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Items where contributor is "Lamers, Christina"

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2017

Flesch, Daniel and Cheung, Sun-Yee and Schmidt, Jurema and Gabler, Matthias and Heitel, Pascal and Kramer, Jan and Kaiser, Astrid and Hartmann, Markus and Lindner, Mara and Lüddens-Dämgen, Kerstin and Heering, Jan and Lamers, Christina and Lüddens, Hartmut and Wurglics, Mario and Proschak, Ewgenij and Schubert-Zsilavecz, Manfred and Merk, Daniel. (2017) Nonacidic Farnesoid X Receptor Modulators. Journal of Medicinal Chemistry, 60 (16). pp. 7199-7205.

2016

Lamers, Christina and Merk, Daniel and Gabler, Matthias and Flesch, Daniel and Kaiser, Astrid and Schubert-Zsilavecz, Manfred. (2016) SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound. Future medicinal chemistry, 8 (2). pp. 133-148.

Blöcher, René and Lamers, Christina and Wittmann, Sandra K. and Merk, Daniel and Hartmann, Markus and Weizel, Lilia and Diehl, Olaf and Brüggerhoff, Astrid and Boß, Marcel and Kaiser, Astrid and Schader, Tim and Göbel, Tamara and Grundmann, Manuel and Angioni, Carlo and Heering, Jan and Geisslinger, Gerd and Wurglics, Mario and Kostenis, Evi and Brüne, Bernhard and Steinhilber, Dieter and Schubert-Zsilavecz, Manfred and Kahnt, Astrid S. and Proschak, Ewgenij. (2016) N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators. Journal of medicinal chemistry, 59 (1). pp. 61-81.

2015

Merk, Daniel and Lamers, Christina and Weber, Julia and Flesch, Daniel and Gabler, Matthias and Proschak, Ewgenij and Schubert-Zsilavecz, Manfred. (2015) Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands. Bioorganic & medicinal chemistry, 23 (3). pp. 499-514.

Flesch, Daniel and Ness, Julia and Lamers, Christina and Dehm, Friederike and Popella, Sven and Steri, Ramona and Ogorek, Isabella and Hieke, Martina and Dannhardt, Gerd and Werz, Oliver and Weggen, Sascha and Schubert-Zsilavecz, Manfred. (2015) SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease. Bioorganic and Medicinal Chemistry Letters, 25 (4). pp. 841-846.

2014

Reker, Daniel and Perna, Anna M. and Rodrigues, Tiago and Schneider, Petra and Reutlinger, Michael and Mönch, Bettina and Koeberle, Andreas and Lamers, Christina and Gabler, Matthias and Steinmetz, Heinrich and Müller, Rolf and Schubert-Zsilavecz, Manfred and Werz, Oliver and Schneider, Gisbert. (2014) Revealing the macromolecular targets of complex natural products. Nature Chemistry, 6 (12). pp. 1072-1078.

Lamers, Christina and Schubert-Zsilavecz, Manfred and Merk, Daniel. (2014) Medicinal chemistry and pharmacological effects of Farnesoid X Receptor (FXR) antagonists. Current Topics in Medicinal Chemistry, 14 (19). pp. 2188-2205.

Merk, Daniel and Lamers, Christina and Ahmad, Khalil and Carrasco Gomez, Roberto and Schneider, Gisbert and Steinhilber, Dieter and Schubert-Zsilavecz, Manfred. (2014) Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist. Journal of Medicinal Chemistry, 57 (19). pp. 8035-8055.

Hanke, Thomas and Lamers, Christina and Gomez, Roberto Carrasco and Schneider, Gisbert and Werz, Oliver and Schubert-Zsilavecz, Manfred. (2014) Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition. Bioorganic and Medicinal Chemistry Letters, 24 (16). pp. 3757-3763.

Lamers, Christina and Dittrich, Michaela and Steri, Ramona and Proschak, Ewgenij and Schubert-Zsilavecz, Manfred. (2014) Molecular determinants for improved activity at PPARα: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα. Bioorganic and Medicinal Chemistry Letters, 24 (16). pp. 4048-4052.

Merk, Daniel and Gabler, Matthias and Gomez, Roberto Carrasco and Flesch, Daniel and Hanke, Thomas and Kaiser, Astrid and Lamers, Christina and Werz, Oliver and Schneider, Gisbert and Schubert-Zsilavecz, Manfred. (2014) Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR). Bioorganic & medicinal chemistry, 22 (8). pp. 2447-2460.

2013

Flesch, Daniel and Merk, Daniel and Lamers, Christina and Schubert-Zsilavecz, Manfred. (2013) Novel prostaglandin receptor modulators - part II: EP receptor modulators; a patent review (2002 - 2012). Expert opinion on therapeutic patents, 23 (2). pp. 233-267.

Lamers, Christina and Flesch, Daniel and Schubert-Zsilavecz, Manfred and Merk, Daniel. (2013) Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators. Expert opinion on therapeutic patents, 23 (1). pp. 47-77.

2012

la Buscató, Estel and Blöcher, René and Lamers, Christina and Klingler, Franca-Maria and Hahn, Steffen and Steinhilber, Dieter and Schubert-Zsilavecz, Manfred and Proschak, Ewgenij. (2012) Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors. Journal of Medicinal Chemistry, 55 (23). pp. 10771-10775.

Lamers, Christina and Schubert-Zsilavecz, Manfred and Merk, Daniel. (2012) Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008-present). Expert opinion on therapeutic patents, 22 (7). pp. 803-841.

2011

Lamers, Christina and Schubert-Zsilavecz, Manfred. (2011) Medizinische Chemie der β2‐Sympathomimetika. Erfolge in der Rezeptor‐Strukturaufklärung. Pharmazie in unserer Zeit, 40 (5). pp. 423-428.