, S. M. and Zhou, X. X. and Wilson, K. S. and Johansson, N. G. and Gonzalez-Pacanowska D., and Gilbert, I. H.. (2011) Beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (7). pp. 2378-2391.

Bouchikhi, F. and Anizon, F. and Brun, R. and Moreau, P.. (2011) Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis). Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 21. pp. 6319-6321.

Mayence, A. and Vanden Eynde J. J., and Kaiser, M. and Brun, R. and Yarlett, N. and Huang, T. L.. (2011) Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (24). pp. 7493-7500.

Liu, L. and Bruhn, T. and Guo, L. and Gotz, D. C. and Brun, R. and Stich, A. and Che, Y. and Bringmann, G.. (2011) Chloropupukeanolides C-E : cytotoxic pupukeanane chlorides with a spiroketal skeleton from Pestalotiopsis fici. Chemistry : an Asian journal / an ACES journal, Vol. 17, H. 9. pp. 2604-2613.

Schmidt, T. J. and Kaiser, M. and Brun, R.. (2011) Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata and evaluation of its antiprotozoal activity. Planta medica, 77 (8). pp. 849-850.

Bakunov, S. A. and Bakunova, S. M. and Wenzler, T. and Ghebru, M. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2011) Correction to synthesis and antiprotozoal activity of cationic1,4-diphenyl-1H-1,2,3-triazoles. Journal of medicinal chemistry, 54 (12). p. 4281.

Hampton, S. E. and Baragana, B. and Schipani, A. and Bosch-Navarrete C., and Musso-Buendia J. A., and Recio, E. and Kaiser, M. and Whittingham, J. L. and Roberts, S. M. and Shevtsov, M. and Brannigan, J. A. and Kahnberg, P. and Brun, R. and Wilson, K. S. and Gonzalez-Pacanowska D., and Johansson, N. G. and Gilbert, I. H.. (2011) Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 10. pp. 1816-1831.

Brun, R. and Don, R. and Jacobs, R. T. and Wang, M. Z. and Barrett, M. P.. (2011) Development of novel drugs for human African trypanosomiasis. Future microbiology, Vol. 6. pp. 677-691.

Ismail, M. A. and Bialy, S. A. and Brun, R. and Wenzler, T. and Nanjunda, R. and Wilson, W. D. and Boykin, D. W.. (2011) Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (2). pp. 978-984.

Gillingwater, K. and Gutierrez, C. and Bridges, A. and Wu, H. and Deborggraeve, S. and Ali Ekangu R., and Kumar, A. and Ismail, M. and Boykin, D. and Brun, R.. (2011) Efficacy study of novel diamidine compounds in a Trypanosoma evansi goat model. PLoS ONE, Vol. 6, H. 6 , e20836.

Harel, D. and Khalid, S. A. and Kaiser, M. and Brun, R. and Wunsch, B. and Schmidt, T. J.. (2011) Encecalol angelate, an unstable chromene from Ageratum conyzoides L. : total synthesis and investigation of its antiprotozoal activity. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 137, H. 1. pp. 620-650.

Farahat, A. A. and Paliakov, E. and Kumar, A. and Barghash, A. E. and Goda, F. E. and Eisa, H. M. and Wenzler, T. and Brun, R. and Liu, Y. and Wilson, W. D. and Boykin, D. W.. (2011) Exploration of larger central ring linkers in furamidine analogues : synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (7). pp. 2156-2167.

Hobbie, S. N. and Kaiser, M. and Schmidt, S. and Shcherbakov, D. and Janusic, T. and Brun, R. and Böttger, E. C.. (2011) Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma. PLoS neglected tropical diseases, Vol. 5, H. 5 , e1161.

Munigunti, R. and Nelson, N. and Mulabagal, V. and Gupta, M. P. and Brun, R. and Calderón, A. I.. (2011) Identification of oleamide in Guatteria recurvisepala by LC/MS-Based Plasmodium falciparum thioredoxin reductase ligand binding method. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 77, H. 15. pp. 1749-1753.

Wu, T. and Nagle, A. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Goh, A. and Lakshminarayana, S. B. and Wu, J. and Ang, H. Q. and Zeng, P. and Kang, M. L. and Tan, W. and Tan, M. and Ye, N. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Fischli, C. and Brun, R. and Rottmann, M. and Dartois, V. and Keller, T. and Diagana, T. and Winzeler, E. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2011) Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of medicinal chemistry, 54 (14). pp. 5116-5130.

