High-resolution simultaneous voltage and Ca2+ imaging

Vogt, Kaspar E. and Gerharz, Stephan and Graham, Jeremy and Canepari, Marco. (2010) High-resolution simultaneous voltage and Ca2+ imaging. The Journal of physiology, 589 (3). pp. 489-494.

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Official URL: https://edoc.unibas.ch/94096/

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Combining voltage and Ca2+ imaging allows the correlation of electrical and chemical activity at sub-cellular level. Here we describe a novel apparatus designed to obtain simultaneous voltage and Ca2+ measurements with single-trial resolution from sites as small as a few microns. These measurements can be obtained with negligible optical cross-talk between the two signals and negligible photo-damage of the preparation. The capability of the technique was assessed recording either from individual neurons in brain slices or from networks of cultured neurons. The present achievements open the gate to many novel physiological investigations requiring simultaneous measurement of voltage and Ca2+ signals.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Vogt)
UniBasel Contributors:Vogt, Kaspar and Gerharz, Stephan Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 Mar 2023 07:51
Deposited On:23 Mar 2023 07:51

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