2022
Frei, Irina Céline.
Role of adipose mTORC2 in mature adipocytes
and whole-body energy homeostasis.
2022,
Doctoral Thesis, University of Basel,
Faculty of Science.
Wälchli, Matthias.
Controlling the master - molecular mechanisms of mTOR regulation.
2022,
Doctoral Thesis, University of Basel,
Faculty of Science.
2021
Garofoli, Andrea.
Computational approaches to improve precision oncology.
2021,
Doctoral Thesis, University of Basel,
Faculty of Science.
Gao, Ruize.
Molecular mechanisms of therapy resistance in HCC:
USP29-mediated HIF1a stabilization promotes Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis and YAP/TAZ and ATF4 collaboratively drive resistance to Sorafenib therapy in hepatocellular carcinoma by preventing ferroptosis.
2021,
Doctoral Thesis, University of Basel,
Faculty of Science.
2019
Amante, Romain.
SHP2 blockade sensitizes triple negative breast cancers to PI3K inhibition leading to metastatic shrinkage.
2019,
Doctoral Thesis, University of Basel,
Faculty of Science.
2017
Habacher, Cornelia.
An auto-regulatory module controls fat metabolism in "Caenorhabditis elegans".
2017,
Doctoral Thesis, University of Basel,
Faculty of Science.
Prêtre, Vincent.
From the regulatory role of PDPN in mTOR/PI3K/Akt signaling to clinical trials.
2017,
Doctoral Thesis, University of Basel,
Faculty of Science.
Viganò, Cristina.
Quantitative proteomic and phospho-proteomic analysis of human DLD1 cells differing in ploidy and chromosome stability.
2017,
Doctoral Thesis, University of Basel,
Faculty of Science.
2016
Guri, Yakir.
mTORC2 promotes tumor growth via lipid synthesis.
2016,
Doctoral Thesis, University of Basel,
Faculty of Science.
Boldanova, Tujana.
Hepatitis C: transcriptional response and interferon signalling in human liver.
2016,
Doctoral Thesis, University of Basel,
Faculty of Science.
2015
Albert, Verena.
The role of hypothalamic mTORC1 and adipose tissue mTORC2 in organismal energetics.
2015,
Doctoral Thesis, University of Basel,
Faculty of Science.
Stracka, Daniele.
Upstream regulation of yeast TOR complexes.
2015,
Doctoral Thesis, University of Basel,
Faculty of Science.
Vanella, Rosario.
Yeast-based strategy for identification of 11β-HSD1 inhibitors.
2015,
Doctoral Thesis, University of Basel,
Faculty of Science.
2014
Tang, Fengyuan.
Expanding the Hippo pathway : hMOB3 modulates apoptotic MST1 signaling and supports tumor growth in glioblastoma.
2014,
Doctoral Thesis, University of Basel,
Faculty of Science.
Keglowich, Laura Franziska.
Airway wall remodeling in asthma : novel mechanisms of human bronchial smooth muscle cells in the induction of angiogenesis.
2014,
Doctoral Thesis, University of Basel,
Faculty of Science.
2013
Shende, Pankaj.
Dissecting the roles of mTORC1 and mTORC2 in the mouse heart.
2013,
Doctoral Thesis, University of Basel,
Faculty of Science.
Schultze, Simon Manuel.
The role of systemically perturbed PTEN and PKBß/AKT2 signaling in accumulation of hepatic lipids.
2013,
Doctoral Thesis, University of Basel,
Faculty of Science.
Schlatter, Ivan.
Functional analysis of "MEMO / MHO1", an evolutionary conserved gene, in yeast and mammalian cells.
2013,
Doctoral Thesis, University of Basel,
Faculty of Science.
2012
Robitaille, Aaron M..
Quantitative phosphoproteomics reveal that mTOR regulates cell growth and proliferation by phosphorylating a functionally diverse set of substrates.
2012,
Doctoral Thesis, University of Basel,
Faculty of Science.
Betz, Charles.
mTOR complex 2 - akt signaling is physically and functionally at mam.
2012,
Doctoral Thesis, University of Basel,
Faculty of Science.
Cremonesi, Alessio.
Characterization of the yeast rapamycin-sensitive phosphoproteome.
2012,
Doctoral Thesis, University of Basel,
Faculty of Science.
2011
Schmitz-Rohmer, Debora.
Mammalian NDR kinases : tumor suppressors with essential functions in embryonic development.
2011,
Doctoral Thesis, University of Basel,
Faculty of Science.
2010
Cybulski, Nadine.
New insights into the "in vivo" and "in vitro" functions of mammalian TOR complex 2.
2010,
Doctoral Thesis, University of Basel,
Faculty of Science.
2009
Kalender, Adem.
Regulation of the mTOR/S6K pathway by cellular energy.