Eberle, C. and Lauber, B. S. and Fankhauser, D. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Diederich, F.. (2011) Improved inhibitors of trypanothione reductase by combination of motifs : synthesis, inhibitory potency, binding mode, and antiprotozoal activities. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 292-301.

Ruda, G. F. and Nguyen, C. and Ziemkowski, P. and Felczak, K. and Kasinathan, G. and Musso-Buendia A., and Sund, C. and Zhou, X. X. and Kaiser, M. and Ruiz-Perez L. M., and Brun, R. and Kulikowski, T. and Johansson, N. G. and Gonzalez-Pacanowska D., and Gilbert, I. H.. (2011) Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 309-320.

Arafa, R. K. and Wenzler, T. and Brun, R. and Chai, Y. and Wilson, D.. (2011) Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents. European journal of medicinal chemistry, 46 (12). pp. 5852-5860.

Papadopoulou, M. V. and Bourdin, B. and Bloomer, W. D. and McKenzie, C. and Wilkinson, S. R. and Prasittichai, C. and Brun, R. and Kaiser, M. and Torreele, E.. (2011) Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents. Journal of medicinal chemistry, 54 (23). pp. 8214-8223.

Nehrbass-Stuedli A., and Boykin, D. and Tidwell, R. R. and Brun, R.. (2011) Novel diamidines with activity against Babesia divergens in Vitro and Babesia microti in Vivo. Antimicrobial agents and chemotherapy : AAC, Vol. 55, H. 7. pp. 3439-3445.

Bringmann, G. and Hertlein-Amslinger B., and Kajahn, I. and Dreyer, M. and Brun, R. and Moll, H. and Stich, A. and Ioset, K. N. and Schmitz, W. and Ngoc, L. H.. (2011) Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 1. pp. 89-93.

Ehmke, V. and Heindl, C. and Rottmann, M. and Freymond, C. and Schweizer, W. B. and Brun, R. and Stich, A. and Schirmeister, T. and Diederich, F.. (2011) Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 273-278.

Jacobs, R. T. and Naré, B. and Wring, S. A. and Orr, M. D. and Chen, D. and Sligar, J. M. and Jenks, M. X. and Noe, R. A. and Bowling, T. S. and Mercer, L. T. and Rewerts, C. and Gaukel, E. and Owens, J. and Parham, R. and Randolph, R. and Beaudet, B. and Bacchi, C. J. and Yarlett, N. and Plattner, J. J. and Freund, Y. and Ding, C. and Akama, T. and Zhang, Y. K. and Brun, R. and Kaiser, M. and Scandale, I. and Don, R.. (2011) SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 Human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 5, H. 6 , e1151.

Mokoka, T. A. and Zimmermann, S. and Julianti, T. and Hata, Y. and Moodley, N. and Cal, M. and Adams, M. and Kaiser, M. and Brun, R. and Koorbanally, N. and Hamburger, M.. (2011) Screening South African medicinal plants for bioactive constituents against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani and Plasmodium falciparum. Planta medica, Vol. 77, H. 14. pp. 1663-1667.

Nieto, L. and Mascaraque, A. and Miller, F. and Glacial, F. and Rios Martinez C., and Kaiser, M. and Brun, R. and Dardonville, C.. (2011) Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability. Journal of medicinal chemistry, 54 (2). pp. 485-494.

Reid, C. S. and Patrick, D. A. and He, S. and Fotie, J. and Premalatha, K. and Tidwell, R. R. and Wang, M. Z. and Liu, Q. and Gershkovich, P. and Wasan, K. M. and Wenzler, T. and Brun, R. and Werbovetz, K. A.. (2011) Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols : effect of core substitutions and salt formation. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (1). pp. 513-523.

Shi, X. L. and Ge, J. F. and Liu, B. Q. and Kaiser, M. and Wittlin, S. and Brun, R. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 19. pp. 5804-5807.

Lu, Y. T. and Arai, C. and Ge, J. F. and Ren, W. S. and Kaiser, M. and Wittlin, S. and Brun, R. and Lu, J. M. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides. Dyes and pigments : an international journal, Vol. 89, H. 1. pp. 44-48.

Charman, S. A. and Arbe-Barnes S., and Bathurst, I. C. and Brun, R. and Campbell, M. and Charman, W. N. and Chiu, F. C. and Chollet, J. and Craft, J. C. and Creek, D. J. and Dong, Y. and Matile, H. and Maurer, M. and Morizzi, J. and Nguyen, T. and Papastogiannidis, P. and Scheurer, C. and Shackleford, D. M. and Sriraghavan, K. and Stingelin, L. and Tang, Y. and Urwyler, H. and Wang, X. and White, K. L. and Wittlin, S. and Zhou, L. and Vennerstrom, J. L.. (2011) Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 11. pp. 4400-4405.

