Early and nonreversible decrease of CD161++/MAIT cells in HIV infection
Date Issued
2013-02-07
Author(s)
Cosgrove, Cormac
Ussher, James E.
Rauch, Andri
Gärtner, Kathleen
Kurioka, Ayako
Hühn, Michael H.
Adelmann, Krista
Kang, Yu-Hoi
Fergusson, Joannah R.
Simmonds, Peter
Goulder, Philip
Hansen, Ted H.
Fox, Julie
Günthard, Huldrych F.
Powrie, Fiona
Steel, Alan
Gazzard, Brian
Phillips, Rodney E.
Frater, John
Uhlig, Holm
Klenerman, Paul
DOI
10.1182/blood-2012-06-436436
Abstract
/MAIT cells are not preferentially infected but may be depleted through diverse mechanisms including accumulation in tissues and activation-induced cell death. This loss may impact mucosal defense and could be important in susceptibility to specific opportunistic infections in HIV. © 2013 by The American Society of Hematology.