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Advanced polymer compartments: from catalytic nanocompartments to organelle mimics for biomedical applications

Korpidou, Maria. Advanced polymer compartments: from catalytic nanocompartments to organelle mimics for biomedical applications. 2024, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: https://edoc.unibas.ch/96726/

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Abstract

Polymersomes, vesicles enclosing an aqueous cavity and self-assembled by block copolymers are a powerful platform for creating various nano- and micro-devices, finding applications in therapeutic delivery and diagnostic systems, local and on-demand consumption or production of molecules by encapsulated enzymes and mimics of natural compartments. Highlighting the versatility of the block copolymers, this work presents how we can combine amphiphilic block copolymers with molecules and biomolecules to create advanced polymer nanocompartments for: 1. controlled drug delivery, 2. local inversion of a drug metabolite to its active form, 3. simultaneous generation of therapeutically relevant compounds for promoting drug synergism and 4. emulating naturally-occurring organelles in a bottom-up, photoreceptor mimic.
First, we engineered polymersomes for delivering drugs in a highly spatiotemporally controlled manner. A hydrophobic synthetic molecular rotary motor, activated by irradiation with low-power visible light w
Advisors:Palivan, Cornelia G
Committee Members:Huwyler, Jörg and Lecommandoux, Sébastien
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler)
UniBasel Contributors:Korpidou, Maria and Palivan, Cornelia G and Huwyler, Jörg
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:15505
Thesis status:Complete
Number of Pages:172
Language:English
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss155057
edoc DOI:
Last Modified:23 Oct 2024 04:30
Deposited On:22 Oct 2024 14:16

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