Moridi Farimani M., and Bahadori, M. B. and Taheri, S. and Ebrahimi, S. N. and Zimmermann, S. and Brun, R. and Amin, G. and Hamburger, M.. (2011) Triterpenoids with rare carbon skeletons from Salvia hydrangea : antiprotozoal activity and absolute configurations. Journal of Natural Products, Vol. 74, H. 10. pp. 2200-2205.

2010

Tasdemir, D. and Sanabria, D. and Lauinger, I. L. and Tarun, A. and Herman, R. and Perozzo, R. and Zloh, M. and Kappe, S. H. and Brun, R. and Carballeira, N. M.. (2010) 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorganic and Medicinal Chemistry, 18 (21). pp. 7475-7485.

Brun, R. and Stich, A.. (2010) Afrikanische Trypanosomiasis oder Schlafkrankheit. In: Tropenmedizin in Klinik und Praxis : mit Reise- und Migrationsmedizin. Stuttgart, pp. 617-629.

Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2010) Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities. European Journal of Medicinal Chemistry, 45 (1). pp. 179-185.

Wright, C. W. and Linley, P. A. and Brun, R. and Wittlin, S. and Hsu, E.. (2010) Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity. Molecules, Vol. 15, H. 2. pp. 804-812.

Bonazzi, S. and Barbaras, D. and Patiny, L. and Scopelliti, R. and Schneider, P. and Cole, S. T. and Kaiser, M. and Brun, R. and Gademann, K.. (2010) Antimalarial and antitubercular nostocarboline and eudistomin derivatives: Synthesis, in vitro and in vivo biological evaluation. Bioorganic and Medicinal Chemistry, 18 (4). pp. 1464-1476.

Wenzel, N. I. and Chavain, N. and Wang, Y. and Friebolin, W. and Maes, L. and Pradines, B. and Lanzer, M. and Yardley, V. and Brun, R. and Herold-Mende C., and Biot, C. and Toth, K. and Davioud-Charvet E., . (2010) Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA. Journal of Medicinal Chemistry, 53 (8). pp. 3214-3226.

Adams, M. and Christen, M. and Plitzko, I. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2010) Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. Journal of Natural Products, Vol. 73, H. 5. pp. 897-900.

Gachet, M. S. and Lecaro, J. S. and Kaiser, M. and Brun, R. and Navarrete, H. and Munoz, R. A. and Bauer, R. and Schuhly, W.. (2010) Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 128, H. 1. pp. 184-197.

Oberle, M. and Balmer, O. and Brun, R. and Roditi, I.. (2010) Bottlenecks and the maintenance of minor genotypes during the life cycle of Trypanosoma brucei. PLoS Pathogens, Vol. 6, H. 7 , e1001023.

Abiodun, O. O. and Gbotosho, G. O. and Ajaiyeoba, E. O. and Happi, C. T. and Hofer, S. and Wittlin, S. and Sowunmi, A. and Brun, R. and Oduola, A. M. J.. (2010) Comparison of SYBR Green I-, PicoGreen-, and [H-3]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 106, H. 4. pp. 933-939.

Gigante, F. and Kaiser, M. and Brun, R. and Gilbert, I. H.. (2010) Design and preparation of sterol mimetics as potential antiparasitics. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (20). pp. 7291-7301.

Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2010) Dialkylaminoalkyl derivatives of bicyclic compounds with antiplasmodial activity. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (18). pp. 6796-6804.

Paine, M. F. and Wang, M. Z. and Generaux, C. N. and Boykin, D. W. and Wilson, W. D. and de Koning H. P., and Olson, C. A. and Pohlig, G. and Burri, C. and Brun, R. and Murilla, G. A. and Thuita, J. K. and Barrett, M. P. and Tidwell, R. R.. (2010) Diamidines for human African trypanosomiasis. Current opinion in investigational drugs, Vol. 11, H. 8. pp. 876-883.

Ge, J. F. and Arai, C. and Yang, M. and Bakar, M. A. and Lu, J. and Ismail, N. S. M. and Wittlin, S. and Kaiser, M. and Brun, R. and Charman, S. A. and Nguyen, T. and Morizzi, J. and Itoh, I. and Ihara, M.. (2010) Discovery of novel benzo[a]phenoxazine SSJ-183 as a drug candidate for malaria. ACS medicinal chemistry letters, Vol. 1, H. 7. pp. 360-364.

