Common brain disorders are associated with heritable patterns of apparent aging of the brain
Date Issued
2019-01-01
Author(s)
Kaufmann, Tobias
van der Meer, Dennis
Doan, Nhat Trung
Schwarz, Emanuel
Lund, Martina J.
Agartz, Ingrid
Alnæs, Dag
Barch, Deanna M.
Baur-Streubel, Ramona
Bertolino, Alessandro
Bettella, Francesco
Beyer, Mona K.
Bøen, Erlend
Brandt, Christine L.
Buitelaar, Jan
Celius, Elisabeth G.
Cervenka, Simon
Conzelmann, Annette
Córdova-Palomera, Aldo
Dale, Anders M.
Di Carlo, Pasquale
Djurovic, Srdjan
Dørum, Erlend S.
Eisenacher, Sarah
Elvsåshagen, Torbjørn
Espeseth, Thomas
Fatouros-Bergman, Helena
Flyckt, Lena
Franke, Barbara
Frei, Oleksandr
Haatveit, Beathe
Håberg, Asta K.
Harbo, Hanne F.
Hartman, Catharina A.
Heslenfeld, Dirk
Hoekstra, Pieter J.
Høgestøl, Einar A.
Jernigan, Terry L.
Jonassen, Rune
Jönsson, Erik G.
Karolinska, Schizophrenia Project
Kirsch, Peter
Kłoszewska, Iwona
Kolskår, Knut K.
Landrø, Nils Inge
Le Hellard, Stephanie
Lesch, Klaus-Peter
Lovestone, Simon
Lundervold, Arvid
Lundervold, Astri J.
Maglanoc, Luigi A.
Malt, Ulrik F.
Mecocci, Patrizia
Melle, Ingrid
Meyer-Lindenberg, Andreas
Moberget, Torgeir
Norbom, Linn B.
Nordvik, Jan Egil
Nyberg, Lars
Oosterlaan, Jaap
Papalino, Marco
Pauli, Paul
Pergola, Giulio
Persson, Karin
Richard, Geneviève
Rokicki, Jaroslav
Sanders, Anne-Marthe
Selbæk, Geir
Shadrin, Alexey A.
Smeland, Olav B.
Soininen, Hilkka
Sowa, Piotr
Steen, Vidar M.
Tsolaki, Magda
Ulrichsen, Kristine M.
Vellas, Bruno
Wang, Lei
Westman, Eric
Ziegler, Georg C.
Zink, Mathias
Andreassen, Ole A.
Westlye, Lars T.
DOI
10.1038/s41593-019-0471-7
Abstract
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.