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Interleukin 7-induced lymphoid neogenesis in arthritis : recapitulation of a fetal developmental programme?

Finke, D. and Schmutz, S.. (2008) Interleukin 7-induced lymphoid neogenesis in arthritis : recapitulation of a fetal developmental programme? Swiss medical weekly, Vol. 138, H. 35-36. pp. 500-505.

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Official URL: http://edoc.unibas.ch/dok/A6007425

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Abstract

Chronic inflammatory diseases such as rheumatoid arthritis (RA) are associated with the de novo formation of organised lymphoid tissue in a subpopulation of patients. The aberrant expression of cytokines and chemokines by stromal cells plays an important role in recruitment and survival of effector cells of the immune system and the development of ectopic tertiary lymphoid organs (TLOs). TLOs may promote the persistence of inflammation and the recognition of self antigens. Recent studies in man and mice now indicate that interleukin 7 (IL-7) is implicated in the formation of TLOs and progression of chronic inflammation.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Children's Hospital > Developmental Immunology (Finke)
UniBasel Contributors:Finke, Daniela
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:EMH
ISSN:1424-7860
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:23 May 2014 08:34
Deposited On:23 May 2014 08:34

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