Nare, B. and Wring, S. and Bacchi, C. and Beaudet, B. and Bowling, T. and Brun, R. and Chen, D. and Ding, C. and Freund, Y. and Gaukel, E. and Hussain, A. and Jarnagin, K. and Jenks, M. and Kaiser, M. and Mercer, L. and Mejia, E. and Noe, A. and Orr, M. and Parham, R. and Plattner, J. and Randolph, R. and Rattendi, D. and Rewerts, C. and Sligar, J. and Yarlett, N. and Don, R. and Jacobs, R.. (2010) Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late stage central nervous system African Trypanosomiasis. Antimicrobial agents and chemotherapy : AAC, Vol. 54, H. 10. pp. 4379-4388.

Torreele, E. and BourdinTrunz, B. and Tweats, D. and Kaiser, M. and Brun, R. and Mazue, G. and Bray, M. A. and Pecoul, B.. (2010) Fexinidazole: a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS neglected tropical diseases, Vol. 4, H. 12 , e923.

Yang, M. and Arai, C. and Bakar, M. A. and Lu, J. and Ge, J. F. and Pudhom, K. and Takasu, K. and Kasai, K. and Kaiser, M. and Brun, R. and Yardley, V. and Itoh, I. and Ihara, M.. (2010) Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL). Journal of medicinal chemistry, 53 (1). pp. 368-373.

Brun, R. and Blum, J. and Chappuis, F. and Burri, C.. (2010) Human African trypanosomiasis. Lancet, Vol. 375, no. 9709. pp. 148-159.

O'Neill P. M., and Amewu, R. K. and Nixon, G. L. and Bousejra, E. F. and Mungthin, M. and Chadwick, J. and Shone, A. E. and Vivas, L. and Lander, H. and Barton, V. and Muangnoicharoen, S. and Bray, P. G. and Davies, J. and Park, B. K. and Wittlin, S. and Brun, R. and Preschel, M. and Zhang, K. and Ward, S. A.. (2010) Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins. Angewandte Chemie. International edition in English, Vol. 49, H. 33. pp. 5693-5697.

Gillingwater, K. and Kumar, A. and Ismail, M. A. and Arafa, R. K. and Stephens, C. E. and Boykin, D. W. and Tidwell, R. R. and Brun, R.. (2010) In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi. Veterinary parasitology : an international scientific journal, Vol. 169. pp. 264-272.

Zohrabi-Kalantari, V. and Heidler, P. and Kaiser, M. and Brun, R. and Kamper, C. and Link, A.. (2010) Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N(6)-substituted 5 (`)-amino-5 (`)-deoxyadenosines. Molecular Diversity, 14 (2). pp. 307-320.

Zohrabi-Kalantari, V. and Heidler, P. and Kaiser, M. and Brun, R. and Kamper, C. and Link, A.. (2010) Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines. Molecular Diversity, 14 (2). pp. 307-320.

Gachet, M. S. and Kunert, O. and Kaiser, M. and Brun, R. and Munoz, R. A. and Bauer, R. and Schuhly, W.. (2010) Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum. Journal of Natural Products, Vol. 73, H. 4. pp. 553-556.

Pacorel, B. and Leung, S. C. and Stachulski, A. V. and Davies, J. and Vivas, L. and Lander, H. and Ward, S. A. and Kaiser, M. and Brun, R. and O'Neill P. M., . (2010) Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin. Journal of medicinal chemistry, 53 (2). pp. 633-640.

Mallari, J. P. and Zhu, F. and Lemoff, A. and Kaiser, M. and Lu, M. and Brun, R. and Guy, R. K.. (2010) Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (23). pp. 8302-8309.

Nzila, A. and Rottmann, M. and Chitnumsub, P. and Kiara, S. M. and Kamchonwongpaisan, S. and Maneeruttanarungroj, C. and Taweechai, S. and Yeung, B. K. and Goh, A. and Lakshminarayana, S. B. and Zou, B. and Wong, J. and Ma, N. L. and Weaver, M. and Keller, T. H. and Dartois, V. and Wittlin, S. and Brun, R. and Yuthavong, Y. and Diagana, T. T.. (2010) Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrobial agents and chemotherapy : AAC, Vol. 54, H. 6. pp. 2603-2610.

Bringmann, G. and Bischof, S. K. and Müller, S. and Gulder, T. and Winter, C. and Stich, A. and Moll, H. and Kaiser, M. and Brun, R. and Dreher, J. and Baumann, K.. (2010) QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. European journal of medicinal chemistry, 45 (11). pp. 5370-5383.

