Items where Author is "Broz, Petr"

2023

Degen, Morris and Santos, José Carlos and Pluhackova, Kristyna and Cebrero, Gonzalo and Ramos, Saray and Jankevicius, Gytis and Hartenian, Ella and Guillerm, Undina and Mari, Stefania A. and Kohl, Bastian and Müller, Daniel J. and Schanda, Paul and Maier, Timm and Perez, Camilo and Sieben, Christian and Broz, Petr and Hiller, Sebastian. (2023) Structural basis of NINJ1-mediated plasma membrane rupture in cell death. Nature, 618. pp. 1065-1071.

2021

Hiller, Sebastian and Broz, Petr. (2021) Active membrane rupture spurs a range of cell deaths. Nature, 591 (7848). pp. 36-37.

2020

Santos, José Carlos and Boucher, Dave and Schneider, Larisa Kapinos and Demarco, Benjamin and Dilucca, Marisa and Shkarina, Kateryna and Heilig, Rosalie and Chen, Kaiwen W. and Lim, Roderick Y. H. and Broz, Petr. (2020) Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria. Nature Communications, 11 (1). p. 3276.

28 May 2019

Eren, Elif and Planes, Rémi and Buyck, Julien and Bordignon, Pierre-Jean and Colom, André and Cunrath, Olivier and Dreier, Roland F. and Santos, José C. and Duplan-Eche, Valérie and Näser, Emmanuelle and Peixoto, Antonio and Bumann, Dirk and Cougoule, Céline and Coste, Agnès and Neyrolles, Olivier and Broz, Petr and Meunier, Etienne. (2019) Type-3 Secretion System-induced pyroptosis protects Pseudomonas against cell-autonomous immunity.

2019

Laventie, Benoît-Joseph and Sangermani, Matteo and Estermann, Fabienne and Manfredi, Pablo and Planes, Rémi and Hug, Isabelle and Jaeger, Tina and Meunier, Etienne and Broz, Petr and Jenal, Urs. (2019) A surface-induced asymmetric program promotes tissue colonization by Pseudomonas aeruginosa. Cell host & microbe, 25 (1). pp. 140-152.E6.

Mazur, Adam and Broz, Petr and Hiller, Sebastian. (2019) An integrative protocol for the structure determination of the mouse ASC-PYD filament. In: Methods in Enzymology, 625. New York, pp. 205-222.

Dreier, Roland Felix and Ahrné, Erik and Broz, Petr and Schmidt, Alexander. (2019) Global Ion Suppression Limits the Potential of Mass Spectrometry Based Phosphoproteomics. Journal of proteome research, 18 (1). pp. 493-507.

2018

Sborgi, Lorenzo and Ude, Johanna and Dick, Mathias S. and Vesin, Johnathan and Chambon, Marc and Turcatti, Gerardo and Broz, Petr and Hiller, Sebastian. (2018) Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament. Cell Stress, 2 (4). pp. 82-90.

Heilig, Rosalie and Broz, Petr. (2018) Function and mechanism of the pyrin inflammasome. EUROPEAN JOURNAL OF IMMUNOLOGY, 48 (2). pp. 230-238.

Brodmann, Maj and Heilig, Rosalie and Broz, Petr and Basler, Marek. (2018) Mobilizable Plasmids for Tunable Gene Expression in Francisella novicida. Frontiers in cellular and infection microbiology, 8. p. 284.

Heilig, Rosalie and Dick, Mathias S. and Sborgi, Lorenzo and Meunier, Etienne and Hiller, Sebastian and Broz, Petr. (2018) The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice. European journal of immunology, 48 (4). pp. 584-592.

2017

Meunier, Etienne and Broz, Petr. (2017) Evolutionary Convergence and Divergence in NLR Function and Structure. Trends in Immunology, 38 (10). pp. 744-757.

Brodmann, Maj and Dreier, Roland F. and Broz, Petr and Basler, Marek. (2017) Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape. Nature Communications, 8. p. 15853.

Wallet, Pierre and Benaoudia, Sacha and Mosnier, Amandine and Lagrange, Brice and Martin, Amandine and Lindgren, Helena and Golovliov, Igor and Michal, Fanny and Basso, Pauline and Djebali, Sophia and Provost, Angelina and Allatif, Omran and Meunier, Etienne and Broz, Petr and Yamamoto, Masahiro and Py, Bénédicte F. and Faudry, Eric and Sjöstedt, Anders and Henry, Thomas. (2017) IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection. PLoS Pathogens, 13 (10). e1006630.

Schneider, Katharina S. and Groß, Christina J. and Dreier, Roland F. and Saller, Benedikt S. and Mishra, Ritu and Gorka, Oliver and Heilig, Rosalie and Meunier, Etienne and Dick, Mathias S. and Ćiković, Tamara and Sodenkamp, Jan and Médard, Guillaume and Naumann, Ronald and Ruland, Jürgen and Kuster, Bernhard and Broz, Petr and Groß, Olaf. (2017) The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. Cell Reports, 21 (13). pp. 3846-3859.

