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Functional network topography of the medial entorhinal cortex

Obenhaus, Horst A. and Zong, Weijian and Jacobsen, R. Irene and Rose, Tobias and Donato, Flavio and Chen, Liangyi and Cheng, Heping and Bonhoeffer, Tobias and Moser, May-Britt and Moser, Edvard I.. (2022) Functional network topography of the medial entorhinal cortex. Proceedings of the National Academy of Sciences of the United States of America, 119 (7). e2121655119.

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Abstract

The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical and activity data across large populations of neurons during unrestrained behavior, which neither electrophysiological nor previous imaging methods fully afford. Here, we examined the topographic arrangement of spatially modulated neurons in the superficial layers of MEC and adjacent parasubiculum using miniaturized, portable two-photon microscopes, which allow mice to roam freely in open fields. Grid cells exhibited low levels of co-occurrence with OV cells and clustered anatomically, while border, HD, and OV cells tended to intermingle. These data suggest that grid cell networks might be largely distinct from those of border, HD, and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Neurobiology (Donato)
UniBasel Contributors:Donato, Flavio
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Academy of Sciences
ISSN:0027-8424
e-ISSN:1091-6490
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:10 Jan 2023 08:11
Deposited On:10 Jan 2023 08:11

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