Xu, M. and Bruhn, T. and Hertlein, B. and Brun, R. and Stich, A. and Wu, J. and Bringmann, G.. (2010) Shuangancistrotectorines A-E, dimeric naphthylisoquinoline alkaloids with three chiral biaryl axes from the Chinese plant Ancistrocladus tectorius. Chemistry : a European journal, Vol. 16, H. 14. pp. 4206-4216.

Rottmann, M. and McNamara, C. and Yeung, B. K. and Lee, M. C. and Zou, B. and Russell, B. and Seitz, P. and Plouffe, D. M. and Dharia, N. V. and Tan, J. and Cohen, S. B. and Spencer, K. R. and Gonzalez-Paez G. E., and Lakshminarayana, S. B. and Goh, A. and Suwanarusk, R. and Jegla, T. and Schmitt, E. K. and Beck, H. P. and Brun, R. and Nosten, F. and Renia, L. and Dartois, V. and Keller, T. H. and Fidock, D. A. and Winzeler, E. A. and Diagana, T. T.. (2010) Spiroindolones, a potent compound class for the treatment of malaria. Science, Vol. 329, no. 5996. pp. 1175-1180.

Yeung, B. K. and Zou, B. and Rottmann, M. and Lakshminarayana, S. B. and Ang, S. H. and Leong, S. Y. and Tan, J. and Wong, J. and Keller-Maerki S., and Fischli, C. and Goh, A. and Schmitt, E. K. and Krastel, P. and Francotte, E. and Kuhen, K. and Plouffe, D. and Henson, K. and Wagner, T. and Winzeler, E. A. and Petersen, F. and Brun, R. and Dartois, V. and Diagana, T. T. and Keller, T. H.. (2010) Spirotetrahydro beta-carbolines (spiroindolones) : a new class of potent and orally efficacious compounds for the treatment of malaria. Journal of Medicinal Chemistry, 53 (14). pp. 5155-5164.

Branowska, D. and Farahat, A. A. and Kumar, A. and Wenzler, T. and Brun, R. and Liu, Y. and Wilson, W. D. and Boykin, D. W.. (2010) Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. Bioorganic & Medicinal Chemistry, 18 (10). pp. 3551-3558.

Bakunov, S. A. and Bakunova, S. M. and Wenzler, T. and Ghebru, M. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2010) Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. Journal of Medicinal Chemistry, 53 (1). pp. 254-272.

Farahat, A. A. and Kumar, A. and Say, M. and Barghash Aedm, and Goda, F. E. and Eisa, H. M. and Wenzler, T. and Brun, R. and Liu, Y. and Mickelson, L. and Wilson, W. D. and Boykin, D. W.. (2010) Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines. Bioorganic & Medicinal Chemistry, 18 (2). pp. 557-566.

Pagliero, R. J. and Lusvarghi, S. and Pierini, A. B. and Brun, R. and Mazzieri, M. R.. (2010) Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines. Bioorganic & Medicinal Chemistry, 18 (1). pp. 142-150.

Burgess, S. J. and Kelly, J. X. and Shomloo, S. and Wittlin, S. and Brun, R. and Liebmann, K. and Peyton, D. H.. (2010) Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds. Journal of medicinal chemistry, 53 (17). pp. 6477-6489.

Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R. and Abdalla, W. E. and Schmidt, T. J.. (2010) The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L. Journal of Ethnopharmacology, Vol. 129, H. 1. pp. 127-130.

Dong, Y. and Wittlin, S. and Sriraghavan, K. and Chollet, J. and Charman, S. A. and Charman, W. N. and Scheurer, C. and Urwyler, H. and Santo, T. J. and Snyder, C. and Creek, D. J. and Morizzi, J. and Koltun, M. and Matile, H. and Wang, X. and Padmanilayam, M. and Tang, Y. and Dorn, A. and Brun, R. and Vennerstrom, J. L.. (2010) The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). Journal of Medicinal Chemistry, 53 (1). pp. 481-491.

2009

Tritten, L. and Matile, H. and Brun, R. and Wittlin, S.. (2009) A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity. Malaria Journal, Vol. 8 , 226.

Kuettel, S. and Mosimann, M. and Mäser, P. and Kaiser, M. and Brun, R. and Scapozza, L. and Perozzo, R.. (2009) Adenosine kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics. PLoS Neglected Tropical Diseases, Vol. 3, H. 8 , e506.

