Collot, Jerome and Gradinaru, Julieta and Humbert, Nicolas and Skander, Myriem and Zocchi, Andrea and Ward, Thomas R.. (2003) Artificial metalloenzymes for enantioselective catalysis based on biotin-avidin. Journal of the American Chemical Society, 125 (30). pp. 9030-9031.
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Official URL: http://edoc.unibas.ch/dok/A5254438
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Abstract
Homogeneous and enzymatic catalysis offer complementary means to generate enantiomerically pure compounds. Incorporation of achiral biotinylated rhodium−diphosphine complexes into (strept)avidin yields artificial metalloenzymes for the hydrogenation of N-protected dehydroamino acids. A chemogenetic optimization procedure allows one to produce (R)-acetamidoalanine with 96% enantioselectivity. These hybrid catalysts display features reminiscent both of enzymatic and of homogeneous systems.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward) |
|---|---|
| UniBasel Contributors: | Ward, Thomas R. R. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Chemical Society |
| ISSN: | 0002-7863 |
| e-ISSN: | 1520-5126 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 24 Apr 2017 14:03 |
| Deposited On: | 22 Mar 2012 14:06 |
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