edoc

Thiohistidine biosynthesis

Seebeck, Florian. (2013) Thiohistidine biosynthesis. Chimia, 67 (5). pp. 333-336.

[img]
Preview
PDF - Published Version
181Kb

Official URL: http://edoc.unibas.ch/dok/A6223475

Downloads: Statistics Overview

Abstract

Ergothioneine and ovothiol A are sulfur-containing histidine derivatives produced by microorganisms including Mycobacterium tuberculosis, Trypanosoma cruzi or Erwinia amylovora and may also play important roles in human physiology. Based on our recent identification of thiohistidine biosynthetic enzymes from Mycobacterium smegmatis and Erwinia tasmaniensis we investigate several aspects of sulfur-based redox biochemistry. For example, we are characterizing the catalytic mechanism of two thiohistidine biosynthetic enzymes which afford O2-dependent sulfur insertion into the C(5)-H and C(2)-H bonds of the imidazolyl side chain of histidine.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck)
UniBasel Contributors:Seebeck, Florian Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Schweizerische Chemische Gesellschaft
ISSN:0009-4293
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
edoc DOI:
Last Modified:12 Apr 2017 09:41
Deposited On:27 Mar 2014 13:12

Repository Staff Only: item control page