High specificity of line-immunoassay based algorithms for recent HIV-1 infection independent of viral subtype and stage of disease

Bucher, H C

doi:10.1186/1471-2334-11-254

High specificity of line-immunoassay based algorithms for recent HIV-1 infection independent of viral subtype and stage of disease

Date Issued

2011-01-01

Author(s)

Schüpbach, Jörg

Bisset, Leslie R

Regenass, Stephan

Bürgisser, Philippe

Gorgievski, Meri

Steffen, Ingrid

Andreutti, Corinne

Martinetti, Gladys

Shah, Cyril

Yerly, Sabine

Klimkait, Thomas

Gebhardt, Martin

Schöni-Affolter, Franziska

Rickenbach, Martin

Swiss, HIV Cohort Study

Barth, J

Battegay, M

Bernascon, E

Böni, J

Bucher, H C

Bürgisser, P

Burton-Jeangros, C

Calmy, A

Cavassini, M

Dubs, R

Egger, M

Elzi, L

Fehr, J

Fischer, M

Flepp, M

Francioli, P

Furrer, H

Fux, C A

Gorgievski, M

Günthard, H

Hasse, B

Hirsch, H H

Hirschel, B

Hösli, I

Kahlert, C

Kaiser, L

Keiser, O

Kind, C

Klimkait, T

Kovari, H

Ledergerber, B

Martinetti, G

Martinez de Tejada, B

Müller, N

Nadal, D

Pantaleo, G

Rauch, A

Regenass, S

Rickenbach, M

Rudin, C

Schmid, P

Schultze, D

Schöni-Affolter, F

Schüpbach, J

Speck, R

Taffé, P

Telenti, A

Trkola, A

Vernazza, P

von Wyl, V

Weber, R

Yerly, S

DOI

10.1186/1471-2334-11-254

Abstract

Serologic testing algorithms for recent HIV seroconversion (STARHS) provide important information for HIV surveillance. We have shown that a patient's antibody reaction in a confirmatory line immunoassay (INNO-LIA HIV I/II Score, Innogenetics) provides information on the duration of infection. Here, we sought to further investigate the diagnostic specificity of various Inno-Lia algorithms and to identify factors affecting it.

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