Type III secretion how Yersinia pestis infects its host

Mueller, Catherine A. and Broz, Petr and Cornelis, Guy R. and Müller, Shirley A. and Engel, Andreas. (2006) Type III secretion how Yersinia pestis infects its host. BIOforum Europe, Vol. 10, no. 4. pp. 40-42.

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Official URL: http://edoc.unibas.ch/dok/A5262471

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Type III secretion systems are used by many pathogenic bacteria to inject effector proteins into host cells. This secretion machinery, also called the injectisome, has the appearance of a mol. syringe. It is composed of an external needle, which is attached to the basal body spanning the bacterial membranes. Delivery of the effector proteins across the eukaryotic cell membrane requires, in addn., a set of three proteins called the translocators. These are exported by the injectisome itself. One of the most prominent species utilizing a type III secretion system is Yersinia pestis, the bacterium causing plague. Here we discuss the function of the injectisome, the involvement of LcrV (also known as V-antigen) in the translocation process, and its role as major protective antigen against plague. [on SciFinder (R)]
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Engel)
UniBasel Contributors:Müller, Shirley and Cornelis, Guy R. and Engel, Andreas H
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:GIT Verlag
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:26
Deposited On:22 Mar 2012 13:51

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