Tailoring Polymer-Based Nanoassemblies for Stimuli-Responsive Theranostic Applications

Muthwill, Moritz S. and Kong, Phally and Dinu, Ionel Adrian and Necula, Danut and John, Christoph and Palivan, Cornelia G.. (2022) Tailoring Polymer-Based Nanoassemblies for Stimuli-Responsive Theranostic Applications. Macromolecular Bioscience, 22 (11). p. 2200270.

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Official URL: https://edoc.unibas.ch/91529/

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Polymer assemblies on the nanoscale represent a powerful toolbox for the design of theranostic systems when combined with both therapeutic compounds and diagnostic reporting ones. Here, recent advances in the design of theranostic systems for various diseases, containing-in their architecture-either polymers or polymer assemblies as one of the building blocks are presented. This review encompasses the general principles of polymer self-assembly, from the production of adequate copolymers up to supramolecular assemblies with theranostic functionality. Such polymer nanoassemblies can be further tailored through the incorporation of inorganic nanoparticles to endow them with multifunctional therapeutic and/or diagnostic features. Systems that change their architecture or properties in the presence of stimuli are selected, as responsivity to changes in the environment is a key factor for enhancing efficiency. Such theranostic systems are based on the intrinsic properties of copolymers or one of the other components. In addition, systems with a more complex architecture, such as multicompartments, are presented. Selected systems indicate the advantages of such theranostic approaches and provide a basis for further developments in the field.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Palivan, Cornelia G and Muthwill, Moritz and Kong, Phally and Necula, Danut and Dinu, Ionel Adrian and John, Christoph Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:15 Dec 2022 09:22
Deposited On:15 Dec 2022 09:22

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