15 August 2016

Sborgi, Lorenzo and Rühl, Sebastian and Mulvihill, Estefania and Pipercevic, Joka and Heilig, Rosalie and Stahlberg, Henning and Farady, Christopher J. and Müller, Daniel J. and Broz, Petr and Hiller, Sebastian. (2016) GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. The EMBO Journal, 35 (16). pp. 1766-1778.

9 August 2016

Di Micco, Antonia and Frera, Gianluca and Lugrin, Jérôme and Jamilloux, Yvan and Hsu, Erh-Ting and Tardivel, Aubry and De Gassart, Aude and Zaffalon, Léa and Bujisic, Bojan and Siegert, Stefanie and Quadroni, Manfredo and Broz, Petr and Henry, Thomas and Hrycyna, Christine A. and Martinon, Fabio. (2016) AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity. Proceedings of the National Academy of Sciences of the United States of America, 113 (32). E4671-E4680.

August 2016

Broz, Petr. (2016) Inflammasomes: Intracellular detection of extracellular bacteria. Cell research, 26 (8). pp. 859-860.

July 2016

Broz, Petr and Dixit, Vishva M.. (2016) Inflammasomes: mechanism of assembly, regulation and signalling. Nature reviews. Immunology, 16 (7). pp. 407-420.

February 2016

Meunier, Etienne and Broz, Petr. (2016) Interferon-inducible GTPases in cell autonomous and innate immunity. Cellular microbiology, 18 (2). pp. 168-180.

2016

Dick, Mathias S. and Sborgi, Lorenzo and Rühl, Sebastian and Hiller, Sebastian and Broz, Petr. (2016) ASC filament formation serves as a signal amplification mechanism for inflammasomes. Nature Communications, 7. p. 11929.

Broz, Petr. (2016) Immune Response: Intracellular pathogens under attack. eLife, 5. e14729.

Broz, Petr. (2016) Inflammasomes in Host Defense and Autoimmunity. Chimia, 70 (12). pp. 853-855.

Groß, Christina J. and Mishra, Ritu and Schneider, Katharina S. and Médard, Guillaume and Wettmarshausen, Jennifer and Dittlein, Daniela C. and Shi, Hexin and Gorka, Oliver and Koenig, Paul-Albert and Fromm, Stephan and Magnani, Giovanni and Ćiković, Tamara and Hartjes, Lara and Smollich, Joachim and Robertson, Avril A. B. and Cooper, Matthew A. and Schmidt-Supprian, Marc and Schuster, Michael and Schroder, Kate and Broz, Petr and Traidl-Hoffmann, Claudia and Beutler, Bruce and Kuster, Bernhard and Ruland, Jürgen and Schneider, Sabine and Perocchi, Fabiana and Groß, Olaf. (2016) K(+) Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. Immunity, 45 (4). pp. 761-773.

Ravotti, Francesco and Sborgi, Lorenzo and Cadalbert, Riccardo and Huber, Matthias and Mazur, Adam and Broz, Petr and Hiller, Sebastian and Meier, Beat H. and Böckmann, Anja. (2016) Sequence-specific solid-state NMR assignments of the mouse ASC PYRIN domain in its filament form. Biomolecular NMR Assignments, 10 (1). pp. 107-115.

Rühl, Sebastian and Broz, Petr. (2016) The gasdermin-D pore: Executor of pyroptotic cell death. Oncotarget, 7 (36). pp. 57481-57482.

December 2015

Broz, Petr. (2015) Inflammasome assembly: the wheels are turning. Cell research, 25 (12). pp. 1277-1278.

29 October 2015

Broz, Petr. (2015) Immunology: Caspase target drives pyroptosis. Nature, 526. pp. 642-643.

27 October 2015

Sborgi, Lorenzo and Ravotti, Francesco and Dandey, Venkata Prasad and Dick, Mathias S. and Mazur, Adam and Reckel, Sina and Chami, Mohamed and Scherer, Sebastian and Huber, Matthias and Böckmann, Anja and Egelman, Edward H. and Stahlberg, Henning and Broz, Petr and Meier, Beat H. and Hiller, Sebastian. (2015) Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy. Proceedings of the National Academy of Sciences of the United States of America, 112 (43). pp. 13237-13242.

October 2015

Rühl, Sebastian and Broz, Petr. (2015) Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+ efflux. European journal of immunology, 45 (10). pp. 2927-2936.

2015

Meunier, Etienne and Wallet, Pierre and Dreier, Roland F. and Costanzo, Stéphanie and Anton, Leonie and Rühl, Sebastian and Dussurgey, Sébastien and Dick, Mathias S. and Kistner, Anne and Rigard, Mélanie and Degrandi, Daniel and Pfeffer, Klaus and Yamamoto, Masahiro and Henry, Thomas and Broz, Petr. (2015) Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. Nature immunology, Vol. 16, H. 5. pp. 476-484.

Meunier, Etienne and Broz, Petr. (2015) Interferon-induced guanylate-binding proteins promote cytosolic lipopolysaccharide detection by caspase-11. DNA and cell biology, Vol. 34, H. 1. pp. 1-5.

