Phenol-based macrocycles play a fundamental role in supramolecular chemistry, but their size has been rather limited. Here we report a novel class of very large, bowl-shaped macrocycles with a diameter of 21.8 Å. These quinoacridane[4]arenes are 150% larger than the current record holders, the acridane[4]arenes, and three times the size of resorcin[4]arene. We expect the quinoacridane[4]arenes to be a useful platform for the construction of molecular containers.
