Hürlimann, E. and Hofmann, D. and Keiser, J.. (2023) Ivermectin and moxidectin against soil-transmitted helminth infections. Trends in parasitology, 39 (4). pp. 272-284.
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Official URL: https://edoc.unibas.ch/94534/
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Abstract
Ivermectin and moxidectin, two macrocyclic lactones, are potent antiparasitic drugs currently registered and mainly used against filarial diseases; however, their potential value for improved soil-transmitted helminth (STH) control has been acknowledged. This review provides insights on recent studies evaluating the efficacy of ivermectin and moxidectin as single or coadministered therapy against human soil-transmitted helminthiases (including Strongyloides stercoralis infections) and on pharmacokinetic/pharmacodynamic parameters measured in treated populations. Furthermore, we discuss current gaps for research, highlight advantages - but also existing challenges - for uptake of ivermectin and/or moxidectin treatment schemes into routine STH control in endemic countries.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Helminth Drug Development (Keiser) |
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| UniBasel Contributors: | Hürlimann, Eveline and Hofmann, Daniela and Keiser, Jennifer |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| ISSN: | 1471-4922 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 09 May 2023 06:30 |
| Deposited On: | 09 May 2023 06:30 |
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