2009,
Doctoral Thesis, University of Basel,
Faculty of Science.
Fan, Xiucheng.
Investigation of quantitative and qualitative MtDNA alteration in breast cancer.
2009,
Doctoral Thesis, University of Basel,
Faculty of Science.
2008
Polak, Pazit.
Regulation of adipogenesis and adipose maintenance by the mammalian TOR complex 1.
2008,
Doctoral Thesis, University of Basel,
Faculty of Science.
Christen, Verena.
Interferon alpha signaling in viral hepatitis.
2008,
Doctoral Thesis, University of Basel,
Faculty of Science.
Necker, Judith.
Hereditary colorectal cancer : assessment of genotype-phenotype correlations and analysis of rare susceptibility genes in familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC).
2008,
Doctoral Thesis, University of Basel,
Faculty of Science.
Bucher, Rainer Michael.
Structural insights into the basis and evolution of interactions in multi-subunit protein assemblies. tryptophan synthase and titin FNIII-repeats.
2008,
Doctoral Thesis, University of Basel,
Faculty of Science.
2007
Emter, Roger.
Functional dissection of the C-terminal part of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator alpha (PGC-1[alpha]).
2007,
Doctoral Thesis, University of Basel,
Faculty of Science.
Gander, Stefan.
Functional analysis of the "Saccharomyces cerevisiae" Npr1 protein kinase.
2007,
Doctoral Thesis, University of Basel,
Faculty of Science.
Anastasiou, Dimitrios.
Identification of novel mechanisms regulating the NAD+ -dependent deacetylase SIRT1.
2007,
Doctoral Thesis, University of Basel,
Faculty of Science.
Rhomberg, Thomas Alexander.
Molecular and cellular basis of the internalization of "Bartonella henselae" by human endothelial cells.
2007,
Doctoral Thesis, University of Basel,
Faculty of Science.
2006
Di Cara, Alessandro.
Disruption of ribosome biogenesis triggers a p21/p53-mediated cell cycle checkpoint.
2006,
Doctoral Thesis, University of Basel,
Faculty of Science.
Guye-Vuillème, Patrick.
Proteins injected by the bacterial pathogen "Bartonella" subvert eukaryotic cell signaling.
2006,
Doctoral Thesis, University of Basel,
Faculty of Science.
Shioda, Ryo.
Functional analysis of TOR complex 2 and its control of sphingolipid biosynthesis in "Saccharomyces cerevisiae".
2006,
Doctoral Thesis, University of Basel,
Faculty of Science.
Molle, Klaus-Dieter.
Regulation of the mammalian target of rapamycin complex 2 (mTORC2).
2006,
Doctoral Thesis, University of Basel,
Faculty of Science.
2005
Li, Weimin.
Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization.
2005,
Doctoral Thesis, University of Basel,
Faculty of Science.
Meier, Karsten D..
Mechanisms of sphingolipid functions during heat stress in "Saccharomyces cerevisiae".
2005,
Doctoral Thesis, University of Basel,
Faculty of Science.
Zamurovic, Natasa.
Transcriptional program of osteoblast differentiation : coordinated activation of Notch, Wnt, and TGF-[beta] signaling pathways in MC3T3 cell line.
2005,
Doctoral Thesis, University of Basel,
Faculty of Science.
Schmidlin-Stalder, Martin.
Regulation of mRNA stability via BRF1 and other AU-binding proteins.
2005,
Doctoral Thesis, University of Basel,
Faculty of Science.
2004
Schmidt, Karsten.
Analysis of the structure and function of protein phosphatase 2A.
2004,
Doctoral Thesis, University of Basel,
Faculty of Science.
Morales-Johansson, Helena.
Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae".
2004,
Doctoral Thesis, University of Basel,
Faculty of Science.
Um, Sung Hee.
The role of S6K1 in development and maintenance of nutrient homeostasis.
2004,
Doctoral Thesis, University of Basel,
Faculty of Science.
Schreiber, Sylvia Nicole.
The transcriptional coactivator PGC-1[alpha] as a modulator of ERR[alpha] and GR signaling : function in mitochondrial biogenesis.
2004,
Doctoral Thesis, University of Basel,
Faculty of Science.
Leuenberger, Sabrina Angélique.
On the role of ras and BRF1 in the regulation of ARE-dependent mRNA-turnover.
2004,
Doctoral Thesis, University of Basel,
Faculty of Science.
Wullschleger, Stephan.
Characterization of TOR complex 2 (TORC2) in "Saccharomyces cerevisiae".
2004,
Doctoral Thesis, University of Basel,
Faculty of Science.
2001
Lombardi, Ruben.
Molecular dissection of the internalization step of endocytosis in "Saccharomyces cerevisiae" : Rvs167p and binding partners.
2001,
Doctoral Thesis, University of Basel,
Faculty of Science.
