Kunz, J. and Hall, M. N.. (1993) Cyclosporin A, FK506 and rapamycin : more than just immunosuppression. Trends in Biochemical Sciences, 18 (9). pp. 334-348.
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Official URL: http://edoc.unibas.ch/dok/A5262074
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Abstract
The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophilin and FK506-FKBP complexes, and reveal a phosphatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall) |
|---|---|
| UniBasel Contributors: | Hall, Michael N. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0968-0004 |
| e-ISSN: | 0167-7640 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
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| Last Modified: | 09 Nov 2017 10:00 |
| Deposited On: | 22 Mar 2012 13:30 |
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