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Patrick Vizeli, Matthias E. Liechti
Oxytocin receptor gene variations and socio-emotional effects of MDMA: A pooled analysis of controlled studies in healthy subjects
www.plosone.org
www.plosone.org
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10 0 0 10 200.0125 587.2818 cm
BT
/F6 1 Tf
1 TL
-0.02 Tc
0 0 Td
(On)Tj
1.4796 0 Td
(the)Tj
1.423 0 Td
(VASs,)Tj
2.5795 0 Td
(MDMA)Tj
3.3619 0 Td
(increased)Tj
3.8608 0 Td
(the)Tj
1.4173 0 Td
(AUEC)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 367.1433 585.5811 cm
BT
/F6 1 Tf
1 TL
-0.0266 Tc
0 0 Td
(6)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 372.7559 587.2818 cm
BT
/F6 1 Tf
1 TL
-0.02 Tc
0 0 Td
(values)Tj
2.5681 0 Td
(for)Tj
1.338 0 Td
(any)Tj
1.9899 0 Td
(drug)Tj
2.0466 0 Td
(effect)Tj
2.6419 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 486.8787 585.5811 cm
BT
/F6 1 Tf
1 TL
-0.0266 Tc
0 0 Td
(1,131)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 504.17 587.2818 cm
BT
/F6 1 Tf
1 TL
-0.02 Tc
0 0 Td
(=)Tj
0.788 0 Td
(544,)Tj
/F11 1 Tf
1.8085 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6746 0 Td
(<)Tj
/F6 1 Tf
-0.02 Tc
0.9921 0 Td
(0.001\),)Tj
-34.6787 -1.3039 Td
(closeness)Tj
4.4844 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 253.0771 572.5984 cm
BT
/F6 1 Tf
1 TL
-0.0266 Tc
0 0 Td
(1,131)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 270.4251 574.2425 cm
BT
/F6 1 Tf
1 TL
-0.02 Tc
0 0 Td
(=)Tj
0.7823 0 Td
(57,)Tj
/F11 1 Tf
1.3493 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6803 0 Td
(<)Tj
/F6 1 Tf
-0.02 Tc
0.9865 0 Td
(0.001\),)Tj
2.8062 0 Td
(trust)Tj
2.7496 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 372.1889 572.5984 cm
BT
/F6 1 Tf
1 TL
-0.0266 Tc
0 0 Td
(1,52)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 386.1354 574.2425 cm
BT
/F6 1 Tf
1 TL
-0.02 Tc
0 0 Td
(=)Tj
0.7823 0 Td
(33;)Tj
/F11 1 Tf
1.3493 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6803 0 Td
(<)Tj
/F6 1 Tf
-0.02 Tc
0.9921 0 Td
(0.001\),)Tj
2.8006 0 Td
(want)Tj
2.4945 0 Td
(to)Tj
0.9921 0 Td
(be)Tj
1.1225 0 Td
(hugged)Tj
3.4356 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 540.907 572.5984 cm
BT
/F6 1 Tf
1 TL
-0.0266 Tc
0 0 Td
(1,52)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 554.7968 574.2425 cm
BT
/F6 1 Tf
1 TL
-0.02 Tc
0 0 Td
(=)Tj
-35.4782 -1.2982 Td
(6.6,)Tj
/F11 1 Tf
1.5591 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6746 0 Td
(<)Tj
/F6 1 Tf
-0.02 Tc
0.9922 0 Td
(0.05\),)Tj
2.3414 0 Td
(want)Tj
2.5001 0 Td
(to)Tj
0.9921 0 Td
(hug)Tj
2.0693 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 319.5779 559.6157 cm
BT
/F6 1 Tf
1 TL
-0.0266 Tc
0 0 Td
(1,52)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 333.4677 561.2598 cm
BT
/F6 1 Tf
1 TL
-0.02 Tc
0 0 Td
(=)Tj
0.7823 0 Td
(7.6,)Tj
/F11 1 Tf
1.5591 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6803 0 Td
(<)Tj
/F6 1 Tf
-0.02 Tc
0.9921 0 Td
(0.01\),)Tj
2.3414 0 Td
(and)Tj
1.6838 0 Td
(want)Tj
2.4944 0 Td
(to)Tj
0.9921 0 Td
(be)Tj
1.1226 0 Td
(with)Tj
1.9332 0 Td
(others)Tj
2.9877 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 517.4362 559.6157 cm
BT
/F6 1 Tf
1 TL
-0.0266 Tc
0 0 Td
(1,52)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 531.3259 561.2598 cm
BT
/F6 1 Tf
1 TL
-0.02 Tc
0 0 Td
(=)Tj
0.7823 0 Td
(20,)Tj
/F11 1 Tf
-33.9134 -1.2982 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6803 0 Td
(<)Tj
/F6 1 Tf
-0.02 Tc
0.9922 0 Td
(0.001\))Tj
2.5908 0 Td
(and)Tj
1.6838 0 Td
(decreased)Tj
3.9911 0 Td
(feelings)Tj
3.1124 0 Td
(of)Tj
0.9808 0 Td
(want)Tj
2.5002 0 Td
(to)Tj
0.9921 0 Td
(be)Tj
1.1168 0 Td
(alone)Tj
2.6759 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 421.4551 546.5763 cm
BT
/F6 1 Tf
1 TL
-0.0266 Tc
0 0 Td
(1,52)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 435.3448 548.2771 cm
BT
/F6 1 Tf
1 TL
-0.02 Tc
0 0 Td
(=)Tj
0.788 0 Td
(21,)Tj
/F11 1 Tf
