Dittrich, Tolga Daniel . Endovascular treatment of ischemic stroke due to large-vessel occlusion of the anterior circulation in the 6- to 24-hour time window. 2025, Doctoral Thesis, University of Basel, Faculty of Medicine.
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Official URL: https://edoc.unibas.ch/96707/
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Abstract
The starting point for this dissertation was the observation that in clinical practice some patients with anterior circulation large vessel occlusion (aLVO) receive endovascular treatment (EVT) even if they do not meet the guideline selection criteria in the 6-24 hour time window. This is due to the selective inclusion criteria of the DEFUSE-3 and DAWN trials. Although there have been some retrospective studies of less selected patient groups, these have left many relevant questions unanswered.
The aim of this dissertation was to help fill the research gaps regarding the efficacy and safety of EVT in less selected patient populations from clinical practice.
Based on the identified research gaps, the dissertation encompasses three projects. The first project evaluated the safety and efficacy of EVT compared with best medical treatment in patients with aLVO who did not meet the eligibility criteria of DEFUSE-3 and DAWN. In the second subproject, we aimed to investigate whether fulfillment of the DEFUSE-3 and DAWN inclusion criteria is a predictor of functional outcome at three months in patients who received EVT. In the third project, we investigated the association between different multimodal CT-based surrogate markers of early ischemic changes in patients presenting 6-24 hours after stroke onset and their predictive utility for functional outcomes at 90 days.
The aim of this dissertation was to help fill the research gaps regarding the efficacy and safety of EVT in less selected patient populations from clinical practice.
Based on the identified research gaps, the dissertation encompasses three projects. The first project evaluated the safety and efficacy of EVT compared with best medical treatment in patients with aLVO who did not meet the eligibility criteria of DEFUSE-3 and DAWN. In the second subproject, we aimed to investigate whether fulfillment of the DEFUSE-3 and DAWN inclusion criteria is a predictor of functional outcome at three months in patients who received EVT. In the third project, we investigated the association between different multimodal CT-based surrogate markers of early ischemic changes in patients presenting 6-24 hours after stroke onset and their predictive utility for functional outcomes at 90 days.
Advisors: | De Marchis, Gian Marco |
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Committee Members: | Kappos, Ludwig and Wiencierz, Andrea and Hill, Michael |
Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos) |
UniBasel Contributors: | Kappos, Ludwig |
Item Type: | Thesis |
Thesis Subtype: | Doctoral Thesis |
Thesis no: | 15619 |
Thesis status: | Complete |
Number of Pages: | 94 |
Language: | English |
Identification Number: |
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edoc DOI: | |
Last Modified: | 18 Jan 2025 05:30 |
Deposited On: | 17 Jan 2025 09:50 |
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