Genetic slippage after sex maintains diversity for parasite resistance in a natural host population

Ameline, Camille and Voegtli, Felix and Andras, Jason and Dexter, Eric and Engelstädter, Jan and Ebert, Dieter. (2022) Genetic slippage after sex maintains diversity for parasite resistance in a natural host population. Science Advances, 8 (46). eabn0051.

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Official URL: https://edoc.unibas.ch/93112/

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Although parasite-mediated selection is a major driver of host evolution, its influence on genetic variation for parasite resistance is not yet well understood. We monitored resistance in a large population of the planktonic crustacean; Daphnia magna; over 8 years, as it underwent yearly epidemics of the bacterial pathogen; Pasteuria ramosa; . We observed cyclic dynamics of resistance: Resistance increased throughout the epidemics, but susceptibility was restored each spring when hosts hatched from sexual resting stages. Host resting stages collected across the year showed that largely resistant host populations can produce susceptible sexual offspring. A genetic model of resistance developed for this host-parasite system, based on multiple loci and strong epistasis, is in partial agreement with our findings. Our results reveal that, despite strong selection for resistance in a natural host population, genetic slippage after sexual reproduction can be a strong factor for the maintenance of genetic diversity of host resistance.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Integrative Biologie > Evolutionary Biology (Ebert)
UniBasel Contributors:Ebert, Dieter and Ameline, Camille and Dexter, Eric
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:02 Feb 2023 14:43
Deposited On:02 Feb 2023 14:43

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