NeoPHOX - an easily accessible P,N ligand for Iridium-catalyzed asymmetric hydrogenation : preparation, scope and application in the synthesis of Demethyl Methoxycalamenene

Using a new class of chiral iridium hydrogenation catalysts, the antitumor natural product demethyl calamenene was synthesized in four steps in >20% overall yield and high enantiomeric purity.