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Cannabis use and cannabis use disorders and their relationship to mental disorders : a 10-year prospective-longitudinal community study in adolescents

Wittchen, Hans-Ulrich and Froehlich, Christine and Behrendt, Silke and Guenther, Agnes and Rehm, Juergen and Zimmermann, Petra and Lieb, Roselind and Perkonigg, Axel. (2007) Cannabis use and cannabis use disorders and their relationship to mental disorders : a 10-year prospective-longitudinal community study in adolescents. Drug and alcohol dependence, Vol. 88, Suppl. 1 , S60-S70.

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Official URL: http://edoc.unibas.ch/dok/A5248982

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Abstract

Background: Whereas the role of externalizing disorders is relatively well established in predicting the onset of cannabis use (CU) or cannabis use disorder (CUD), the status of anxiety and mood disorders in predicting CU and CUD remains controversial. Objective: (1) To examine cross-sectional and prospective associations of CU and CUD with a range of mental disorders and whether anxiety and mood disorders are associated with CU/CUD after adjusting for externalizing disorders. Methods: N = 1395 community subjects aged 14-17 at baseline were followed-up at three waves prospectively over 10 years. Substance use, substance disorders and mental disorders were assessed using the DSM-IV/M-CIDI. Results: (1) The baseline prevalence rates where 19.3 and 2.6 CU and 13.7 other substance use disorders, mood and anxiety disorders were associated with CU and CUD. (3) Associations of panic-anxiety with CU and of depressive and bipolar disorders with CU and CUD were significant after controlling for externalizing disorders. Conclusion: A range of psychopathological conditions, including depressive, bipolar and less consistently anxiety disorders as well as the degree of their comorbidity are significantly associated with incident CU and progression to CUD, even when controlling for externalising disorders. A better understanding of this complex interplay may result in better aetiological models and intervention strategies. (c) 2007 Published by Elsevier Ireland Ltd.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Lieb, Roselind
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0376-8716
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:25
Deposited On:22 Mar 2012 13:48

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