Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm: methodology and applications

Martin, H. and Falconer, J. and Addo-Yobo, E. and Aneja, S. and Arroyo, L. M. and Asghar, R. and Awasthi, S. and Banajeh, S. and Bari, A. and Basnet, S. and Bavdekar, A. and Bhandari, N. and Bhatnagar, S. and Bhutta, Z. A. and Brooks, A. and Chadha, M. and Chisaka, N. and Chou, M. and Clara, A. W. and Colbourn, T. and Cutland, C. and D'Acremont, V. and Echavarria, M. and Gentile, A. and Gessner, B. and Gregory, C. J. and Hazir, T. and Hibberd, P. L. and Hirve, S. and Hooli, S. and Iqbal, I. and Jeena, P. and Kartasasmita, C. B. and King, C. and Libster, R. and Lodha, R. and Lozano, J. M. and Lucero, M. and Lufesi, N. and MacLeod, W. B. and Madhi, S. A. and Mathew, J. L. and Maulen-Radovan, I. and McCollum, E. D. and Mino, G. and Mwansambo, C. and Neuman, M. I. and Nguyen, N. T. V. and Nunes, M. C. and Nymadawa, P. and O'Grady, K. F. and Pape, J. W. and Paranhos-Baccala, G. and Patel, A. and Picot, V. S. and Rakoto-Andrianarivelo, M. and Rasmussen, Z. and Rouzier, V. and Russomando, G. and Ruvinsky, R. O. and Sadruddin, S. and Saha, S. K. and Santosham, M. and Singhi, S. and Soofi, S. and Strand, T. A. and Sylla, M. and Thamthitiwat, S. and Thea, D. M. and Turner, C. and Vanhems, P. and Wadhwa, N. and Wang, J. and Zaman, S. M. and Campbell, H. and Nair, H. and Qazi, S. A. and Nisar, Y. B. and World Health Organization Pneumonia Research Partnership to Asse, . (2022) Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm: methodology and applications. J Glob Health, 12. 04075.

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BACKGROUND: The existing World Health Organization (WHO) pneumonia case management guidelines rely on clinical symptoms and signs for identifying, classifying, and treating pneumonia in children up to 5 years old. We aimed to collate an individual patient-level data set from large, high-quality pre-existing studies on pneumonia in children to identify a set of signs and symptoms with greater validity in the diagnosis, prognosis, and possible treatment of childhood pneumonia for the improvement of current pneumonia case management guidelines. METHODS: Using data from a published systematic review and expert knowledge, we identified studies meeting our eligibility criteria and invited investigators to share individual-level patient data. We collected data on demographic information, general medical history, and current illness episode, including history, clinical presentation, chest radiograph findings when available, treatment, and outcome. Data were gathered separately from hospital-based and community-based cases. We performed a narrative synthesis to describe the final data set. RESULTS: Forty-one separate data sets were included in the Pneumonia Research Partnership to Assess WHO Recommendations (PREPARE) database, 26 of which were hospital-based and 15 were community-based. The PREPARE database includes 285 839 children with pneumonia (244 323 in the hospital and 41 516 in the community), with detailed descriptions of clinical presentation, clinical progression, and outcome. Of 9185 pneumonia-related deaths, 6836 (74%) occurred in children <1 year of age and 1317 (14%) in children aged 1-2 years. Of the 285 839 episodes, 280 998 occurred in children 0-59 months old, of which 129 584 (46%) were 2-11 months of age and 152 730 (54%) were males. CONCLUSIONS: This data set could identify an improved specific, sensitive set of criteria for diagnosing clinical pneumonia and help identify sick children in need of referral to a higher level of care or a change of therapy. Field studies could be designed based on insights from PREPARE analyses to validate a potential revised pneumonia algorithm. The PREPARE methodology can also act as a model for disease database assembly.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Clinical Research (Reither)
UniBasel Contributors:D'Acremont, Valérie
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2047-2986 (Electronic)2047-2978 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Jan 2023 08:40
Deposited On:06 Jan 2023 08:40

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