When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries : an observational study
Date Issued
2011-01-01
Author(s)
HIV-CAUSAL, Collaboration
Cain, Lauren E
Logan, Roger
Robins, James M
Sterne, Jonathan A C
Sabin, Caroline
Bansi, Loveleen
Justice, Amy
Goulet, Joseph
van Sighem, Ard
de Wolf, Frank
von Wyl, Viktor
Esteve, Anna
Casabona, Jordi
del Amo, Julia
Moreno, Santiago
Seng, Remonie
Meyer, Laurence
Perez-Hoyos, Santiago
Muga, Roberto
Lodi, Sara
Lanoy, Emilie
Costagliola, Dominique
Hernan, Miguel A
DOI
10.7326/0003-4819-154-8-201104190-00001
Abstract
Most clinical guidelines recommend that AIDS-free, HIV-infected persons with CD4 cell counts below 0.350 × 10(9) cells/L initiate combined antiretroviral therapy (cART), but the optimal CD4 cell count at which cART should be initiated remains a matter of debate.