Configuration-based electrical properties tomography

Purpose: To introduce phase-based conductivity mapping from a configuration space analysis.Methods: The frequency response function of balanced SSFP (bSSFP) is used to perform a configuration space analysis. It is shown that the transceive phase for conductivity mapping can be directly obtained by a simple fast Fourier transform of a series of phase-cycled bSSFP scans. For validation, transceive phase and off-resonance mapping with fast Fourier transform is compared with phase estimation using a recently proposed method, termed PLANET. Experiments were performed in phantoms and for in vivo brain imaging at 3 T using a quadrature head coil.Results: For fast Fourier transform, aliasing can lead to systematic phase errors. This bias, however, decreases rapidly with increasing sampling points. Interestingly, Monte Carlo simulations revealed a lower uncertainty for the transceive phase and the off-resonance using fast Fourier transform as compared with PLANET. Both methods, however, essentially retrieve the same phase information from a set of phase-cycled bSSFP scans. As a result, configuration-based conductivity mapping was successfully performed using eight phase-cycled bSSFP scans in the phantoms and for brain tissues. Overall, the retrieved values were in good agreement with ex-pectations. Conductivity estimation and mapping of the field inhomogeneities can therefore be performed in conjunction with the estimation of other quantitative pa-rameters, such as relaxation, using configuration theory.Conclusions: Phase-based conductivity mapping can be estimated directly from a simple Fourier analysis, such as in conjunction with relaxometry, using a series of phase-cycled bSSFP scans.