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Ambient ionization source based on a dielectric barrier discharge for direct testing of pharmaceuticals using ion mobility spectrometry

Chantipmanee, Nattapong and Furter, Jasmine S. and Hauser, Peter C.. (2022) Ambient ionization source based on a dielectric barrier discharge for direct testing of pharmaceuticals using ion mobility spectrometry. Analytica Chimica Acta, 1195. p. 339432.

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Abstract

The instrument is based on a miniature plasma source mounted at an oblique angle close to the injection gate of the ion mobility spectrometer. The plasma torch consists of two 5 mm wide external cylindrical electrodes, 10 mm apart, which are placed coaxially around a fused silica tube (1.5 mm i.d. and 3.0 mm o.d.). A small helium plasma is created by applying a alternating voltage of 8 kV at 28 kHz and employed for the direct desorption and ionization of solid or liquid samples, which are placed on an electrically isolated support. The separation section of the ion mobility spectrometer has a drift tube of 10 cm length and an applied high voltage of 4 kV. The instrument was built in-house at low cost and can easily be duplicated. Its usefulness was demonstrated by the rapid identification of five different pharmaceutical drugs, namely acetaminophen, loratadine, norfloxacin, tadalafil, thiamine as well as caffeine in ground coffee beans.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Analytische Chemie (Hauser)
UniBasel Contributors:Hauser, Peter C.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0003-2670
e-ISSN:1873-4324
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
edoc DOI:
Last Modified:11 Jan 2023 09:16
Deposited On:11 Jan 2023 09:16

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