Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

Böni-Schnetzler, M

doi:10.1007/s00125-010-1747-3

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

Date Issued

2010-01-01

Author(s)

Ehses, J A

Meier, D T

Wueest, S

Rytka, J

Boller, S

Wielinga, P Y

Schraenen, A

Lemaire, K

Debray, S

Van Lommel, L

Pospisilik, J A

Tschopp, O

Schultze, S M

Malipiero, U

Esterbauer, H

Ellingsgaard, H

Rütti, S

Schuit, F C

Lutz, T A

Böni-Schnetzler, M

Konrad, D

Donath, Marc Y

DOI

10.1007/s00125-010-1747-3

Abstract

Inflammation contributes to both insulin resistance and pancreatic beta cell failure in human type 2 diabetes. Toll-like receptors (TLRs) are highly conserved pattern recognition receptors that coordinate the innate inflammatory response to numerous substances, including NEFAs. Here we investigated a potential contribution of TLR2 to the metabolic dysregulation induced by high-fat diet (HFD) feeding in mice.