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State of knowledge on the acquisition, diversity, interspecies attribution and spread of antimicrobial resistance between humans, animals and the environment: a systematic review

Meier, H. and Spinner, K. and Crump, L. and Kuenzli, E. and Schuepbach, G. and Zinsstag, J.. (2023) State of knowledge on the acquisition, diversity, interspecies attribution and spread of antimicrobial resistance between humans, animals and the environment: a systematic review. Antibiotics (Basel), 12. p. 73.

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Abstract

Resistance to antibiotics is considered one of the most urgent global public health concerns. It has considerable impacts on health and the economy, being responsible for the failure to treat infectious diseases, higher morbidity and mortality rates, and rising health costs. In spite of the joint research efforts between different humans, animals and the environment, the key directions and dynamics of the spread of antimicrobial resistance (AMR) still remain unclear. The aim of this systematic review is to examine the current knowledge of AMR acquisition, diversity and the interspecies spread of disease between humans, animals and the environment. Using a systematic literature review, based on a One Health approach, we examined articles investigating AMR bacteria acquisition, diversity, and the interspecies spread between humans, animals and the environment. Water was the environmental sector most often represented. Samples were derived from 51 defined animal species and/or their products A large majority of studies investigated clinical samples of the human population. A large variety of 15 different bacteria genera in three phyla (Proteobacteria, Firmicutes and Actinobacteria) were investigated. The majority of the publications compared the prevalence of pheno- and/or genotypic antibiotic resistance within the different compartments. There is evidence for a certain host or compartment specificity, regarding the occurrence of ARGs/AMR bacteria. This could indicate the rather limited AMR spread between different compartments. Altogether, there remains a very fragmented and incomplete understanding of AMR acquisition, diversity, and the interspecies spread between humans, animals and the environment. Stringent One Health epidemiological study designs are necessary for elucidating the principal routes and dynamics of the spread of AMR bacteria between humans, animals and the environment. This knowledge is an important prerequisite to develop effective public health measures to tackle the alarming AMR situation.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Directorate (DIR) > Medical Services (Künzli/Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Human and Animal Health > One Health (Zinsstag)
UniBasel Contributors:Meier, Hélène and Crump, Lisa and Künzli, Esther and Zinsstag, Jakob Z
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2079-6382 (Print)2079-6382 (Electronic)2079-6382 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:13 Feb 2023 09:02
Deposited On:13 Feb 2023 09:02

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