1.3493 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6746 0 Td
(<)Tj
/F6 1 Tf
-0.02 Tc
0.9921 0 Td
(0.001,)Tj
0.83 0.64 0.02 0 k
2.4775 0 Td
(Fig)Tj
1.4343 0 Td
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.8901 0 Td
(Table)Tj
2.3584 0 Td
(1)Tj
0 g
(\).)Tj
-0.004 Tc
-33.3011 -1.3039 Td
(The)Tj
1.7858 0 Td
(effects)Tj
2.7269 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(OXTR)Tj
/F11 1 Tf
2.8517 0 Td
[()5( \n)]TJ
/F6 1 Tf
4.1669 0 Td
(SNP)Tj
1.9899 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(subjective)Tj
4.1668 0 Td
(effects)Tj
2.7213 0 Td
(of)Tj
1.0148 0 Td
(MDMA)Tj
3.4299 0 Td
(are)Tj
1.4456 0 Td
(shown)Tj
2.8516 0 Td
(in)Tj
0.83 0.64 0.02 0 k
-35.5744 -1.2982 Td
(Table)Tj
2.4377 0 Td
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9241 0 Td
(Fig)Tj
1.4797 0 Td
(1)Tj
0 g
(,)Tj
0.9184 0 Td
(and)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(S1)Tj
1.1679 0 Td
(Table)Tj
0 g
(.)Tj
2.6702 0 Td
(MDMA)Tj
3.4242 0 Td
(produced)Tj
4.0479 0 Td
(increases)Tj
3.8324 0 Td
(in)Tj
1.0317 0 Td
(trust)Tj
2.863 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 473.896 520.611 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1,49)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 488.4661 522.2551 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(=)Tj
0.7993 0 Td
(14,)Tj
/F11 1 Tf
1.3947 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6973 0 Td
(<)Tj
/F6 1 Tf
-0.004 Tc
0.9921 0 Td
(0.001\),)Tj
-32.7285 -1.2982 Td
(want)Tj
2.5738 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(hugged)Tj
3.549 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 291.5716 507.5716 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1,49)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 306.1417 509.2724 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(=)Tj
0.7993 0 Td
(5.3,)Tj
/F11 1 Tf
1.6214 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6973 0 Td
(<)Tj
/F6 1 Tf
-0.004 Tc
0.9922 0 Td
(0.05\),)Tj
2.4377 0 Td
(and)Tj
1.7292 0 Td
(want)Tj
2.5795 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1452 0 Td
(with)Tj
2.0012 0 Td
(others)Tj
3.1011 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 496.0062 507.5716 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1,49)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 510.5763 509.2724 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(=)Tj
0.7993 0 Td
(6.5,)Tj
/F11 1 Tf
1.6214 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6973 0 Td
(<)Tj
/F6 1 Tf
-0.004 Tc
0.9865 0 Td
(0.05\))Tj
-35.1606 -1.2982 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(TT)Tj
1.44 0 Td
(genotype)Tj
3.8607 0 Td
(group)Tj
2.6079 0 Td
(compared)Tj
4.2406 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
1.4684 0 Td
(G)Tj
0.9354 0 Td
(allele)Tj
2.2394 0 Td
(carriers.)Tj
3.4695 0 Td
(MDMA)Tj
3.4243 0 Td
(lowered)Tj
3.4014 0 Td
(ratings)Tj
2.965 0 Td
(of)Tj
-34.5596 -1.3039 Td
(wanting)Tj
3.8551 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(alone)Tj
2.7722 0 Td
(more)Tj
2.3414 0 Td
(in)Tj
1.0375 0 Td
(subjects)Tj
3.3789 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(TT)Tj
1.44 0 Td
(genotype)Tj
3.8607 0 Td
(compared)Tj
4.2463 0 Td
(with)Tj
1.9956 0 Td
(G)Tj
0.9353 0 Td
(allele)Tj
2.2394 0 Td
(carriers)Tj
-33.7433 -1.2983 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 208.5732 468.6236 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1,49)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 223.1433 470.2677 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(=)Tj
0.7993 0 Td
(4.5,)Tj
/F11 1 Tf
1.6214 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6973 0 Td
(<)Tj
/F6 1 Tf
-0.004 Tc
0.9865 0 Td
(0.05\).)Tj
2.4378 0 Td
(Using)Tj
2.6022 0 Td
(Nyholt)Tj
2.9877 0 Td
(correction)Tj
4.3596 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(multiple)Tj
3.566 0 Td
(comparisons,)Tj
5.5615 0 Td
(only)Tj
1.9786 0 Td
(MDMA)Tj
-32.7682 -1.2982 Td
(effects)Tj
2.7268 0 Td
