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Building sustainable clinical trial sites in Sub-Saharan Africa through networking, infrastructure improvement, training and conducting clinical studies: the PanACEA approach

Mekota, AM. and Gillespie, SH. and Hoelscher, M. and Diacon, AH. and Dawson, R. and Churchyard, G. and Sanne, I. and Minja, L. and Kibiki, G. and Maboko, L. and Lakhi, S. and Joloba, M. and Alabi, A. and Kirenga, B. and McHugh, TD. and Grobusch, MP. and Boeree, MJ. and PanAcea consortium, . (2022) Building sustainable clinical trial sites in Sub-Saharan Africa through networking, infrastructure improvement, training and conducting clinical studies: the PanACEA approach. Acta Trop, 238. p. 106776.

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Official URL: https://edoc.unibas.ch/92201/

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Abstract

INTRODUCTION: The Pan-African Consortium for the Evaluation of Anti-Tuberculosis Antibiotics (PanACEA) was designed to build tuberculosis (TB) trial capacity whilst conducting clinical trials on novel and existing agents to shorten and simplify TB treatment. PanACEA has now established a dynamic network of 11 sub-Saharan clinical trial sites and four European research institutions. OBJECTIVES: In 2011, a capacity development program, funded by the European & Developing Countries Clinical Trials Partnership (EDCTP), was launched with four objectives, aiming at strengthening collaborating TB research sites to reach the ultimate goal of becoming self-sustainable institutions: networking; training; conducting clinical trials; and infrastructure scaling-up of sites. METHODS: Assessment in six sub-Saharan TB-endemic countries (Gabon, Kenya, South Africa, Tanzania, Uganda and Zambia) were performed through a structured questionnaire, site visits, discussion with the PanACEA consortium, setting of milestones and identification of priorities and followed-up with evaluations of each site. The results of this needs-based assessment was then translated into capacity development measures. RESULTS: In the initial phase, over a 4-year period (March 2011 - June 2014), the programme scaled-up six sites; conducted a monitoring training program for 11 participants; funded five MSc and four PhD students, fostering gender balance; conducted four epidemiological studies; supported sites to conduct five Phase II studies and formed a sustainable platform for TB research (panacea-tb.net). CONCLUSION: Our experience of conducting TB clinical trials within the PanACEA programme environment of mentoring, networking and training has provided a sound platform for establishing future sustainable research centres. Our goal of facilitating emergent clinical TB trial sites to better initiate and lead research activities has been mostly successful.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Clinical Research (Reither)
UniBasel Contributors:Minja, Lilian Tina
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1873-6254 (Electronic)0001-706X (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:06 Jan 2023 07:59
Deposited On:06 Jan 2023 07:59

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