Nwaka, S. and Ramirez, B. and Brun, R. and Maes, L. and Douglas, F. and Ridley, R.. (2009) Advancing drug innovation for neglected diseases-criteria for lead progression. PLoS Neglected Tropical Diseases, Vol. 3, H. 8 , e440.

Adams, M. and Plitzko, I. and Kaiser, M. and Brun, R. and Hamburger, M.. (2009) Anti-plasmodial flavonoid from Pistacia atlantica. Phytochemistry Letters, Vol. 2. pp. 159-162.

Chavain, N. and Davioud-Charvet E., and Trivelli, X. and Mbeki, L. and Rottmann, M. and Brun, R. and Biot, C.. (2009) Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 17 (23). pp. 8048-8059.

Schlapper, C. and Seebacher, W. and Faist, J. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates. European journal of medicinal chemistry, 44 (2). pp. 736-744.

Faist, J. and Seebacher, W. and Schlapper, C. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 17 (10). pp. 3595-3603.

Malebo, H. M. and Wenzler, T. and Cal, M. and Swaleh, S. A. and Omolo, M. O. and Hassanali, A. and Sequin, U. and Hamburger, M. and Brun, R. and Ndiege, I. O.. (2009) Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants. Tanzania journal of health research, Vol. 11, H. 4. pp. 226-234.

Malebo, H. M. and Tanja, W. and Cal, M. and Swaleh, S. A. M. and Omolo, M. O. and Hassanali, A. and Séquin, U. and Hamburger, M. and Brun, R. and Ndiege, I. O.. (2009) Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants. Tanzania Journal of Health Research, 11 (4). pp. 226-234.

Dardonville, C. and Fernandez-Fernandez C., and Gibbons, S. L. and Jagerovic, N. and Nieto, L. and Ryan, G. and Kaiser, M. and Brun, R.. (2009) Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 9. pp. 3815-3821.

Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Bicyclic amido compounds with antiprotozoal activity. Monatshefte für Chemie = Chemical monthly : an international journal of chemistry, Vol. 140, H. 10. pp. 1261-1268.

Musonda, C. C. and Whitlock, G. A. and Witty, M. J. and Brun, R. and Kaiser, M.. (2009) Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 2. pp. 481-484.

Gemma, S. and Campiani, G. and Butini, S. and Joshi, B. P. and Kukreja, G. and Coccone, S. S. and Bernetti, M. and Persico, M. and Nacci, V. and Fiorini, I. and Novellino, E. and Taramelli, D. and Basilico, N. and Parapini, S. and Yardley, V. and Croft, S. and Keller-Maerki S., and Rottmann, M. and Brun, R. and Coletta, M. and Marini, S. and Guiso, G. and Caccia, S. and Fattorusso, C.. (2009) Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. Journal of Medicinal Chemistry, 52 (2). pp. 502-513.

Ganapaty, S. and Srilakshmi, G. V. and Pannakal, S. T. and Rahman, H. and Laatsch, H. and Brun, R.. (2009) Cytotoxic benzil and coumestan derivatives from Tephrosia calophylla. Phytochemistry : an international journal of plant biochemistry, Vol. 70, H. 1. pp. 95-99.

McCarthy, O. and Musso-Buendia A., and Kaiser, M. and Brun, R. and Ruiz-Perez L. M., and Johansson, N. G. and Pacanowska, D. G. and Gilbert, I. H.. (2009) Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. European journal of medicinal chemistry, 44 (2). pp. 678-688.

Kelly, J. X. and Smilkstein, M. J. and Brun, R. and Wittlin, S. and Cooper, R. A. and Lane, K. D. and Janowsky, A. and Johnson, R. A. and Dodean, R. A. and Winter, R. and Hinrichs, D. J. and Riscoe, M. K.. (2009) Discovery of dual function acridones as a new antimalarial chemotype. Nature, Vol. 459, H. 7244. pp. 270-273.

Mdachi, R. E. and Thuita, J. K. and Kagira, J. M. and Ngotho, J. M. and Murilla, G. A. and Ndung'u J. M., and Tidwell, R. R. and Hall, J. E. and Brun, R.. (2009) Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 3. pp. 953-957.

Christen, M. and Adams, M. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2009) HPLC based activity profiling of Ganoderma lucidum extract for antiplasmodial activity and isolation of new active lanostane triterpenoids. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 948.

Adams, M. and Plitzko, I. and Kaiser, M. and Brun, R. and Hamburger, M.. (2009) HPLC-profiling for antiplasmodial compounds-3-methoxycarpachromene from Pistacia atlantica. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 948.