Meunier, Etienne and Broz, Petr. (2015) Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization. Journal of visualized experiments, H. 101 , e52960.

2014

Meunier, Etienne and Dick, Mathias S. and Dreier, Roland F. and Schürmann, Nura and Kenzelmann Broz, Daniela and Warming, Søren and Roose-Girma, Merone and Bumann, Dirk and Kayagaki, Nobuhiko and Takeda, Kiyoshi and Yamamoto, Masahiro and Broz, Petr. (2014) Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature, 509 (7500). pp. 366-370.

Broz, Petr. (2014) Getting rid of the bad apple : inflammasome-induced extrusion of salmonella-infected enterocytes. Cell host & microbe, Vol. 16, H. 2. pp. 153-155.

O'Donnell, Hope and Pham, Oanh H. and Li, Lin-Xi and Atif, Shaikh M. and Lee, Seung-Joo and Ravesloot, Marietta M. and Stolfi, Jessica L. and Nuccio, Sean-Paul and Broz, Petr and Monack, Denise M. and Baumler, Andreas J. and McSorley, Stephen J.. (2014) Toll-like Receptor and Inflammasome Signals Converge to Amplify the Innate Bactericidal Capacity of T Helper 1 Cells. Immunity, Vol. 40, H. 2. pp. 213-224.

2013

Xiao, Junpeng and Broz, Petr and Puri, Aaron W. and Deu, Edgar and Morell, Montse and Monack, Denise M. and Bogyo, Matthew. (2013) A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases. Journal of the American Chemical Society, Vol. 135, H. 24. pp. 9130-9138.

Broz, Petr and Monack, Denise M.. (2013) Measuring Inflammasome Activation in Response to Bacterial Infection. Methods in Molecular Biology, 1040. pp. 65-84.

Broz, Petr and Monack, Denise M.. (2013) Newly described pattern recognition receptors team up against intracellular pathogens. Nature reviews. Immunology, Vol. 13, H. 8. pp. 551-652.

Broz, Petr and Monack, Denise M.. (2013) Noncanonical inflammasomes: caspase-11 activation and effector mechanisms. PLoS Pathogens, 9 (2). e1003144.

2012

Puri, Aaron W. and Broz, Petr and Shen, Aimee and Monack, Denise M. and Bogyo, Matthew. (2012) Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection. Nature Chemical Biology, 8 (9). pp. 745-747.

Broz, Petr and Ruby, Thomas and Belhocine, Kamila and Bouley, Donna M. and Kayagaki, Nobuhiko and Dixit, Vishva M. and Monack, Denise M.. (2012) Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature, 490 (7419). pp. 288-291.

Broz, Petr and Ohlson, Maikke B. and Monack, Denise M.. (2012) Innate immune response to Salmonella typhimurium, a model enteric pathogen. Gut microbes, 3 (2). pp. 62-70.

2011

Peng, Kaitian and Broz, Petr and Jones, Jonathan and Joubert, Lydia-Marie and Monack, Denise. (2011) Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis. Cellular Microbiology, 13 (10). pp. 1586-1600.

Jones, Jonathan Wiley and Broz, Petr and Monack, Denise M.. (2011) Innate immune recognition of francisella tularensis: activation of type-I interferons and the inflammasome. Frontiers in Microbiology, 2. p. 16.

Broz, Petr and Monack, Denise M.. (2011) Molecular mechanisms of inflammasome activation during microbial infections. Immunological Reviews, 243 (1). pp. 174-190.

2010

Jones, Jonathan W. and Kayagaki, Nobuhiko and Broz, Petr and Henry, Thomas and Newton, Kim and O'Rourke, Karen and Chan, Salina and Dong, Jennifer and Qu, Yan and Roose-Girma, Meron and Dixit, Vishva M. and Monack, Denise M.. (2010) Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proceedings of the National Academy of Sciences, 107 (21). pp. 9771-9776.

Broz, Petr and von Moltke, Jakob and Jones, Jonathan W. and Vance, Russell E. and Monack, Denise M.. (2010) Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host & Microbe, 8 (6). pp. 471-483.

Broz, Petr and Newton, Kim and Lamkanfi, Mohamed and Mariathasan, Sanjeev and Dixit, Vishva M. and Monack, Denise M.. (2010) Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. Journal of Experimental Medicine, 207 (8). pp. 1745-1755.

2006

Broz, Petr. Functional and structural analysis of the "Yersinia enterocolitica" type III secretion translocon. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Mueller, Catherine A. and Broz, Petr and Cornelis, Guy R. and Müller, Shirley A. and Engel, Andreas. (2006) Type III secretion how Yersinia pestis infects its host. BIOforum Europe, Vol. 10, no. 4. pp. 40-42.

2003

Journet, Laure and Agrain, Céline and Broz, Petr and Cornelis, Guy R.. (2003) The needle length of bacterial injectisomes is determined by a molecular ruler. Science, 302, No. 5651. pp. 1757-1760.