IL-1 activation as a response to metabolic disturbances
Date Issued
2010-01-01
Author(s)
Boeni-Schnetzler, Marianne
DOI
10.1016/j.cmet.2010.10.002
Abstract
IL-1 is a major regulator of islet inflammation in type 2 diabetes. Several factors contribute to the induction of islet-derived IL-1 , including glucose, free fatty acids, and leptin. A recent report in Nature Immunology (Masters et al., 2010) identifies amyloid polypeptide as an additional enhancer of IL-1 production.