Nwodo, N. J. and Omeje, E. O. and Brun, R.. (2009) In vitro-in vivo studies on anti-trypanosomal potentials of Zapoteca portoricensis. Asian pacific journal of tropical medicine, Vol. 2, H. 1. pp. 25-29.

Gillingwater, K. and Kumar, A. and Anbazhagan, M. and Boykin, D. W. and Tidwell, R. R. and Brun, R.. (2009) In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 12. pp. 5074-5079.

Heidler, P. and Zohrabi-Kalantari V., and Kaiser, M. and Brun, R. and Emmrich, T. and Link, A.. (2009) Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine derivatives. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 4. pp. 1428-1436.

Balmer, O. and Stearns, S. C. and Schotzau, A. and Brun, R.. (2009) Intraspecific competition between co-infecting parasite strains enhances host survival in African trypanosomes. Ecology : a publication of the Ecological Society of America, Vol. 90, Nr. 12. pp. 3367-3378.

Gachet, M. S. and Schuhly, W. and Kunert, O. and Kaiser, M. and Brun, R. and Munoz, R. A. and Bauer, R.. (2009) Jacaranone derived glucosidic esters from Jacaranda glabra. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. pp. 901-902.

Riente, R. R. and Souza, V. P. and Carvalho, S. A. and Kaiser, M. and Brun, R. and da Silva E. F., . (2009) Leishmanicidal activity of new megazol derivatives. Medicinal chemistry, Vol. 5, H. 4. pp. 392-397.

Vassella, E. and Oberle, M. and Urwyler, S. and Renggli, C. K. and Studer, E. and Hemphill, A. and Fragoso, C. and Butikofer, P. and Brun, R. and Roditi, I.. (2009) Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse. PLoS ONE, Vol. 4, H. 2 , e4493.

Portmann, C. and Blom, J. F. and Kaiser, M. and Brun, R. and Juttner, F. and Gademann, K.. (2009) New antiplasmodial natural products from cyanobacteria: linking their ecological role to their therapeutic potential. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 886.

Wenzler, T. and Boykin, D. W. and Ismail, M. A. and Hall, J. E. and Tidwell, R. R. and Brun, R.. (2009) New treatment option for second stage African sleeping sickness: In vitro and in vivo efficacy of aza analogs of DB289. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 10. pp. 4185-4192.

Baliani, A. and Peal, V. and Gros, L. and Brun, R. and Kaiser, M. and Barrett, M. P. and Gilbert, I. H.. (2009) Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 7, H. 6. pp. 1154-1166.

Efange, S. M. and Brun, R. and Wittlin, S. and Connolly, J. D. and Hoye, T. R. and McAkam, T. and Makolo, F. L. and Mbah, J. A. and Nelson, D. P. and Nyongbela, K. D. and Wirmum, C. K.. (2009) Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity. Journal of Natural Products, Vol. 72, H. 2. pp. 280-283.

Stump, B. and Eberle, C. and Schweizer, W. B. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Lentz, D. and Diederich, F.. (2009) Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines. ChemBioChem : a European journal of chemical biology, Vol. 10, H. 1. pp. 79-83.

Kiboi, D. M. and Irungu, B. N. and Langat, B. and Wittlin, S. and Brun, R. and Chollet, J. and Abiodun, O. and Nganga, J. K. and Nyambati, V. C. and Rukunga, G. M. and Bell, A. and Nzila, A.. (2009) Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model. Experimental parasitology : EP, Vol. 122, H. 3. pp. 196-202.

Cavalli, A. and Lizzi, F. and Bongarzone, S. and Brun, R. and Luise Krauth-Siegel R., and Bolognesi, M. L.. (2009) Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 11. pp. 3031-3035.

Schmidt, T. J. and Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R.. (2009) Quantitative structure--antiprotozoal activity relationships of sesquiterpene lactones. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 14, H. 6. pp. 2062-2076.

Gigante, F. and Kaiser, M. and Brun, R. and Gilbert, I. H.. (2009) SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 16. pp. 5950-5961.

Berger, H. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols. Monatshefte für Chemie = Chemical monthly : an international journal of chemistry, Vol. 140, H. 5. pp. 495-502.

Huang, Q. and Mao, J. and Wan, B. and Wang, Y. and Brun, R. and Franzblau, S. G. and Kozikowski, A. P.. (2009) Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles. Journal of Medicinal Chemistry, 52 (21). pp. 6757-6767.

