Simplified deoxypropionate acyl chains for Mycobacterium tuberculosis sulfoglycolipid analogues : chain length is essential for high antigenicity

Prandi, Jacques

doi:10.1002/cbic.201300482

Simplified deoxypropionate acyl chains for Mycobacterium tuberculosis sulfoglycolipid analogues : chain length is essential for high antigenicity

Date Issued

2013-01-01

Author(s)

Gau, Benjamin

Lemétais, Aurélie

Lepore, Marco

Garcia-Alles, Luis Fernando

Bourdreux, Yann

Mori, Lucia

Gilleron, Martine

De Libero, Gennaro

Puzo, Germain

Beau, Jean-Marie

Prandi, Jacques

DOI

10.1002/cbic.201300482

Abstract

The longer, the better: Increasing the lengths of the 1,3-methyl-branched fatty acyl chain units in mycobacterial diacylated sulfoglycolipid (Acyl2 SGL) analogues led to dramatic improvements in their antigenic properties and gave products more potent than the natural antigen Acyl2 SGLs.