JP-45/JSRP1 Variants Affect Skeletal Muscle Excitation-Contraction Coupling by Decreasing the Sensitivity of the Dihydropyridine Receptor

Date Issued
2013-01-01
Author(s)
Yasuda, T.
Delbono, O.
Wang, Z. M.
Messi, M. L.
DOI
10.1002/humu.22209
Abstract
JP-45 (also JP45; encoded by JSRP1) is an integral protein constituent of the skeletal muscle sarcoplasmic reticulum junctional face membrane interacting with Ca(v) 1.1 (the alpha.1 subunit of the voltage-sensing dihydropyridine receptor, DHPR) and the luminal calcium-binding protein calsequestrin. Two JSRP1 variants have been found in the human population: c.323C
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