edoc

Liposomal formulations of Cyclosporin A : a biophysical approach to pharmacokinetics and pharmacodynamics

Fahr, A. and Seelig, J.. (2001) Liposomal formulations of Cyclosporin A : a biophysical approach to pharmacokinetics and pharmacodynamics. Critical Reviews in Therapeutic Drug Carrier Systems, 18 (2). pp. 141-172.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5257404

Downloads: Statistics Overview

Abstract

There are about 20 publications about liposomal formulations of Cyclosporin A (CyA) in the pharmaceutical and preclinical literature. Liposomal formulations were developed in order to reduce the nephrotoxicity of CyA and to increase pharmacological effects. However, conflicting results have been published as to the therapeutic properties of these formulations. This is also true for the change in pharmacokinetics and organ distribution of the liposomally encapsulated CyA as compared to conventionally formulated CyA. Using biophysical methods, it could be shown that CyA is not tightly entrapped in liposomal membranes, despite its high lipophilicity. CyA shows retardation only at high lipid concentrations in blood, following a massive injection of liposomes.This effect may diminish nephrotoxicity, as could be demonstrated by in vitro studies using a model tubule system. The results of these studies can be used to predict the formulation behavior in vivo and to optimize liposomal formulations. When applied in an early phase of the drug formulation process, these types of biophysical experiments can also help minimize animal experiments. However, these basic interaction studies cannot cover all physiological, pharmacological, and toxic effects in animals and humans.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig J)
UniBasel Contributors:Seelig, Joachim
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Belleg House
ISSN:0743-4863
e-ISSN:2162-660X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:14 Nov 2017 09:55
Deposited On:22 Mar 2012 13:50

Repository Staff Only: item control page