(on)Tj
1.2756 0 Td
(trust)Tj
2.8573 0 Td
(was)Tj
1.7008 0 Td
(significantly)Tj
5.091 0 Td
(altered)Tj
2.9423 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
/F11 1 Tf
1.474 0 Td
[()5( \n)]TJ
/F6 1 Tf
4.1669 0 Td
(SNP.)Tj
2.2167 0 Td
(The)Tj
1.7801 0 Td
(OXTR)Tj
/F11 1 Tf
2.8517 0 Td
[()5()]TJ
/F6 1 Tf
3.2371 0 Td
(and)Tj
/F11 1 Tf
-33.4995 -1.3039 Td
[()5(\n\n \n)]TJ
/F6 1 Tf
4.1668 0 Td
(SNPs)Tj
2.3527 0 Td
(did)Tj
1.5421 0 Td
(not)Tj
1.5704 0 Td
(alter)Tj
1.9955 0 Td
(the)Tj
1.4684 0 Td
(subjective)Tj
4.1612 0 Td
(effects)Tj
2.7269 0 Td
(of)Tj
1.0148 0 Td
(MDMA)Tj
3.4299 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.778 0 Td
(1)Tj
0 g
(\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 416.4661 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Emotion)Tj
3.8598 0 Td
(recognition)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 399.4582 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(On)Tj
1.5136 0 Td
(the)Tj
1.4684 0 Td
(FERT,)Tj
2.7779 0 Td
(MDMA)Tj
3.4242 0 Td
(impaired)Tj
3.8495 0 Td
(the)Tj
1.4683 0 Td
(recognition)Tj
4.8472 0 Td
(of)Tj
1.0148 0 Td
(fearful)Tj
2.8006 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 440.2204 397.7574 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1,68)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 454.7905 399.4582 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(=)Tj
0.7993 0 Td
(47,)Tj
/F11 1 Tf
1.3947 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6973 0 Td
(<)Tj
/F6 1 Tf
-0.004 Tc
0.9921 0 Td
(0.001\),)Tj
2.9083 0 Td
(sad)Tj
1.5477 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 546.7464 397.7574 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1,68)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 561.3165 399.4582 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(=)Tj
-36.1301 -1.2982 Td
(14,)Tj
/F11 1 Tf
1.3946 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6973 0 Td
(<)Tj
/F6 1 Tf
-0.004 Tc
0.9922 0 Td
(0.001\),)Tj
2.914 0 Td
(and)Tj
1.7291 0 Td
(angry)Tj
2.4945 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 310.7905 384.7748 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1,68)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 325.3606 386.4755 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(=)Tj
0.7993 0 Td
(16,)Tj
/F11 1 Tf
1.3947 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6973 0 Td
(<)Tj
/F6 1 Tf
-0.004 Tc
0.9921 0 Td
(0.001\))Tj
2.6872 0 Td
(faces)Tj
2.1487 0 Td
(compared)Tj
4.2462 0 Td
(with)Tj
1.9956 0 Td
(placebo.)Tj
3.5036 0 Td
(None)Tj
2.4321 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-34.4463 -1.3039 Td
(OXTR)Tj
2.8517 0 Td
(gene)Tj
2.0806 0 Td
(variants)Tj
3.3902 0 Td
(moderated)Tj
4.5523 0 Td
(the)Tj
1.4683 0 Td
(effects)Tj
2.727 0 Td
(of)Tj
1.0148 0 Td
(MDMA)Tj
3.4242 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(FERT.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 345.6566 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Empathy)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 328.6488 cm
BT
/F6 1 Tf
1 TL
-0.01 Tc
0 0 Td
(MDMA)Tj
3.4015 0 Td
(increased)Tj
3.9458 0 Td
(explicit)Tj
3.0784 0 Td
(emotional)Tj
4.2179 0 Td
(empathy)Tj
3.6567 0 Td
(for)Tj
1.3663 0 Td
(positive)Tj
3.2655 0 Td
(emotions)Tj
3.9061 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 476.844 326.948 cm
BT
/F6 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(1,68)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 491.1874 328.6488 cm
BT
/F6 1 Tf
1 TL
-0.01 Tc
0 0 Td
(=)Tj
0.7936 0 Td
(7.6,)Tj
/F11 1 Tf
1.5988 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.686 0 Td
(<)Tj
/F6 1 Tf
-0.01 Tc
0.9921 0 Td
(0.01\))Tj
2.1826 0 Td
(com-)Tj
-35.3703 -1.3039 Td
(pared)Tj
2.4604 0 Td
(with)Tj
1.9729 0 Td
(placebo.)Tj
3.4583 0 Td
(None)Tj
2.4094 0 Td
(of)Tj
1.0034 0 Td
(the)Tj
1.4514 0 Td
(OXTR)Tj
2.8289 0 Td
(gene)Tj
2.058 0 Td
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