Items where Author is "Bohnacker, Thomas"

2020

Borsari, Chiara and Keles, Erhan and Rageot, Denise and Treyer, Andrea and Bohnacker, Thomas and Bissegger, Lukas and De Pascale, Martina and Melone, Anna and Sriramaratnam, Rohitha and Beaufils, Florent and Hamburger, Matthias and Hebeisen, Paul and Löscher, Wolfgang and Fabbro, Doriano and Hillmann, Petra and Wymann, Matthias P.. (2020) 4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a potent, orally available, and brain-penetrant mTOR inhibitor for the treatment of neurological disorders. Journal of Medicinal Chemistry, 63 (22). pp. 13595-13617.

2017

Beaufils, Florent and Cmiljanovic, Natasa and Cmiljanovic, Vladimir and Bohnacker, Thomas and Melone, Anna and Marone, Romina and Jackson, Eileen and Zhang, Xuxiao and Sele, Alexander and Borsari, Chiara and Mestan, Jurgen and Hebeisen, Paul and Hillmann, Petra and Giese, Bernd and Zvelebil, Marketa and Fabbro, Doriano and Williams, Roger L. and Rageot, Denise and Wymann, Matthias P.. (2017) 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. Journal of Medicinal Chemistry, 60 (17). pp. 7524-7538.

Bohnacker, Thomas and Prota, Andrea E. and Beaufils, Florent and Burke, John E. and Melone, Anna and Inglis, Alison J. and Rageot, Denise and Sele, Alexander M. and Cmiljanovic, Vladimir and Cmiljanovic, Natasa and Bargsten, Katja and Aher, Amol and Akhmanova, Anna and Fernando Diaz, J. and Fabbro, Doriano and Zvelebil, Marketa and Williams, Roger L. and Steinmetz, Michel O. and Wymann, Matthias P.. (2017) Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nature communications, 8. p. 14683.

2016

Sele, Alexander M. and Rageot, Denise and Bohnacker, Thomas and Beaufils, Florent and Prota, Andrea E. and Steinmetz, Michel O. and Wymann, Matthias P.. (2016) Novel 4-(pyrimidin-2-yl)morpholines targeting the colchicine-binding site of tubulin. Cancer Research, 76 (14). p. 1364.

2015

Bohnacker, Thomas and Beaufils, Florent and Prota, Andrea E. and Burke, John E. and Melone, Anna and Inglis, Alison J. and Fusco, Ludovico and Cmiljanovic, Vladimir and Cmiljanovic, Natasa and Rageot, Denise and Bargsten, Katja and Saez-Calvo, Gonzalo and Pertz, Olivier and Aher, Amol B. and Akhmanova, Anna and Diaz, Fernando J. and Fabbro, Doriano and Zvelebil, Marketa and Williams, Roger L. and Steinmetz, Michel O. and Wymann, Matthias P.. (2015) BKM120-mediated G2 arrest: Structural and functional segregation of off-target action and PI3K inhibition. Cancer Research, 75 (15). p. 671.

Cmiljanovic, Vladimir and Ettlin, Robert A. and Beautils, Florent and Dieterle, Walter and Hillmann, Petra and Mestan, Juergen and Melone, Anna and Bohnacker, Thomas and Lang, Marc and Cmiljanovic, Natasa and Giese, Bernd and Hebeisen, Paul and Wymann, Matthias P. and Fabbro, Doriano. (2015) PQR309: A potent, brain-penetrant, dual pan-PI3K/mTOR inhibitor with excellent oral bioavailability and tolerability. Cancer Research, 75 (15). p. 4514.

Cmiljanovic, Vladimir and Cmiljanovic, Natasa and Marone, Romina and Beaufils, Florent and Zhang, Xuxiao and Zvelebil, Marketa and Hebeisen, Paul and Lang, Marc and Mestan, Juergen and Melone, Anna and Bohnacker, Thomas and Gaudio, Eugenio and Tarantelli, Chiara and Bertoni, Francesco and Ritschard, Reto and Pretre, Vincent and Wicki, Andreas and Fabbro, Doriano and Hillmann, Petra and Williams, Roger and Giese, Bernd and Wymann, Matthias P.. (2015) PQR309: Structure-based design, synthesis and biological evaluation of a novel, selective, dual pan-PI3K/mTOR inhibitor. Cancer Research, 75 (15). p. 2664.

Tarantelli, Chiara and Gaudio, Eugenio and Kwee, Ivo and Rinaldi, Andrea and Bernasconi, Elena and Cascione, Luciano and Hillmann, Petra and Stathis, Anastasios and Carrassa, Laura and Broggini, Massimo and Stussi, Georg and Fabbro, Doriano and Beaufils, Florent and Melone, Anna and Bohnacker, Thomas and Wymann, Matthias P. and Wicki, Andreas and Zucca, Emanuele and Cmiljanovic, Vladimir and Bertoni, Francesco. (2015) Pre-clinical activity and mechanism of action of the novel dual PI3K/mTOR inhibitor PQR309 in B-cell lymphomas. Cancer Research, 75 (15). p. 2652.

2012

Anzinger, Joshua J. and Chang, Janet and Xu, Qing and Barthwal, Manoj K. and Bohnacker, Thomas and Wymann, Matthias P. and Kruth, Howard S.. (2012) Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3K?-dependent fluid-phase pinocytosis of native LDL. Journal of Lipid Research, 53 (1). pp. 34-42.

2009

Bohnacker, Thomas and Marone, Romina and Collmann, Emilie and Calvez, Ronan and Hirsch, Emilio and Wymann, Matthias P.. (2009) PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells. Science signaling : the signal transduction knowledge environment, Vol. 2 , ra27.

Bohnacker, Thomas. PI3Kγ adapter subunits in mast cells. 2009, Doctoral Thesis, University of Basel, Faculty of Science.

Kurig, Barbara and Shymanets, Aliaksei and Bohnacker, Thomas and Prajwal, and Brock, Carsten and Ahmadian, Mohammad Reza and Schaefer, Michael and Gohla, Antje and Harteneck, Christian and Wymann, Matthias P. and Jeanclos, Elisabeth and Nürnberg, Bernd. (2009) Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Proceedings of the National Academy of Sciences of the United States of America, Vol. 106. pp. 20312-20317.

Marone, Romina and Erhart, Dominik and Mertz, Ann C. and Bohnacker, Thomas and Schnell, Christian and Cmiljanovic, Vladimir and Stauffer, Frédéric and Garcia-Echeverria, Carlos and Giese, Bernd and Maira, Sauveur-Michel and Wymann, Matthias P.. (2009) Targeting melanoma with dual phosphoinosite 3-kinase/mammalian target of rapamycin inhibitors. Molecular Cancer Research, Vol. 7. pp. 601-613.