Van Baelen G., and Hostyn, S. and Dhooghe, L. and Tapolcsanyi, P. and Matyus, P. and Lemiere, G. and Dommisse, R. and Kaiser, M. and Brun, R. and Cos, P. and Maes, L. and Hajos, G. and Riedl, Z. and Nagy, I. and Maes, B. U. and Pieters, L.. (2009) Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 20. pp. 7209-7217.

Bakunova, S. M. and Bakunov, S. A. and Patrick, D. A. and Kumar, E. V. and Ohemeng, K. A. and Bridges, A. S. and Wenzler, T. and Barszcz, T. and Jones, S. K. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Structure-activity study of pentamidine analogues as antiprotozoal agents. Journal of Medicinal Chemistry, 52 (7). pp. 2016-2035.

Hu, L. and Arafa, R. K. and Ismail, M. A. and Patel, A. and Munde, M. and Wilson, W. D. and Wenzler, T. and Brun, R. and Boykin, D. W.. (2009) Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 18. pp. 6651-6658.

Alp, M. and Göker, H. and Brun, R. and Yildiz, S.. (2009) Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines. European Journal of Medicinal Chemistry, 44 (5). pp. 2002-2008.

Patrick, D. A. and Bakunov, S. A. and Bakunova, S. M. and Suresh Kumar E. V., and Chen, H. and Jones, S. K. and Wenzler, T. and Barzcz, T. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. European Journal of Medicinal Chemistry, 44 (9). pp. 3543-3551.

Bakunova, S. M. and Bakunov, S. A. and Wenzler, T. and Barszcz, T. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine. Journal of Medicinal Chemistry, 52 (15). pp. 4657-4667.

Bakunov, S. A. and Bakunova, S. M. and Bridges, A. S. and Wenzler, T. and Barszcz, T. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif. Journal of Medicinal Chemistry, 52 (18). pp. 5763-5767.

Pudhom, K. and Ge, M. F. and Arai, C. and Yang, M. and Kaiser, M. and Wittlin, S. and Brun, R. and Itoh, I. and Ihara, M.. (2009) Synthesis and biological properties of a rhodacyanine derivative, Ssj-127, having high efficacy against malaria protozoa. Heterocycles : an international journal for reviews and communications in heterocyclic chemistry, Vol. 77, H. 1. pp. 207-210.

Musonda, C. C. and Whitlock, G. A. and Witty, M. J. and Brun, R. and Kaiser, M.. (2009) Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 2. pp. 401-405.

Link, A. and Heidler, P. and Kaiser, M. and Brun, R.. (2009) Synthesis of a series of N(6)-substituted adenosines with activity against trypanosomatid parasites. European Journal of Medicinal Chemistry, 44 (9). pp. 3665-3671.

Wolkinger, V. and Weis, R. and Belaj, F. and Kaiser, M. and Brun, R. and Saf, R. and Seebacher, W.. (2009) Synthesis of novel diazabicycles and their antiprotozoal activities. Australian journal of chemistry, Vol. 62, H. 9. pp. 1166-1172.

Ma, X. and Zhou, W. and Brun, R.. (2009) Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 3. pp. 986-989.

Eberle, C. and Burkhard, J. A. and Stump, B. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Diederich, F.. (2009) Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds. ChemMedChem : chemistry enabling drug discovery, Vol. 4, H. 12. pp. 2034-2044.

Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R. and Abdallah, W. E. and Schmidt, T. J.. (2009) The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 2. pp. 1363-1368.

Holloway, G. A. and Charman, W. N. and Fairlamb, A. H. and Brun, R. and Kaiser, M. and Kostewicz, E. and Novello, P. M. and Parisot, J. P. and Richardson, J. and Street, I. P. and Watson, K. G. and Baell, J. B.. (2009) Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 7. pp. 2824-2833.

2008

Wang, Y. and Utzinger, J. and Saric, J. and Li, J. V. and Burckhardt, J. and Dirnhofer, S. and Nicholson, J. K. and Singer, B. H. and Brun, R. and Holmes, E.. (2008) Global metabolic responses of mice to Trypanosoma brucei brucei infection. Proceedings of the National Academy of Sciences of the United States of America, Vol. 105. pp. 6127-6132.

Portmann, C. and Blom, J. F. and Kaiser, M. and Brun, R. and Juttner, F. and Gademann, K.. (2008) Isolation of aerucyclamides C and D and structure revision of microcyclamide 7806A: heterocyclic ribosomal peptides from Microcystis aeruginosa PCC 7806 and their antiparasite evaluation. Journal of natural products, Vol. 71, H. 11. pp. 1891-1896.

This list was generated on Sun Sep 20 19:00:14 2020 CEST.