Imaging modes of atomic force microscopy for application in molecular and cell biology

Dufrêne, Yves F. and Ando, Toshio and Garcia, Ricardo and Alsteens, David and Martinez-Martin, David and Engel, Andreas and Gerber, Christoph and Müller, Daniel J.. (2017) Imaging modes of atomic force microscopy for application in molecular and cell biology. Nature Nanotechnology, 12 (4). pp. 295-307.

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Atomic force microscopy (AFM) is a powerful, multifunctional imaging platform that allows biological samples, from single molecules to living cells, to be visualized and manipulated. Soon after the instrument was invented, it was recognized that in order to maximize the opportunities of AFM imaging in biology, various technological developments would be required to address certain limitations of the method. This has led to the creation of a range of new imaging modes, which continue to push the capabilities of the technique today. Here, we review the basic principles, advantages and limitations of the most common AFM bioimaging modes, including the popular contact and dynamic modes, as well as recently developed modes such as multiparametric, molecular recognition, multifrequency and high-speed imaging. For each of these modes, we discuss recent experiments that highlight their unique capabilities.
Faculties and Departments:05 Faculty of Science > Departement Physik > Physik > Nanomechanik (Meyer)
UniBasel Contributors:Gerber, Christoph
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Nature Research
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:24 May 2023 08:28
Deposited On:24 May 2023 08:28

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