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The burden of surgical site infections and related antibiotic resistance in two geographic regions of Sierra Leone: a prospective study

Lakoh, S. and Yi, L. and Russell, J. B. W. and Zhang, J. and Sevalie, S. and Zhao, Y. and Kanu, J. S. and Liu, P. and Conteh, S. K. and Williams, C. E. E. and Barrie, U. and Sheku, M. G. and Jalloh, M. B. and Adekanmbi, O. and Jiba, D. F. and Kamara, M. N. and Deen, G. F. and Okeibunor, J. C. and Yendewa, G. A. and Guo, X. and Firima, E.. (2022) The burden of surgical site infections and related antibiotic resistance in two geographic regions of Sierra Leone: a prospective study. Ther Adv Infect Dis, 9. p. 20499361221135128.

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Abstract

Despite the prolongation of hospitalization, increase in morbidity, mortality and cost of care associated with both surgical site infections (SSIs) and antibiotic resistance, there are limited data on SSIs and antibiotic resistance to guide prevention strategies in Sierra Leone. This study assessed the burden of SSIs and related antibiotic resistance in the 34 Military Hospital (MH) and Makeni Government Hospital (MGH) located in two geographic regions of Sierra Leone using a prospective study design to collect data from adults aged 18 years or older. Of the 417 patients, 233 (55.9%) were enrolled in MGH. Most were women 294 (70.5%). The incidence rate of SSI was 5.5 per 1000 patient-days, and the cumulative incidence of SSI was 8.2%. Common bacteria isolated in MH were Escherichia coli (6,33.3%) and Pseudomonas aeruginosa (3,16.7%) and in MGH were P. aeruginosa (3,42.9%) and Proteus mirabilis (2,28.9%). Of the gram-negative bacteria, 40% were Extended-spectrum beta-lactamase-producing Enterobacteriaceae, 33% were Carbapenem-resistant P. aeruginosa and 10% were carbapenem-resistant Enterobacteriaceae. Although the incidence of SSIs in our study is lower than previously reported, the rate of antibiotic resistance reported in this study is high. Urgent action is needed to invest in the microbiology infrastructure to support SSI surveillance and prevention strategies.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Clinical Research (Reither)
UniBasel Contributors:Firima, Emmanuel
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2049-9361 (Print)2049-937X (Electronic)2049-9361 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:06 Jan 2023 08:06
Deposited On:06 Jan 2023 08:06

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