edoc

Disparate Impact of Oxidative Host Defenses Determines the Fate of Salmonella during Systemic Infection in Mice

Burton, Neil A. and Schürmann, Nura and Casse, Olivier and Steeb, Anne K. and Claudi, Beatrice and Zankl, Janine and Schmidt, Alexander and Bumann, Dirk. (2014) Disparate Impact of Oxidative Host Defenses Determines the Fate of Salmonella during Systemic Infection in Mice. Cell Host & Microbe, 15 (1). pp. 72-83.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6223211

Downloads: Statistics Overview

Abstract

Reactive oxygen and nitrogen species function in host defense via mechanisms that remain controversial. Pathogens might encounter varying levels of these species, but bulk measurements cannot resolve such heterogeneity. We used single-cell approaches to determine the impact of oxidative and nitrosative stresses on individual Salmonella during early infection in mouse spleen. Salmonella encounter and respond to both stresses, but the levels and impact vary widely. Neutrophils and inflammatory monocytes kill Salmonella by generating overwhelming oxidative stress through NADPH oxidase and myeloperoxidase. This controls Salmonella within inflammatory lesions but does not prevent their spread to more permissive resident red pulp macrophages, which generate only sublethal oxidative bursts. Regional host expression of inducible nitric oxide synthase exposes some Salmonella to nitrosative stress, triggering effective local Salmonella detoxification through nitric oxide denitrosylase. Thus, reactive oxygen and nitrogen species influence dramatically different outcomes of disparate Salmonella-host cell encounters, which together determine overall disease progression.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk and Schürmann, Nura and Claudi, Beatrice and Zankl, Janine and Schmidt, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
ISSN:1931-3128
e-ISSN:1934-6069
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:27 Nov 2017 09:46
Deposited On:27 Mar 2014 13:13

Repository Staff Only: item control page