Tehran environmental and neurodevelopmental disorders (TEND) cohort study: phase I, feasibility assessment

Shamsipour, M. and Pirjani, R. and Zare Jeddi, M. and Effatpanah, M. and Rastkari, N. and Kashani, H. and Shirazi, M. and Hassanvand, M. S. and Künzli, N. and Shariat, M. and Sadat Javadi, F. and Shariatpanahi, G. and Hassanpour, G. and Peykarporsan, Z. and Jamal, A. and Ardestani, M. E. and $Hoseini, F. S. and Dalili, H. and Nayeri, F. S. and Mesdaghinia, A. and Naddafi, K. and Shahtaheri, S. J. and Nasseri, S. and Yunesian, F. and Rezaeizadeh, G. and Amini, H. and Yokoyama, K. and Vigeh, M. and Yunesian, M.. (2020) Tehran environmental and neurodevelopmental disorders (TEND) cohort study: phase I, feasibility assessment. J Environ Health Sci Engineer, 18. pp. 733-742.

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Official URL: https://edoc.unibas.ch/91229/

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Purpose To advance knowledge about childhood neurodevelopmental disorders and study their environmental determinants, we conducted a study in Tehran, Iran to assess the feasibility of prospective birth cohort study. Methods We evaluated participation of pregnant women, feasibility of sampling biological material, and health care services availability in Tehran in four steps: (1) first trimester of pregnancy; (2) third trimester of pregnancy; (3) at delivery; and (4) two to three months after delivery. We collected related data through questionnaires, also various biological samples were obtained from mothers (blood, urine, milk and nails-hands and feet) and newborns (umbilical cord blood, meconium, and urine samples) from February 2016 to October 2017. Results overall 838 eligible pregnant women were approached. The participation rate was 206(25%) in our study and about 185(90%) of subjects were recruited in hospitals. Out of 206 participants in the first trimester, blood, urine, hand nail, and foot nail samples were collected from 206(100%),193(93%), 205(99%), and 205(99%), respectively. These values dropped to 65(54%), 83(69%), 84(70%), and 84(70%) for the remaining participants 120(58%) in the third trimester, respectively. Also, we gathered milk samples from 125(60%) of mothers at two to three months after delivery. Conclusion Our findings suggest that hospitals were better places for recruitment of subjects in a birth cohort in Tehran. We further concluded that birth cohort study recruitment can be improved by choosing appropriate gestational ages. Obtaining the newborn's urine, meconium, and umbilical cord blood were challenging procedures and require good collaboration between hospital staff and researchers.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Air Pollution and Health (Künzli)
UniBasel Contributors:Künzli, Nino
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Dec 2022 09:57
Deposited On:29 Dec 2022 09:57

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