Overview: mycolactone, the macrolide toxin of Mycobacterium ulcerans

Röltgen, K. and Pluschke, G.. (2022) Overview: mycolactone, the macrolide toxin of Mycobacterium ulcerans. In: Mycobacterium ulcerans. Methods and protocols, 2387. New York, NY, pp. 105-108.

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The acquisition by a Mycobacterium marinum-like progenitor of a plasmid encoding enzymes for the biosynthesis of the highly potent macrolide toxin mycolactone has set off the evolution of M. ulcerans toward a new mycobacterial species. While the selective advantage of producing mycolactone for survival in environmental niche(s) of the pathogen is unclear, there is no doubt that the cytotoxic, immunomodulatory, and analgesic properties of mycolactone are key for the establishment and progression of M. ulcerans infections in the host. Improved procedures for the isolation, handling, and detection of the amphiphilic and light-sensitive toxin have facilitated studies to unravel molecular mechanisms of mycolactone action on host cells in vitro and on cellular and immune responses in animal models. The pivotal role of mycolactone in the pathology of Buruli ulcer and the fact that the toxin has not been associated with other pathogens make it an ideal target for therapeutics/vaccines aiming at mycolactone neutralization and for the development of assays for the diagnosis of the disease.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Molecular Immunology (Pluschke)
UniBasel Contributors:Pluschke, Gerd
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
ISSN:1940-6029 (Electronic)1064-3745 (Linking)
Note:Publication type according to Uni Basel Research Database: Book item
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Last Modified:27 Dec 2022 16:51
Deposited On:27 Dec 2022 16:51

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